Treatment of chlamydia should be carried out under the control of the infectious examist. The duration of such therapy is determined individually, but on average is 10-12 days. Mandatory condition is the use of antibiotic drugs. However, not all of them are equally effective in this case.

Amoxiclav is a wide spectrum antibiotic. Its main active substance - obtained by the semi-synthetic path of Penicillin (amoxicillin), as well as clavulanic acid, which is the direct inhibitor of β-lactamas. Since most intracellular infections are resistant to penicillin - amoxiclaw in chlamydia are not prescribed. In addition, clavulanic acid itself has a very weak activity against urogenital infections.

Amoxiclav acts only on a narrow circle of gram-negative and gram-positive bacteria. As well as on some types of aerobic and anaerobic microorganisms. All metieticillin resistant strains of infections are fully resistant to the effects of this antibiotic.

According to its pharmacokinetic properties, the drug is similar to other representatives of the penicillin group. The combination of these drugs cannot affect the efficiency of using amoxiclava during chlamydia.

The maximum concentration of the active substance in the blood plasma is reached 3-4 hours after injection. Both components are well absorbed by the tissues and fluids of the body, the largest concentrations of penicillin accumulate in the lungs, the uterus and ovaries, as well as in the pleural and synovial fluid. Amoxiclav is not capable of penetrating the hemato cephalic barrier, which means it does not accumulate in the brain shells, in the absence of inflammatory processes.

Chlamydia's aircraft with this drug is not permissible, especially for nursing women. Amoxicillin is poorly associated with blood proteins, so in this case its concentration in breast milk will be very high. Also, amoxiclave is dangerous for people who suffer from functional diseases of the kidneys and liver, since it is excreted from the body in virtually unchanged by the glomerular filtration.

Amoxiclav in chlamydia can be assigned to the patient only in one case, if against the background of infection, streptococcal bacteria occurred. Then amoxicillin can be used as an integral part of the dosage scheme, with the exception of therapy with aminoglycosidal antibiotics.

The World Health Organization assesses the annual morbidity in the world in 100 million. Prevalence of variable in different countries: in decadent developing ten times higher. Russia registers more than 100 cases per 100 thousand population annually, which is 20% of all detected venereal infections.

Clamydia is classified as bacteria, they contain DNA and RNA. These microorganisms are capable of persistent in the host cells, and fully depend on its energy resources. Universal 2 phase life cycle allows pathogens to adapt to intracellular and extracellular form of existence.

Incubation period - from 7 to 21 days.

Symptoms, as a rule, is localized in the infected zone, but there is a possibility of propagation of infection.

Antibiotics in Trichomoniase: Men and Women's Treatment Schemes

CDC (Center for the Control and Prevention of Diseases of the United States) recommends azithromycin and doxycycline as presidency drugs for the treatment of chlamydial infection, efficiency - 95%.

There are confirmed data that azithromycin causes a failure heart RhythmWhat you need to pay attention to. For patients with QT-interval anomalies or receiving preparations for arrhythmia, it is preferable to use doxycycline.

For several decades, doxycycline 0.1 g 2 rd / d was used to treat chlamydiasis. orally, a course of 7 days.

note

Studies have shown that azithromycin adopted at a dose of 1 mg once is more effective than the weekly reception of doxycycline.

Rifampicin which is highly active in relation to Chlamydia Trachushatis, and has a long half-life, is sometimes used as a single dose for the treatment of chlamydial urethritis of non-nodococcal etiology. Currently, it can be recommended for receiving women with uncomplicated genital infection.

After therapy performed, the recording on chlamydia is not required, but recommended after 3 months to exclude reinfection tests.

- the drug of choice, as active against several venereal infections at the same time:

• chlamydia trachomatis;
• etc.

200 mg 2 r. / D. Within 7 days, Levofloxacin 500 mg once a day, within 7 days, considered as alternative treatment options.

With chlamydia, complicated by the inflammatory process in the pelvic organs, prescribe cephalosporins together with 2 weeks of doxycycline, or apply the scheme:

Clindamycin plus gentamicin; Ampicillin-Sulbactam plus doxycycline.

Abulator treatment is based on the following schemes:

The second or third generation cephalosporins in the initial one-time dose in combination with doxycycline for 14 days, with or without metronidazole 500 mg twice a day, a course of 14 days.

Due to the appearance of the stability of the sloster gocokkov to fluoroquinolones, the latter are not recommended.

Chlamydia and are usually treated for 14 days.

• Azitromycin 1 g is single, or doxycycline 100 mg orally twice a day for 7 days.
• alternative scheme: Tetracycline 500 mg inside 4 times a day for 7 days, or erythromycin 500 mg inside twice a day for 7 days, or offloxacin 200-400 mg orally twice a day, within 7 days

For the treatment of anorectal chlamydial infection, WHO recommends doxycycline 100 mg orally twice a day, for 7 days or azithromycin 1 g inwards once.

note

Randomized studies have shown that parenteral and oral schemes have similar clinical efficacy at moderate manifestations.

Treatment of chlamydia in pregnant women

• Azithromycin 1 g once;
• Josamamicin 500-1000 mg 2 r. / D. - 7 days;
• Amoxicillin 500 mg 4 r. / D. - 7 days.

note

• Azithromycin 1 g inside once;
• Amoxicillin 500 mg inside 3 times a day for 7 days;
• Erythromycin 500 mg inside twice a day for 7 days.

The most common venereal infection caused by the smallest microorganisms - chlamydia, is difficult to treat. In the overwhelming majority of cases, its subsequently, patients fall into the doctor's field of view, already having launched shape Diseases. The consequences of chlamydia are impressive. These are not only inflammatory processes of urinary organs and, as a result, violation reproductive function In both sexes, and serious eye diseases, joints, lymph nodes. Chlamydia antibiotics are prescribed to destroy the pathogen and eliminate the inflammatory process, as well as preventing hazardous complications. They must be taken in strict accordance with medical recommendations. The choice of the drug depends on the form and stage of the disease.

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Indications for the use of antibiotics during chlamydia

Infectious inflammatory diseases of the urinary organs: non-phonococcal urethritis in persons of both sexes; Cervicitis, Salpingitis, endometritis - in women, prostatitis and orchoepididimitis - in men, combined damage to urinary organs, eyes and joints (Reiter syndrome).

Antibiotics are appointed to persons with positive results of laboratory research for chlamydia, their sexual partners, newborns from mothers with chlamydia.

Pharmacodynamics

Chlamydia is intracellular microorganisms, so all drugs appointed for their eradication have the ability to penetrate the cells.

Semi-synthetic macrolid Azithromycin It is a preferred preparation in the treatment of chlamydia. This is explained by several reasons, firstly, the opportunity to cure an infection with a single reception (it is easy to comply with all the rules), secondly, it is active to many combined infectious agents, in particular, ureaplasm and gonococcal, although it is not a preparation of the first line in the treatment of gonorrhea . It has a bacteriostatic action in therapeutic doses, like all representatives of this group, penetrating through the cell wall and binding to the fragmentary portion of the bacterium ribosome, prevents the normal synthesis of its protein, braking the transfer of peptides from the acceptor site to donor. In addition to the bacteriostatic, antibiotics of this group have the ability to somewhat stimulate immunity and suppress the activity of pro-inflammatory mediators.

Erythromycin- the first antibiotic of this class is considered the most non-toxic natural origin. It is considered alternative, it is used in the treatment of pregnant women, adolescents and newborns. The spectrum of action is similar to the previous one, however, many microorganisms have already acquired resistance to this drug and its effectiveness is considered lower than in later macrolides.

Josamamicin, The representative of the same class of antibiotics, has a natural origin and higher activity than two previous ones. In contrast to others, it practically does not oppress the useful microflora of the gastrointestinal tract. His resistance is developing less frequently than other representatives of this group.

From macrolides in the treatment of chlamydia as alternative drugs can also be used Clarithromycin and Roxitromycin.

Tetracyclined antibiotic Doxycycline It is also prescribed quite often with chlamydia. Since the drugs of this series in many pathogens have already developed sustainability, it is recommended to apply in primary patients with an uncomplicated disease. It has a pharmacological effect, the coal production of proteins in the cells of bacteria, intervening in the transmission process of its genetic code. It has a wide range of activity, in particular, to chlamydia and gonokoks. Its disadvantage is also the widespread stability of pathogens to the antibiotics of the tetracycline row.

Fluorinated quinolones are considered reserve preparations and are applied in cases where the previous ones are not effective. Bactericidal action shows - inhibit the enzymatic activity of two microbial topoisomeras of the second type, which are necessary for the vital activity of bacteria - the process of implementing their genetic information (DNA biosynthesis). For the eradication of chlamydia, the second generation preparations can be appointed Norfloxacin, Offloxacin or Ciprofloxacin, Manifesting antihionococcal activity. Ureaplasm, in most cases, insensitive to these drugs. If the mixture infection includes this pathogen, then apply Levofloxacin or Sparfloxacin, Belonging to the third generation of this group of antibiotics.

Pharmacokinetics

Azithromycin It is absorbed from the gastrointestinal channel at a good rate, since this drug is characterized by acid resistant and affinity for fat. The greatest plasma concentration is determined after the time expires from 2.5 to three hours. About 37% of the introduced dose fall into the bloodstream. Well distributed in all tissues. For all antibiotics of this group, high tissue, not plasma concentration, which is due to low affinity for proteins, as well as the ability to penetrate the cells of pathogenic microorganisms and accumulate in lysosomes. Azithromycin is transported to the foci of infection by phagocyt cells, where its release occurs during their activities. The higher concentration of the drug in infected tissues is determined compared to healthy, comparable to the degree of inflammatory edema. The function of phagocyte cells is not violated. Therapeutic concentration of the drug is maintained in places of localization of the inflammatory process for five to seven days from the moment of its last reception. It is this ability that allows the azithromycin once or short courses. Elimination from serum is long and two-stage than and the appointment is explained once a day.

Absorption speed Erythromycin The digestive channel is determined by the characteristics of the patient's body. The greatest plasma concentration is registered two hours from the reception of the drug, binds to plasma albumin from 70 to 90% of the adopted dose. The distribution occurs mainly in the tissues and body fluids, is able to be absorbed by 30-65%. Malotoxic, overcomes the placental barrier and is determined in breast milk.

Splits in the liver, metabolic products are removed almost completely with bile, a minor part - unchanged through the urinary paths. Normally working kidneys ensure the elimination of half the adopted dose of erythromycin already two hours after the reception.

Josamamicin Almost completely with good speed is absorbed from digestive tract. Unlike other macrolides, its bioavailability does not depend on food intake. The greatest serum concentration is determined by an hour after an hour, the plasma albumin binds about 15% of the accepted active substance. It is well distributed in the tissues, overcomes the placenta and is determined in breast milk. Split in the liver. Metabolites slowly leave the body through biliary paths, less than 15% through urinary organs.

Doxycycline It is absorbed quickly, regardless of the presence of food in the gastrointestinal tract, and its elimination occurs slowly. Therapeutic concentration in serum is determined for 18 or more hours after taking, the bond with plasma albumin is approximately 90%. The active ingredient is quickly distributed in liquid substances and tissues of the body. Elimination occurs through the gastrointestinal tract (about 60%), with urine - the rest. The half-life is from 12 hours before the day.

Fluorinated quinolones Well, quickly and universally distributed in the tissues and organs of various systems, creating significant concentrations of the active substance. In addition to Norfloxacin, the most concentrated in the intestines, urinary tracts and prostate gland, where infection in male patients is more often local.

The greatest level of tissue saturation of various localizations is observed in therapy with offloxacin, levofloxacin, couploxacin, sparfloxacin.

Possess medium among antibiotics the ability to penetrate through cell shells Inside the cell.

The rate of biotransformation and elimination depends on the physicochemical properties of the active substance. In general, for drugs of this group is characterized by rapid suction and distribution. Beefloxacin, the least - offloxacin, levofloxacin, whose bioavailability is almost 100%, is most actively metabolized. The biological accessibility of ciprofloxacin is also high, at the level of 70-80%.

The fluctuations of the elimination period of half of the adopted dose in fluorinated quinolones constitute a wide time range from three to four hours at Norfloxacin to 18-20 hours at Sparfloxacin. Most are excreted through urinary organs, and from three to 28% (depending on the drug) - intestine.

The renal dysfunction in the patient lengthens the semi-exploration interval in all drugs of this group, especially from offloxacin and levofloxacin. In cases of serious disorders, the kidney function is required to adjust the dose of any fluorinated quinolone.

Antibiotics in chlamydia in men are prescribed individually depending on the shape and stage of the disease, the localization of infection, the availability of complications and combined infections. When choosing a drug, the patient's portability of a certain group of antibacterial agents is also taken into account, the need to combine them with the reception of any other drugs in the presence of a patient chronic diseases, Sensitivity of infectious agents to certain drugs.

The same principles are guided by doctors when they choose antibiotics during chlamydia in women. Special category of patients are future mother.

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Use of antibiotics during chlamydia during pregnancy

Doxycycline and antibiotics belonging to the group of fluoroquinolones, women who carry a child are not prescribed.

Antibiotic tetracycline group Doxycycline can provoke anomalies of formation bone tissue Fetal.

Fluoroquinolones refer to toxic antibiotics, however, there are no reliable data on the teratogenicity of these drugs. There are no less, in research on laboratory animals, their offspring developed arthropathies, besides, there are reports of single cases of hydrocephalius, intracranial hypertension in newborns, whose mothers took the drugs of this group during tooling.

Macrolred antibiotics are penetrated through a placental barrier, but are considered not teratogenic and low-toxic. Therefore, the drug for the treatment of chlamydia in pregnant women is chosen from this group. The safest erythromycin, however, Viliprafen (Josamamicine) and Spiramyzin are considered more efficient to be more effective. Azithromycin prescribed only by life indications. The effect of other drugs of this group on the fruit has been studied little, so they are not recommended to apply for the treatment of pregnant women. Clarithromycin, according to some data, can have a negative impact.

Contraindications

A common allergic response to the drug is common to all antibiotics.

Fluoroquinolones and doxycycline are contraindicated by pregnant and nursing women.

Doxycycline is not appointed to children from birth to full seven years, as well as patients with severe liver pathologies.

Fluorinated quinolones are not used in pediatrics and for the treatment of patients with congenital enzymatic insufficiency of glucose-6-phosphate dehydrogenases, epileptics and persons with pathological changes in tendons after the course of drugs of this group.

Macrolred antibiotics of the second stage (clarithromycin, midekamycin, roxitromycin) are not used to treat future moms and breastfeeding patients. Josamamicin and Spiramycin, which can be used to treat chlamydia during pregnancy, are not prescribed during lactation.

The ban on the use of any macrolides serve severe liver dysfunction and biliary tract.

Side effects of antibiotics during chlamydia

Antibiotics cause all sorts of allergic reactions from itching skin rashes and swelling to severe bronchial asthma and anaphylaxis.

The general actions of antibiotics include work disorders digestive organs - dyspeptic phenomena, abdominal discomfort, lack of appetite, stomatitis, colitis, violation of the intestine microflora, in addition, fluoroquinolones can still cause perforation and intestinal hemorrhages, as well as various disorders of the liver, jaundice, moderate cholestasis. On this list of side effects of macrolide antibiotics ends.

Doxycylin and fluoroquinolones can cause changes in blood formula: reducing the level of erythrocytes, platelets, neutrophils, hemoglobin; pancytopenia, eosinophilia; The use of the latter may cause point or larger hematomas, nasal bleeding.

These drugs are able to provoke the development of superinfection, reinfection, mycoses, the appearance of the strains of bacteria resistant to them, photosensitization phenomena.

Doxycyllin causes a resistant change in the color of the enamel of the teeth.

The longest list of side effects have fluorinated quinolones. In addition to the already named, these drugs may cause:

• metabolic and metabolic disorders;
• mental disordersshown in an overexcited state, insomnia and nightmares, paranoid and depressive disorders, phobias, disorientation in space, suicide attempts and others;
• violations of the central and peripheral nervous system;
• visual disorders (light-free, diplopia, conjunctivitis, nystagm);
• hearing impairment and coordination of movements;
• heart disorders up to its stop and cardiogenic shock, cerebral vessel thrombosis;
• disorder work of respiratory authorities up to the respiratory stop;
• pain in muscles, joints, tendons, damage and breaks of their tissue, and during the first two days of reception of the drug; muscle weakness;
• all sorts of disorders of the urinary organs, candidiasis, the formation of kidney stones;
• in patients with hereditary porphyria - aggravation of the disease;
• in addition, asthenic syndrome, back pain, hyperthermia, fever, weight loss, taste perversion and smell perception.

Method of application and dose

The most commonly appointed course of antibiotics during chlamydia:

a single azithromycin intake in a dosage of 1000 mg (two tablets of 500mg) an hour before meals or a seven-day course of doxycycline for 100mg (one capsule) every 12 hours, rich in water.

The preparations of the second line are taken within a week:

Erythromycin - every six hours of 500 mg per hour before meals eating abundantly drinking water;

Josamicin - every eight hours of 750mg;

Spiramycin - every eight hours of 3 million;

Offloxacin - every twelve hours of 300 mg;

Ciprofloxacin - every twelve hours of 500-750 mg in complicated cases.

Pregnant women are prescribed conventional erythromycin therapy schemes, Josamamicin, Spiramycin.

During treatment, it is necessary to observe sufficient water regime (at least 1,5 liter of water per day).

The course of treatment is obligatory for both partners. In complicated cases, two antibiotics of different pharmacological groups can be used, for example, azithromycin or doxycycline in combination with ciprofloxacin.

An indicator of the effectiveness of the treatment is considered the negative result of the polymerase and chain reaction of the smears of the urogenital tract after one and a half or two months after the end of treatment.

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Overdose

Exceeding the dose of macrolides is manifested by symptomatics of the disorder of the digestive system (diarrhea, nausea, abdominal pain, sometimes - vomiting).

Overdose by doxycycline or fluorinated quinolon is manifested as a neurotoxic reaction - dizziness, nausea, vomiting, cramps, loss of consciousness, headache.

Treatment: stomach wash, activated carbon.

Interactions with other drugs

This factor must be considered to achieve maximum efficiency from medical treatment and neutralize negative effects that arise.

Basically, mutual influence macrolide Antibiotics with various drugs is associated with inhibiting these drugs of cytochrome P-450. The ability to oppress this system increases in the specified group of antibacterial agents in such a sequence: Spiramizin → Azithromycin → Roxitromycin → Josamamicin → Erythromycin → Clarithromycin.

With the corresponding intensity, the representatives of this pharmacological class slow down the biological transformation and increase the serum density of indirect anticoagulants, theophylline, finlepsin, hollows, dyspepiramide derivatives, drug-based drugs, cyclosporine, respectively, increasing the likelihood of development and the strength of the side effects of listed drugs. Therefore, it may be necessary to change their dosing regime.

It is unwanted simultaneously macrolide antibiotics (an exception is spiramsycin) with preparations of fexophenadin, cisapride, astemisol, since this combination significantly increases the risk of severe arrhythmia caused by the elongation of the Qt interval.

Antibiotics of this series contribute to the improvement of the absorption of oral digoxin, as it reduces its inactivation in the intestine.

Antacid drugs reduce the absorption of macrolide antibacterial agents in the digestive channel, in particular, this influence is subject to azithromycin.

The anti-tuberculosis antibiotic rifampicin accelerates the process of biotransformation of the macrolides of the liver and, accordingly, reduces their plasma concentration.

The use of alcohol in the process of treatment with any antibiotics is unacceptable, but it should be taken into account that erythromycin, especially its intravenous injections, increase the risk of acute alcohol intoxication.

Suction Doxycycline reduce antacid preparations and laxatives, as part of which there are salts of magnesium, antacids containing aluminum and calcium salts, medicinal and vitaminatives containing iron, sodium bioharged, cholestiramine and bears, so when they are combined, the reception is bred by time, making the interval not less than three hours.

Tact as a drug violates intestinal microbiocenosis, thrombocytopenia and a change in the dose of indirect anticoagulants is required.

Simultaneous reception with penicillin and cephalosporinic bands, as well as other, the mechanism of action of which is based on a violation of the synthesis of the bacterial cell shell, is inappropriate, since it leveals the effect of the application of the latter.

Increases the risk of unwanted pregnancy in combination with the reception of estrogen-containing means of contraception.

Substances activating microsomal oxidation process ( ethanol, barbiturates, rifampicin, Finlepsin, phenytoin and others) increase the sweep rate of doxycycline and reduce its serum concentration.

The combination with methoxyphluorone is fraught with the danger of developing acute renal failure and even the death of the patient.

Reception of vitamin A Against the background of doxycycline therapy, an increase in intracranial pressure can provoke an increase in intracranial pressure.

Simultaneous inclusion in the reception scheme fluorinated Hinolonov With medicines, which contain bismuth, zinc, iron ions, magnesium is digested significantly worse due to the creation of non-absorbing chelate compounds with them.

Ciprofloxacin, norfloxacin and peffloxacin reduce the removal of methyl derivatives xanthine (theobromin, parasanthine, caffeine) and increase the likelihood of mutual toxic effects.

The neurotoxic effect of fluorinated quinolones increases with combined use along with non-steroidal anti-inflammatory agents, as well as nitroimidazole derivatives.

Nutrofuran medications are not compatible.

Ciprofloxacin and norfloxacin have the ability to upset the biotransformation process in the liver of indirect anticoagulants, as a result of which the likelihood of blood liquefaction and hemorrhagic phenomena increases (there may be a need to adjust the dose of the anti-tomb drug).

Fluoroquinolones are not prescribed in one diagram of reception with cardiac means, increasing the Qt interval due to the high probability of heart rhythm disorders.

Combined use with glucocorticoid hormones is dangerous highly likelihood of tendons in the group of high risk - patients of old age.

The purpose of ciprofloxacin, norfloxacin and peffloxacin on the background of taking drugs with the effect of urin's peeling effect (sodium bicarbonate, citrates, carbicanhydrase inhibitors) increases the likelihood of the formation of concretions and the nephrotoxic influence of such a combination of medicines.

Against the background of the intake of azlocillin or cimetidine due to the decrease in the channel secretion, the rate of removal from the body of fluoroquinolone row antibiotics decreases and their plasma concentration increases.

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Information for patients

It is necessary to comply with the conditions for storing the drug and the shelf life that are specified on the package. In no case do not use medicines, the shelf life of which has expired or has changed appearance drug (color, smell, etc.).

Currently, macrolides are positioned as the most effective antibiotics during chlamydia. They have the highest ability among other antibacterial drugs penetrate the cells and affect the pathogens settled there. They are effective, the microbes have not lost sensitivity to them. Low toxicity of the macro-group antibiotics is also a positive factor in favor of their application. However, a single approach to all patients does not exist and can not be, since many factors affect the choice of treatment regimens - from individual tolerance to the degree of nestness of the disease and the patient's health status.

Treatment, as practice shows, does not always turn out to be effective. And often the question arises, why not pass the symptoms of chlamydia after antibiotics? There are many reasons for this. First of all, the irresponsibility of the patient himself. Not everyone is strictly implementing medical prescriptions, adhere to the reception mode during the entire therapeutic course. And also withstand its duration and do not stop treatment without control analyzes.

In addition, both partners must be treated. Chlamydia can be infected with the countless number of times, especially if the source of the infection is nearby.

During the course of treatment, it is necessary to refrain from sex. If you have taken azithromycin once, then it is necessary to make sure to make sure your crosses in your crosses. It is recommended in three months or later to undergo a control examination to make sure that the pathogen is destroyed.

If the symptoms returned again, it is necessary to consult a doctor. Repeated infection is fraught with serious complications.

Often the question arises: how to cure chlamydia without antibiotics? Official answer: Eradication of chlamydia without antibiotics is still impossible. Science does not stand still, however, such treatment is the task of the future. True, there are several options for the treatment of chlamydia herbs and biodevices on the Internet. It is not prohibited by alternative methods to anyone, just need to consider that, tightening the process, you risk complicating the course of the disease, and then get rid of it will be much more difficult.

Chlamydia is a difficult disease for the reason that even after prolonged treatment, the recurrence of this disease is likely. Covering into a chronic stage, he is able to develop immunity to a number of diseases.

This makes the treatment of chlamydia in men with antibiotics useless. Antibiotics from chlamydia in women may also not bring the desired effect as a result of chlamydia mutation.

Therapy should be comprehensive and based on the individual characteristics of the patient's body. Moreover, other venereal and urogenital diseases can also contribute to the emergence of inflammatory processes.

Doxycycline is effective, but in large quantities is dangerous for the digestive system

Difficulty treatment is that antibiotics against chlamydia are strong only when therapy disease in the reticular stage. Another "sleeping" chlamydia is not destroyed by medicine and can develop immunity to it. For this reason, the observance prescribed by the attending physician is extremely important.

But the complexity of treatment does not cancel that the basis on which therapy is built is still antibiotics for the treatment of chlamydia. Only in cases where the individual intolerance between antibiotic drugs exist, a doctor is prescribed other treatments, but such cases are quite rare.

Plan of therapy

The graph of receptions is built depending on the clinical form of the disease. You can break the treatment at several main stages:

1. Preparatory. This stage lasts about a week. Preparation includes the strengthening of immunity, which is carried out by the use of immunostimulating drugs. Localized rejection of the affected areas with the use of chlorhexidine is also carried out.
2. Main. It lasts up to 2 weeks. This is a period of main treatment when all the antibiotic and antifungal agents are applied.
3. Recovery. During it, the body establishes the work of the liver and intestines, which specially assigned drugs to restore microflora are helping.

Treatment of chlamydia in two sexual partners can vary significantly

However, if the disease passed into chronic staging And characterized inflammation of genital organsThe treatment plan may change somewhat:

1. First treatment is carried out antibiotics, antioxidants, immunostimulating drugs and vitamins. A week later, the therapy is connected Enzymes and antifungal agents.
2. A week later in the course of hepatoprotectors, as well as the patient goes to physiotherapeutic procedures.

What antibiotics treat chlamydia

Immunomodulators and tetracyclines

First go to move immunomodulators, preparations like Polyoxidonium With chlamydia, they manifest themselves very well. In some cases, it can be appointed to receive and Erbisolwhich is also a hepatoprotector.

Then go into the move itself antibioticsfrom chlamydia in men and women. There are several basic groups of antibiotic drugs in this case. With not very hard lesions, the doctor most often recommends taking something from the tetracycline group during chlamydia.

The most popular . However, its use with insufficiently severe immunity can cause digestive disorders and the appearance of thrush and in women. That this does not happen, should pay due attention to the previous stage of treatment.

Preparations from a group of tetracycline besides nausea can cause a violation of bone fabric and enamel, so they are categorically contraindicated by small children, as well as pregnant and nursing women.

The choice of drugs for therapy should be entrusted to the doctor

Also among tetracycline antibacterial drugs can be mentioned , Vibreamicin, Dorix other. All of them are quite effective in the destruction of chlamydia, however, still not as macrolides.

Macrolids

MacrolidsPerhaps the safest and most reliable method of therapy when infected with chlamydia. Moreover, such funds as Erythromycin and Rovamicin You can apply during pregnancy. Other known drugs of this group can be called Josamamicin, Clarithromycin, Roxitromycin (RULID), spiromycin, mirdekamicine and azithromycin.

For a long time, doctors prescribe erythromycin during chlamydia. It is more effective than AzithromycinHowever, it can cause a greater number of negative side effects expressed in a temporary deterioration of well-being. Azithromycin, in turn, can be applied to the concomitant syphilis or a developed gonorone-chlamydial infection.

Each of the drugs of the group of macrolides has high efficiency, and also has its dosage of reception. It is imperative to consult with a specialist before applying medicines. During therapy. You should also take into account the possible side effects and contraindications, individual in each case.

Fluoroquinolones

Another group of drugs used to track and destroy chlamydia are drugs known as fluoroquinolones. These drugs are cheaper and less effective than macrolides and tetracycles. However, they are able to fulfill the role of support in the treatment of mixed infectious diseases.

During pregnancy, choose medicines with caution

The disadvantage of this group of medicines can be considered a large number of negative side effects. Also, their use is unacceptable in the treatment and pregnant women.

Fluoroquinolones are second-order preparations, which makes macrolides more preferable. However, in the treatment of resistant and chronic infection, they have quite by the way.

Anyway, before applying certain medicines, you must consult with your attending physician. Chlamydia is a cunning disease that can be recurred with ease. It is extremely important to observe the therapeutic course in its entirety and duration to destroy chlamydia once and for all.

In contact with

The treatment of chlamydia is distinguished by its features:

• antibiotics dosages are quite high;
• often several courses are prescribed by different drugs;
• antibacterial therapy is combined with the reception of immunomodulators;
• antibiotics from chlamydia are prescribed in the acute phase of the disease.

The pharmacological industry suggests wide spectrum Antibacterial agents, however, choose the drug and calculate the adequate dosage is not easy. In each case, the doctor is suitable for the development of the treatment regimen individually. After all, chlamydial infection can be burdened with other infectious processes, and the immunity has different patients.

The situation is also aggravated by the fact that the drug does not act during the re-treatment of chlamydia - they adapt to its formula. If the patient had previously overdone the infection, it is necessary to pick a different drug with the same action, but another dosage formula.

In addition to the reception of capsules and injections, local destination - suppositories, ointments and creams are used.

If it is impossible to defeat the infection with the selected treatment regimens, the patient take a test on the bacterial strain to find out the cause of drug resistance. It takes time and costs money. However, only after a laboratory study, a suitable drug can be selected.

Rules of treatment

Patients should understand that treatment with antibacterial agents implies strict adherence to certain rules, otherwise the effect will not be achieved. Bacteria behave like quite reasonable creatures and are trying to survive in all conditions, therefore only strict adherence of the verified dosage and the medication scheme will help to defeat the infection.

Follow the instructions:

• medications are accepted strictly at the appointed time;
• after the symptoms disappear, the reception of antibiotics continues the time specified by the doctor;
• the course is prescribed to both sexual partners, even if one of them has no signs of infection;
• before starting treatment, all relying analyzes should be handed over, on the basis of which the treatment regimen will be developed;
• at the time of treatment, sexual activity is completely excluded.

Remember that neglects one of the items instructions will entail unpredictable results.

The diagram of treatment with antibiotics from chlamydia in men and women is the same. Dosage of drugs is determined individually.

Scheme acute flow Diseases implies three stages:

• preparation of an organism for receiving antibiotics with immunomodulators and processing of infected sections with chlorhexidine;
• the use of prescribed drugs - 7/10/14 days;
• restoration of broken intestinal microflora, liver cells.

Chronic flow changes the therapeutic procedures:

1. The first stage involves the use of antibacterial agents together with immunomodulators, antioxidants and vitamin complexes.
2. The second stage consists in the use of funds against fungi and enzymes.
3. The third stage is to receive recovering liver medications, as well as visiting physiological.

Thus, the chronic stage is subject to three-week exposure to drugs, the sharp form is treated within two weeks. The duration is due to the destruction of chlamydia at all stages of development.

Description of drugs

Antibacterial drugs have either a wide range of action, that is, destroy bacteria throughout the body, or struggle with individual types of microorganisms. In the case of the treatment of chlamydia, drugs are needed that can destroy bacteria in intracellular structures. However, chlamydia is complicated by the addition of other forms of microorganisms, which, together with it, attack the reproductive human bodies and cause strong inflammatory processes.

Therefore, doctors prescribe a complex of drugs capable of fighting with all kinds of genital infection. For this, there are three large groups of medicines:

1. tetracyclines;
2. fluoroquinolones;
3. macrolids.

Other medicines cannot have an adequate effect on these microorganisms, therefore the effectiveness does not differ. Incorrectly chosen medications will not only positive influence The course of healing, but can help enhance the activity of bacteria and their reproduction.

Tetracyclines

Tetracycline and doxycycline, as its derivative, can overcome a fresh infection in the body, which has not yet managed to strengthen their positions. Tetracycline preparations are prescribed to use 400 mg x 4 times for a week / two. Doxycycline has a different scheme - 100 mg x 2 times a day.

Doxycycline is considered the most effective in chlamydia, however, has strong side effects. These include the disorder of the functionality of the gastrointestinal tract, and the occurrence of thrush, stomatitis or glossite. However, this applies to patients with strongly weakened immune defense.

Note! Tetracycline group preparations destroy the bone structure and enamel of teeth. Children these drugs are prescribed after eight years, they are pregnant, they are contraindicated.

The following active antibiotic is azithromycin. This drug also causes undesirable side effects associated with the disorder of the gastrointestinal tract, so before use should be tested for sensitivity. When strengthening side effects, you should notify the doctor. In case of intolerance to the drug, the doctor will select less efficient, but safe for the body.

UNIDS SOLUTAB based on Doxycycline monohydrate is best tolerated by patients, since it does not have a strong negative effect on the body. It is recommended to use patients with gastric problems - does not irritate the mucous membrane.

Macrolids

This group of drugs is not so toxic as tetracyclines, but no less effective. Medicines are well tolerated by patients and do not have a pronounced side effect.

Note! Antibiotics of the macrolide groups are best tool Treating chlamydia.

Among the macrolides, you can choose many drugs, such as Sumamed, erythromycin or macropen. Erythromycin is taken according to the scheme 500 mg x 2 times or 250 mg x 4 times over seven days. However, this antibiotic is often poorly tolerated by patients, as it has a high degree of toxicity.

However, when applying ointments, it is necessary to bring treatment to the end, otherwise the ragless infection will become more active than with primary infection.

Important! Antibiotics with chlamydia in men can not be combined with alcohol and spicy food.

Patients are more often prescribed by rovamicine, which has a minimum toxic effect on the body and well-stopping inflammation in the foci. This antibiotic can also take pregnant women.

Sumamed is very effective when dealing with chlamydia, besides, it suppresses the activity of gonococci. Sumamed prescribed both gonor. The active substance of the drug has the ability to accumulate in affected foci, while maintaining resistance to five days. The treatment regimen involves taking medication in one capsule of 500 mg for a week or 250 mg - two weeks. This defines the doctor.

Fluoroquinolones

Fluoroquinolones are used when the first two groups of antibiotics from chlamydia did not have an effect in treatment. In this case, ophloxacin is most often prescribed, which is used once a day at 400 mg or twice with 200 mg. The duration of admission to nine days. The drug Ciprofloxacin is also prescribed, but it is less likely to this dosage formula, most strains are stable.

Preparations of this group are successfully used in the treatment of mixed infections and chronic infections. However, drugs cannot be used to destroy chlamydia in pregnant women and young children.

Antifungal agents

Since fungi is often joined to chlamydias, patients are discharged and antifungal drugs. The activity of fungi is caused by a disruption of the microflora balance in the body, since antibiotics destroy all bacteria without parsing. Mushrooms get fertile soil for breeding.

Among antifungal agents Distribution received the following medicines:

• Trichopol;
• Metronidazole;
• Fluconazole;
• Natamicin;
• others.

Immunomodulators

Usually prescribed a drug of polyoxidonium, which shows itself well in the treatment of genital infections. Erbisol, in addition to strengthening immunity, has a beneficial effect on liver cells. Immunomodulators are injected intramuscularly. Also may prescribe interferon group and enzyme preparations.

The latter exempt the body from toxic substances produced by bacteria and strengthen immune system. To support the liver, use Forte or Carsil essentially.

Probiotics

This group of drugs is prescribed to restore the broken intestinal microflora. The violation is caused by the use of potent drugs that destroy and useful bacteria along with malicious. If you do not apply probiotics, the problems with digestion and intestines are inevitable. As a rule, the patient suffers from the disorder of the chair - diarrhea.

List of useful probiotics:

• Lactobacterin;
• Bifiform;
• Bifidobacterin;
• Linex;
• Enterol;
• Bificol.

These drugs cannot be applied independently - only after the doctor's approval. They have live bacteria that help proper food processing.

Physiosparces and baths

Antibiotics in chlamydia in women and men complement the appointment of physiotherapy and local therapy. Baths with chlorhexidine make it easier and quickly remove the symptoms. Also apply different disinfectants For the formulation of micro clisisms.

Physiosparces accelerate the recovery of the body. For this purpose, electro- and laser meterosis, magnetotherapy, procedure using ultrasound are prescribed.

After the end of the therapeutic course, the patient must pass tests to make sure the effectiveness of the treatment. The analyzes include:

Treatment of chlamydia antibiotics: What are the best, effective against chlamydia?

Antibiotics during chlamydia are prescribed strictly individually, therefore even sexual partners passing at the same time treatment can use different means that the doctor assigns after a preliminary sensitivity test. That is why an unequivocal answer to the question of which antibiotics in chlamydia will be most effective, does not exist. The best medicine will be that the doctor considers it necessary to prescribe, and the name of the antibiotic can differ, but also its dosage, which is determined by the test results. Men and women, passing a course of treatment with chlamydia, should understand that for effective struggle With the disease, it is important to accurately comply with the recommendations given by the doctor, otherwise even the most best medicine May be powerless.

As a rule, despite the fact that the antibiotics in chlamydia can be assigned different and in composition, and by dosage, the recommendations are most often almost identical:

• Take appointed antibiotics follows at the same time;
• The course of treatment should continue as much as the doctor counted, even if the effect of the started treatment has manifested itself quite quickly;
• In the overwhelming majority of cases, it is recommended to take medicines from chlamydia to both sexual partners at the same time. If one of the partners have found chlamydia, antibiotic treatment needs to be second, regardless of whether he has symptoms of the disease;
• The sensitivity of chlamydia to antibiotics may vary in different periods of human life, so until the drug should pass all the surveys, which the doctor considers it necessary, otherwise the treatment may not be effective enough, and the disease will be aggravated by the disease;
• Sexual relationships on the use of antibiotics against chlamydia should be stopped.

What antibiotics are chlamydia?

To date, the most effective tool Antibacterial therapy of chlamydia is considered doxycycline. And indeed, medical practice proves that if it is not the most effective antibiotic with chlamydia, the best of all known - for sure. According to a large number of doctors, doxycycline could boldly claim the title of the best antibiotic in chlamydia if it were not for the number of side effects that may arise from those who should take it. To such consequences, both women and men include various disorders of the digestive tract, and in addition, they often become the appearance of thrush in women. However, when testing the sensitivity test, it is Doxycycline often turns out to be one of the most appropriate means.

The second appointment is azithromycin. Despite the fact that it can also cause such side effects as vomiting and nausea, azithromycin is conditionally in second place among the best antibiotics from chlamydia. However, doctors warn that before starting to take this drug, it is necessary to take a test for sensitivity, and during treatment it is important to pay attention to the strengthening of side effects and in the absence of the possibility of controlling them - to contact medical help. As a rule, in this case, a re-test for the sensitivity of chlamydia is carried out, according to the results of which antibiotics may be prescribed, which may not be as effective, however, do not cause a large number of side effects in women and men.

Other antibiotics against chlamydia

As mentioned, antibiotics in the treatment of chlamydia in no way can be taken independently either on the recommendation of any of the acquaintances who have undergone this disease. Currently, there is a fairly large amount of antibacterial drugs in pharmacology, and the optimal choice of one of them can be done only on the basis of the test of sensitivity, taking into account all existing factors that may affect the effectiveness of treatment. Among the most popular can be called the following:

• Clastide is a semi-synthetic antibacterial drug from the group of macrolides, the treatment of them usually continues from three to 14 days, most often the effectiveness is quite high;
• Macropen is a macrolide antibacterial agent, allowed for the treatment of sex infections during pregnancy (after 20 weeks);
• RULID - semi-synthetic macrolide antibacterial drug;
• Clabaks is a semi-synthetic macrolide agent of the last generation;
• Ceftriaxone is a cephalosporin antibacterial agent of the third generation;
• Amoxicillin is rarely prescribed for the treatment of chlamydial infection;
• Amoxiclav - the drug, most often appointed during combined sex infections;
• Rovamicin - tetracycline antibacterial drug;
• Josamamicin - a new generation macrolide, has fewer side effects;
• Vilplerafen - Mkrolid from the group of new generation, is used to treat all urogenital infections;
• Sumamed is a highly efficient drug with a small number of side effects;
• Chemomycin - a macrolide semi-synthetic antibacterial drug;
• Unidox Solutab - a tetracycline antibacterial drug, an alternative to patients with urogenital infection in the intolerance to other groups of antibiotics;
• Erythromycin - many times proved effectiveness in the fight against urogenital infections;
• Clarithromycin is a macrolide antibacterial drug, often used for the treatment of genital infections.

Despite the fact that there is a sufficiently large amount of information on which antibiotics to drink with chlamydia, I would like to once again focus on the fact that every person is individual, and therefore the treatment that could be effective for another, he can, in best, not to help, and at worst - significantly worsen the state of health. Therefore, the decision on which antibiotics to take in chlamydia to this or another patient is made exclusively by the doctor on the basis of the results of a detailed examination. Even the antibiotics from chlamydia in women and men, not to mention the sensitivity and some other important factors, are often appointed different.

Questions

Question: What antibiotics need to be taken to treat chlamydiasis?

What antibiotics is treated with chlamydia?

Antibiotic therapy is a key treated direction chlamydiosis. It is antibacterial drugs directly affect the causative agent of the disease, preventing its growth and reproduction. However, during chlamydiasis antibiotics should be used with caution. The fact is that the disease can flow both acutely and latent, without explicit symptoms and manifestations. Usually it speaks of chronic flow of chlamydia.
In the inactive phase of the bacteria is almost immune to any medicaments. At the same time, resistance to antibiotics may develop. Therefore, the course of antibacterial drugs during chlamydia should appoint a doctor after all necessary analyzes.

In the treatment of chlamydia, antibiotics pay attention to the following features:

• High doses. The treatment of chlamydia is applied relatively high doses of antibiotics. This is due to the need to quickly kill the causative agent of the disease so that he does not have time to go to the protective L-form.
• Combining drugs. In the chronic course of chlamydia, there may be needed several antibiotic therapy courses. From one course to another drugs may change.
• Reception of immunomodulators. The intake of immunomodulators stimulates the body's immune system to produce specific antibodies against chlamydia. This increases the effectiveness of antibiotic therapy.
• Periodic reception. Usually doctors try to prescribe antibiotics by courses that correspond to the phases of exacerbation of the disease. In this period of time, chlamydia is most sensitive to drugs. With a recurrent course with the phases of remission ( attitude symptoms) and exacerbations need periodic antibiotics.

If you speak directly about the sensitivity of chlamydia to antibiotics, then a fairly wide range of medicines is suitable for treatment. Difficulties more often arise with the correct selection of doses and accurate determination of the phase of the disease. Selection of drugs can cause difficulties in those patients who have already treated chlamydia in the past. Their bacteria strains can be resistant to previously used drugs. However, here you can find a way out. In such cases, it is resorted to the cultivation of chlamydia taken from the patient in laboratory conditions. This analysis is relatively time consuming, long and expensive, so it is not used for each patient, but only if necessary, at the discretion of the doctor. The grown colony allows you to determine the sensitivity of chlamydia to various drugs and choose those of them that are most effective.

Standard preparations with chlamydia treatment are the following groups of antibiotics:
1. Tetracyclines.
2. macrolides;
3. Fluoroquinolones.

Tetracyclines.

Tetracycline itself is used from this group of drugs ( 500 mg 4 times a day for 1 - 2 weeks). However, this antibiotic is dangerous due to possible side effects. He is not prescribed to children or pregnant women. Somewhat lower doses ( 100 mg 2 times a day) Requires doxycycline, so it can more often meet in medical practice in the treatment of chlamydia. Doxycycline treatment duration is also 7 - 14 days.

Macrolids.

Macrolides are widely used for the treatment of chlamydia in both adults and children. In most cases, they effectively defeat the disease in the acute phase, not allowing chronic. In the treatment of chronic infection, a mutual replacement and combination of drugs of this group is possible. Directly macrolides and their dosage in the treatment of chlamydia are presented in the table.

Dosage of macrolides in the treatment of urogenital chlamydia in adults and children.

Treatment of chlamydia - drugs, chlamydia treatment schemes

To date, the problem of treatment of chlamydiasis for many doctors and patients has great difficulties, since often after therapy with antimicrobial means after a certain time, the manifesting of this insidious disease.

The problem is that the majority of patients are recorded chronic urogenital chlamydia, treatment with drugs is quite often ineffective.

What is the danger of chlamydia?

Chlamydia Trachomatis (chlamydia trachomatis) most often causes the following pathologies of the urogenital tract:

• ureterites in men and women (over half of all non-nodococcal urethritis),
• prostatitis and orchoepididimitis in men, Cervicitis, Salpingitis, Endometritis,
• combined deviations of organs are often observed (for example, urethritis, arthritis and conjunctivitis in the Reiter syndrome program).

At the same time, there is a fairly extensive list of laboratory methods for diagnosing chlamydia, although the most reliable methods today are recognized methods of immunophorement analysis with monoclonal antibodies (used deoxygenated blood) and PCR diagnostics (more often than the endylony of the urogenital tract).

In the treatment of chlamydial infection, as in the depreciation of other infectious processes, the tasks of the eradication of the pathogen and the disposal of acute or chronic inflammation Genitals and urinary tract, which reduces the quality of life. The target to reduce mortality from chlamydiosis, fortunately before the urologist, a gynecologist or a venereologist, as it is not necessary to die from chlamydial infection of the urogenital tract very problematic.

An interim target may be to avoid chroniosis chroniosis, a decrease in the number of recurrences of chronic chlamydial process, as well as a decrease in the number of articular and eye complications of urogenital chlamydia. You can talk about the desire to reduce the number of complicated or unwanted pregnancies against the background of chlamydia and the avoidance of postchlamydial infertility both in women and in men.

Selection of drugs in the treatment of chlamydia

With an active inflammatory process, a whole range of medicines requires a full-fledged course of chlamydia treatment. The drugs used in the treatment regimens are selected by the doctor taking into account the individual characteristics of the patient's body, clinical symptoms of the disease, the severity of the inflammatory process and the results of all analyzes - immunograms, hepatic samples, the general analysis of blood, urine sowing, PCR, IFA results, and laboratory data.

Today, treatment standards do not imply the appointment of immunostimulants or immunomodulators in the treatment of even complicated chlamydia. Preparations of these groups, with the exception of serious cytostatic drugs with strict readings and appointed only after the implementation of the immunogram, should not be used as drugs with an unproved action. The shamanism of a large number of urologists, venerenolgs or gynecologists in this area is often due to bonuses from pharmaceuticals or an attempt to lengthen and express treatment for patients with paid clinics and medical centers.

All information O. medicinal preparations and treatment diagrams are intended for reference. Treatment of chlamydia is prescribed only by a qualified physician according to the results of analyzes, taking into account the history of the patient, concomitant diseases, etc.

Tactics Eradication Chlamydia

Eradication - there is essentially getting rid of the body from an infectious agent. Chlamydia is a resident of intracellular, which besides its main form to exist in the L-version (vegetative), which is not able to without significant suppression of the host immunity to the output from the cell and the reproduction, which runs away from the effects of antibacterial agents or physical effects (temperature increase). The preparations of three antibacterial groups are inhibited with chlamydia: tetracycline, macrolides and fluoroquinolones.

It is worth noting that before the beginning of therapy of sowing chlamydial cultures to determine the sensitivity to antibiotics is not appropriate, since the studies held in 2000 on the bases of obstetrics and gynecology them. D.O.otta Ramne, St. Petersburg, Physics and Chemical Medicine Medicine of the Ministry of Health of Russia, Moscow, Institute of Clinical Bacteriology of the Uppsa University, Sweden, showed that strain-resistant strains maintained their sensitivity to antibiotics in patient organism.

Antibiotics in chlamydia

Antimicrobial means are basic in the treatment of chlamydia. And as a rule, with chronic chlamydia, treatment with drugs is to apply a combination of 2 antibiotics. The duration of the course of treatment, the individual dosage is determined by the attending physician depending on the type of disease, the dynamics of the inflammatory process.

When choosing an antibiotic with chlamydiasis, laboratory data is indispensable to determine the sensitivity of the pathogenic microorganism to a specific antibacterial drug. Therefore, it is advisable to supplement the antibioticogram, culture methods of laboratory diagnostics.