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Gross formulaC 10 H 15 NOPharmacological group of substance EphedrineNonological Classification (ICD-10)CAS code299-42-3Characteristics of Ephedrine substanceEphedrine - Alkaloid contained in various types of ephedra (Ephedra L.),ephedrov family (Ephedraceae). Ephedrine Hydrochloride - White Needle Crystals and White Crystal Gorky Taste Powder. Easily soluble in water (1: 5), soluble in alcohol (1:14), practically insoluble on the air and chloroform. Pharmacologypharmachologic effect - vasoconstrictor, hypertensive, bronchophold, hyperglycemic, psychostimulating.Stimulates alpha and beta-adrenoreceptors, inhibits the activity of Mao and Catecholamino-orthomethyl transferase. It has a positive other, chrono-, dromo and batmostropic effect. The use of substance EphedrineBronchial asthma, hay fever, urticaria, serum disease and others allergic diseases, rhinitis, hypotension (operations, spinal anesthesia, injuries, blood loss, infectious diseases, hypotonic disease, etc.), narcotonia, pioneering and narcotic poisoning, enuresis; Locally as a vasoconstrictor, to expand the pupil (with a diagnostic target). ContraindicationsHypersensitivity, insomnia, hypertension, atherosclerosis, organic diseases Hearts, hyperthyroidism. Side effects Ephedrine substanceLight trembling, heartbeat (15-30 minutes after intake); Sleeping, increased blood pressure, nervous arousal, tremor, urine delay, loss of appetite, vomiting, reinforced sweating, insomnia, rash. Ephedri on hydrochloride
Contraindications: Side effects: ondivision S. on Method of use and dose: ononi am 0.15 Special instructions:Do not do it onz. on
Solutan Pharmachologic effect:Broncholitic, expectorant. Contraindications:Hypersensitivity, glaucoma, atherosclerosis, increasing the prostate gland. Application in pregnancy and breastfeeding:With caution, because part of the drug ontriah Yodid and Radobelin penetrate the placental barrier, and Belladon on stands out with maternal milk. Side effects:Head oni am pain, ataxia, anxiety, ondivision S. on, nausea, vomiting, epigastric pain, diarrhea, dry mouth (at high doses), tachycardia, heart pain, ventricular arrhythmia, increase hell, muscular oni am weak, strengthening sweating, expansion of pupils, contact dermatitis. Method of use and dose:Inside, after a meal, 10-30 drops 2-3 times a day (when choking the dose arrogant to 60 drops on reception). Children from 12-15 years old - 5-10 drops 2-3 times a day. It should be borne in mind that the appearance of turbidity or sediment during storage is not an obstacle to the use of the drug.
Ephedri on hydrochloridea solution Effective (Ephen) Ephedrine (Ephedrine)
Contraindications:Hypersensitivity, insomnia, hypertension, atherosclerosis, organic heart disease, hyperthyroidism. Side effects:Light trembling, heartbeat (15-30 minutes after intake); ondivision S. on, increase blood pressure, nervous arousal, tremor, urine delay, loss of appetite, vomiting, reinforced sweating, insomnia, rash. Method of use and dose:P / k, V / m, adults - 0.02-0.05 g 2-3 times a day. V / B, stove (slow) - 0.4-1 ml of 5% solution or drip in total dose - up to 0.08 g (in 100-500 ml of isotonic solution onchloride tillage or 5% glucose solution). Higher doses for p / k administration: one-time - 0.05 g, daily oni am 0.15 Special instructions:Do not do it onz. onephedrine and containing its preparations before bedtime.
Ephedri on hydrochloridea solution for injection 5% Effective (Ephen) Ephedrine (Ephedrine)
Contraindications:Hypersensitivity, insomnia, hypertension, atherosclerosis, organic heart disease, hyperthyroidism. Side effects:Light trembling, heartbeat (15-30 minutes after intake); ondivision S. on, increase blood pressure, nervous arousal, tremor, urine delay, loss of appetite, vomiting, reinforced sweating, insomnia, rash. Method of use and dose:P / k, V / m, adults - 0.02-0.05 g 2-3 times a day. V / B, stove (slow) - 0.4-1 ml of 5% solution or drip in total dose - up to 0.08 g (in 100-500 ml of isotonic solution onchloride tillage or 5% glucose solution). Higher doses for p / k administration: one-time - 0.05 g, daily oni am 0.15 Special instructions:Do not do it onz. onephedrine and containing its preparations before bedtime.
Broncholitin Method of use and dose:Inside. Adults - 1 tbsp 3-4 times a day; children over 3 years - 1 h. Such 3 times a day; children over 10 years - 2 h. Such 3 times a day.<
Bronarchycin Method of use and dose:Inside, adults - 1 tbsp 3-4 times a day.
Glauzi on hydrochloride Active ingredient (MNN) Glaucine (Glaucine)
Contraindications:Hypersensitivity, arterial oni am hypotension, myocardial infarction, hyperproduction of sputum. Side effects:Hypotension, dizziness, weakness, nausea, allergic reactions. Method of use and dose:Inside, after eating, adults - 40-50 mg 2-3 times a day; To suppress night cough in severe cases - 80 mg on night; Maximal oni ship oni am a dose - 200 mg; Children depending on age - 10-30 mg 2-3 times a day.
Active ingredient (MNN) Iohimby on hydrochloride Yohimbine Hydrochloride) Contraindications:Hypersensitivity, pronounced onkidney / liver function, blood pressure, uncontrollable hypo-/ hypertension, simultaneous intake of adrenomimetics. Restrictions on use:Violation of the function of the cardiovascular system, Yazzen oni am a disease of the stomach and two onmonastery in a onmuseum, onlisting mental diseases. Side effects:Excitation, tremor, heads oni am pain, dizziness, anxiety, irritability, increased blood pressure, tachycardia, orthostatic collapse (for large doses), enhancing motor activity, nausea, abdominal pain, vomiting, diarrhea, priapism, reduction of diurea. Interaction:Do not combine with drugs affecting on onbuilding, incl. antidepressants. Method of use and dose:Inside (while eating, drinking a glass of water), 5-10 mg 1-3 times a day for 3-10 weeks (no more). If necessary, the course is repeated. Precautions:It is impossible to apply with diseases accompanied by the risk of sudden drop in the blood pressure and development of tachycardia.
Activity (MNN) Bismuth Subnithrate (Bismuth Subnitrate) Restrictions on use:Hypersensitivity, kidney oni insufficiency. Side effects:Head oni pain, edema and gums, vesiculas and pigmentation on language, nausea, vomiting, methemoglobinemia. Interaction:Compatible with cholinolitic, antispasmodic agents, often used for pressing stomach ulcer and two onbedtime. With simultaneous admission of tetracycline, the formation of non-playing complexes is possible. Method of use and dose:In dermatology - ongunny, in the form of ointments and powder (5-10%). In the pathology of the gastrointestinal tract - inward, 15-30 minutes before meals (drinking sufficient water), adults - 0.25-0.5 g 4-6 times a day, children - 0.1-0.5 g 3 -4 times a day.
Dzardact Broncho
in Flako onx 60 ml (with doses. spoon); In a pack of cardboard 1 bottle. Method of use and dose:Inside Blinding before use. Adults and children over 12 years old - 20 ml (4 h. Suki) 3 times a day. Children 6-12 years old - 10 ml (2 h. Such) 2-3 times a day.
Included in the preparations ATH:R.03.C.A.02 Ephedrine Pharmacodynamics:Sympathomimetics (indirect adrenomimetics), alkaloid, obtained from various types of ephedra (Ephedra L.) of the ephedric family (Ephedraceae). contained in plants is a leaving isomer. It is synthetically obtained by a racemate, inferior to the activity of the leaving isomer. After administration of ephedrine, the α- and β-adrenoreceptors are excited: acting on varicose thickening of efferent adrenergic fibers, contributes to the release of the norepinephrine mediator into the synaptic slot. In addition, it has a weak stimulating effect directly on the adrenoreceptors. Stimulates the activity of the heart (increases the frequency and force of abbreviations), facilitates the atrioventricular conductivity, increases the blood pressure, causes the bronchhalytic effect, suppresses the intestinal peristalsis, expands the pupil (without affecting accommodation and intraocular pressure), increases the skeletal muscle tone, causes hyperglycemia. In contrast to epinephrine, the effect of ephedrine develops slowly, but continues longer. When re-introducing ephedrine with a small interval (in 10-30 minutes), its pressing effect is rapidly decreasing - tachyphylaxia arises (rapid addiction) associated with a progressive decrease in norepreenaline reserves in varicose thickening. The ephedrine stimulates the CNS, according to a psychostimulating action close to the fechenine. The activity of Mao and Catechol-o-methyltransferase is inhibits. Pharmacokinetics:Absorption is good. Biotransformation in the liver (insignificant). The half-life is 3-6 h (shortening when urine acidification). Elimination by the kidneys, mainly unchanged (amplification of urine acidification). Indications:Arterial hypotension in surgical operations (especially with spinal anesthesia), injury, blood loss, infectious diseases. Bronchial asthma and other obstructive diseases of the respiratory tract, vasomotor and allergic rhinitis, sinusitis (for narrowing the vessels of the nasal mucosa), serum disease, urticaria and other allergic conditions. Narcolepsy, Enapers (as a result of stimulating influence on the central nervous system, sleep becomes less deep, waking up waking up when urinary calls appear to urination), myasthenia. In ophthalmologic practice: to expand the pupil with a diagnostic purpose. V.F90-F98.F98.0. Enurrena inorganic nature VI.G70-G73.G70.2. Congenital or acquired myasthenia IX.I95-I99.I95 hypotension X.J30-J39.J30.3. Other allergy rhinitis X.J30-J39.J30.1. Allergic rhinitis caused by pollen plants X.J30-J39.J30.0. Vasomotor rhinitis X.J30-J39.J32. Chronic sinusitis X.j00-j06.j01 sharp sinusitis X.j40-J47.j44 Other chronic obstructive pulmonary disease X.j40-J47.j45 asthma XII.L50-L54.l50 Urticaria Xxi.z00-z13.z01.0. Survey eye and view XIX.T80-T88.T80.6. Other serum reactions Contraindications:Uncontrolled arterial hypertension and tachycardia, hypertrophic obstructive cardiomyopathy, insomnia, pomechromocytoma, ventricular fibrillation. Carefully:Caution to apply in metabolic acidosis, hyperkapinia, hypoxia, flickering arrhythmia, clotted glaucoma, pulmonary hypertension, hypovolemia, myocardial infarction, occlusal diseases of the vessels (including history): arterial embolism, atherosclerosis, burgher disease, frostbite, diabetic endarteritis, disease Reino; diseases of the cardiovascular system (including angina, tachyarhythmia, ventricular arrhythmia, coronary insufficiency, arterial hypertension), diabetes mellitus, thyrotoxicosis, benign prostate hyperplasia, while using inhalation anesthesia. Pregnancy and lactation:The use of ephedrine during pregnancy and during lactation (breastfeeding) is possible only if the potential benefits for the mother exceed the possible risk to a fetus or baby. Method of use and dose:Adults subcutaneously, intramuscularly or intravenously injected at 20-50 mg; Inside - 25-50 mg 2-3 times a day. For local application, the dosing mode is individual. Maximum doses: for adults when taking inside and subcutaneously, a single dose - 50 mg, a daily dose - 150 mg. Side effects:From side CNS and peripheral nervous system: Headache, sleep disorder, weakness, nervousness, motor anxiety, dizziness, cramps, muscle spasms, tremor, numbers or feet, drowsiness, expansion of pupils, fuzziness of visual perception; When used in high doses - hallucinations, a change in mood or psyche. From side of cardio-vascular system:angina, bradycardia or tachycardia, heartbeat, increase or decreased blood pressure, ventricular arrhythmia, feeling of discomfort or pain in the chest, hemorrhage, hyperemia of the face, narrowing peripheral vessels. From side digestive system:nausea, vomiting, dryness or irritation of the oral cavity or pharynx (with parenteral use), loss of appetite, heartburn. From side urinary system: Difficult and painful urination. Others:increased sweating, pallor of skin, allergic reactions, shortness of breath or difficulty breathing, chills, hyperthermia; Local reactions - pain or burning in place of intramuscular injection. Overdose:Hypertension, arrhythmias, transient bradycardia with transition to tachycardia, myocardial infarction, pulmonary swelling, renal failure, metabolic acidosis, dysnae, headache, vomiting, unusual pallor, cooling skin. Treatment is symptomatic. Interaction:The ephedrine weakens the effect of opioid analgesics and other means of depressing CNS. With simultaneous use with non-selective beta-adrenoblockers and nitrates - the weakening of the therapeutic effect (the blockade of β-adrenoreceptors can lead to the prevalence of alpha adrenergic activity with the risk of arterial hypertension and pronounced bradycardia with the possible development of the blockade of the heart; the blockade of β-adrenoreceptors also hampers Beta 2 -Adrenergic bronighting effect). Means linked to the urine (including antacids containing calcium and magnesium ions, carbonic henhydrase inhibitors, citrates,) increase the semi-alone ephedrine and the risk of intoxication. With simultaneous use with heart glycosides, quinidine, tricyclic antidepressants, dopamine, means for inhalation anesthesia (chloroform, enfluraura, methoxyfluran, trichloroethylene) increases the risk of developing heavy ventricular arrhythmias; with other sympathomimetics - enhancing the severity of side effects from the cardiovascular system; With antihypertensive means (including with sympatholithic, diuretics, alkaloids Rauolfia) - reduction of the hypotensive effect. Simultaneous use with bronchodiolitic means beta-adrenomimetics is possible additional excessive stimulation of the CNS, which can cause increased excitability, irritability, insomnia, convulsions, arrhythmias. With simultaneous use with reserparies and inhibitors of MAO (including,), headache, heart rate disorders, vomiting, sudden and pronounced increase in blood pressure, hyperpyrical crisis are possible; with phenytino - a sudden decrease in blood pressure and bradycardia (depends on the dose and the rate of administration); With thyroid hormone preparations - mutual gain of action. Increases metabolic clearance with glucocorticosteroids, ACTH with prolonged use (their doses correction may be required). , Ergotamine, increase the vasoconstrictor effect and risk of ischemia and gangrene. Legodopa increases the risk of arrhythmia development (reduction in the dose of sympathomimet). Enhances the stimulating effect on the CNS and the risk of toxic phenomena of xanthines (including aminoophylline, theophylline, caffeine). Cocaine enhances stimulating effect on the CNS and the cardiovascular system. Special instructions:In order to avoid disorders of the night sleep, it should not be used and containing its preparations at the end of the day and before bedtime. It is impractical to apply for a long time. Due to the stimulating influence on the central nervous system, there may be a means of abuse. Instructions
CompositionThe composition of one ampoule is contained ephedrine Hydrochloride 50 mg per 1 ml. As part of 1, the ephedrine ARSAN tablet contains 50 mg of ephedrine. Form releaseSolution for injection and tablet. pharmachologic effectEphedrine - What is it? it from andmpatomimetic . Pharmacodynamics and pharmacokineticsBasic substance - ephedrine hydrochloride. What is it and how is it? The active ingredient stimulates Beta and Alpha's adrenoreceptors. Under the influence of the drug there is a selection norepinephrina In the lumen of the synaptic gap. The medication affects varicose thickening in adrenergic, efferent fibers. Ephedrine is able to provide a low-rise stimulating effect on adrenoreceptors. The drug causes psychostimulating, bright and vasoconstrictor actions on the body. Preparation improves atrioventricular conduction , increases heart rate, IOC, heart rate, increases systemic levels Both OPS, inhibits intestinal peristalsis, increases blood sugar levels, increases the tone of skeletal muscles. The active ingredient expands the pupil without affecting and accommodation . According to the psychostimulating effect, the medication is close to . The drug is able to inhibit the activity of catecholamino-0-methyltransferase, monoaminoxidases. The medication stimulates alpha-adrenoreceptors in the blood vessels of the skin, narrowing extended vessels, which leads to a decrease in their increased permeability. This mechanism explains the decrease in edema severity at. When taking ephedrine inside the therapeutic effect develops after 15-60 minutes, it lasts about 5 hours. With intramuscular administration, the effect is registered after 10-20 minutes, it lasts about an hour. Pressorh effect The drug during re-administration after 10-30 minutes is rapidly decreasing, a tachyphylaxcia is developing, caused by a decrease in norepinephrine reserves in varicose thickening. Indications for useThe cardiovascular system: discomfort and sternum pain ventricular , drop blood pressure, heartbeat, tachycardia either bradycardia, angina, hyperemia of skin cover, unusual hemorrhages. Excessive amount of drug with myocardial infarction can cause strengthening and progression ischemia Due to improving the need of myocardial tissues in oxygen. Correction of hypovolemia is carried out before conducting therapy. The administration of ephedrine is not a replacement of saline solutions, blood-absorbing liquids, plasma, blood. Unacceptably long-term treatment with Ephedrine. During the reinforcement anesthesia, the drug can provoke the increase in the fetal heartbeat. The medication may cause a resistant hypertension with preparations with preparations that enhance generic activities, when adding topless drugs during the delivery. Unacceptable use of an opaque solution. The residues of the solution after infusion are being destroyed. Earlier, ephedrine was taken inside with Miasthenia therapy, Enurrawa. With joint admission of monoaminoxidase inhibitors, there is an increase in the pressing effect of sympathomimetics, which causes vomiting, headaches, arrhythmia, risk risk hypertensive crisis . There are many methods for the synthesis of this alkaloid. The medication is described in Wikipedia. There is also an appropriate pharmacopoeia article. The combination of ephedrine + caffeine + is used in bodybuilding and fitness for "drying". However, we do not advise you to use it, it can be dangerous for your health. AnalogsCoincidences on the ATX 4 level code:Analogues include preparations containing the same active substance : , , Ephedrine hydrochloride. You can buy drug data only by recipe, as they are potent. Also use them followed by the doctor's control. |
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