• Latin name:ENALAPRIL
• ATH code:C09AA02.
• Active substance:Enalapril
• Manufacturer:Hexal AG (Germany)

Composition

The tablet includes a valid enalapril in the amount of 5, 10, 20 mg, as well as auxiliary substances: gelatin, lactose monohydrate, magnesium stearate, magnesium carbonate and crospovidon.

Form release

Tablets for 10 pieces in a blister, 2 blisters in a pack.

Available in various pharmaceutical companies, as a result of which the company name is added to the title of the active substance in the title of the drug, for example: Enalapril Health.

pharmachologic effect

The medication reduces pressure, expands the clearance of blood vessels, has cardioprotective and sodiumuretic act. The drug belongs to the group of angiotensin surgery enzyme inhibitors.

Pharmacological Group: ACF inhibitors.

Pharmacodynamics and pharmacokinetics

According to the annotation, the mechanism of action lies in the inhibition of an angiotensification enzyme (ACE) by Enalapril, from which the decrease in the biosynthesis of angiothepzine II leads to vasodilation, the production of PHA2 and bradykinin, which are powerful vessels.

In patients with heart failure with long-term reception (6 months and more), an increase in portability of physical exertion is noted, the size of the heart decreases, the amount of lethal exodes decreases. Under the influence of the drug, a small circle of blood circulation is unloaded, the pressure in the pulmonary capillaries is reduced, the OPS is reduced, increases Cardiac ejection (CSS does not increase at the same time).

The absorption of the drug Enalapril reaches 60% independence from the reception and availability of food in the gastrointestinal tract. The maximum concentration of the active substance of enalaprilalate is observed after 1 h after applied. In the liver, biotransformed to enalaprilata. . It easily passes through the placenta, histohematic barriers. Excreted by the kidneys. The hypotensive effect is recorded after 1 h after the introduction of drugs lasts day. To achieve optimal results, hell requires several weeks of regular admission of enalapril.

Indications for the use of Enalapril

What is the tablets Enalapril?

Indications for the use of enalapril are as follows :, Reino disease, heart failure, symptomatic arterial hypertension, diabetic Nephropathy , sclerodermia secondary hyperldosteronism . Enalapril is prescribed as part of complex therapy in the treatment of voltage, CPN. Apply tablets from pressure elevated.

Contraindications

Hypersensitivity to ACE inhibitors, renal arterial stenosis, azotemia , hyperaldosteroneism, hypercalemia , impaired kidney function, (hereditary character), stenosis of the mouth of aorta, children's age. Enalapril is not prescribed.

Side effects

The drug is as follows side effects: Increased fatigue, dizziness, headache, cramps, nervousness, insomnia, glossitis, ears, nausea, orthostatic hypotension, heartbeat, dyspeptic disorders, liver disorders, kidney, hypercalemia, sweet Qincke , neutropenia, raising the level of bilirubin in the blood, hair loss, pain in the heart area, increasing the concentration of hepatic transaminases.

Enalapril Tablets, Application Instructions (Method and Dosage)

The medicine is taken inside. The initial dosage is 5 mg per day, the drug is accepted 1 time per day. In the pathology of the renal system, the reception of diuretic drugs is reduced to 2.5 mg. To achieve the effect, depending on the individual features, the dose of the drug can be increased to 10-40 mg per day (you can break up 2 receptions).

Instructions for use Enalapril Hexal

The drug is used regardless of food intake.

For arterial hypertension 5 mg of Enalapril Maleate in the morning should be taken. Supporting dose is 10 mg. You should not take more than 40 mg of the drug per day.

In chronic heart failure, 2, 5 mg of medication in the morning is taken. Supporting dose is 5-10 mg. You should not take more than 20 mg of the drug per day.

With the dysfunction of the left ventricle, 2.5 mg is taken twice a day. Supporting dose is 10 mg twice a day.

How to take in disabilities of the kidneys? This situation consumes 2.5 mg per day. Supporting dose is usually 5-10 mg. Maximum dose - 20 mg per day.

Instructions for use of Enalapril Acry

Anytime. First take 2.5-5 mg every 24 hours. Supporting dose is 10-20 mg every 24 hours. Maximum dose - 40 mg per 1-2 reception.

Instructions for Enalapril FPO

Similar to the method of dosage of the previous preparation.

Reception scheme Enalapril N

1-2 tablets once every 24 hours, regardless of food intake.

Overdose

Excessive fall arterial pressure, myocardial infarction , ONMK, thromboembolic complications as a consequence of a sharp decline in blood pressure. Treatment: B / in the introduction of NaCl (isotonic solution). No specific antidote.

Interaction

The absorption of the drug does not depend on the meal. With simultaneous reception with Beta-Adrenoreceptor blockers, nitrates , methyldop, calcium antagonists, Enalapril hydralazines potentiate a hypotensive effect. Cimetidine Increases T1 / 2 drugs. NSAID Increase nephrotoxicity, reduce the effectiveness of enalapril. Potassium preparations and potassium diuretics when taking LS lead to hypercalemia. Enalapril reduces half-life teofillin , reduces lithium clearance. HP does not interact with Heart glycosides .

Terms of sale

Requires a recipe.

Storage conditions

At temperatures up to 25 degrees Celsius in a dry, inaccessible place for children.

Shelf life

Not more than 3 years.

special instructions

In the first hours of administration, Enalapril can lead to a pronounced decrease in blood pressure. This is especially manifested in individuals for the first time hosting a hypotensive drug, in patients with CPR, strongly pronounced heart failure, hypovolemia, hyponatremia. For the prevention of a sharp decline in Hell 2-3 days before the reception of Enalapril cancels the baking diet. With the development of angioedema edema on the face, the neck is necessary to cancel the reception of the LS, assign antihistamines. In severe cases, intubation, tracheotomy. It is not recommended to simultaneously assign potassium-saving diuretics. It is necessary to regularly monitor hemostasis. Enalapril does not appoint women planning pregnancy.

The medicine is registered WHO for the information of the Director of Vidal.

It is often used with hydrochlorostiazide as a combined means.

Recipe on Latin: Tab. ENALAPRILI 0,01

MNN: Enalapril (ENALAPRIL).

Analogs of Enalapril

Lysinopril or Enalapril - What is better?

Lysinopol on the basis of research more effectively reduces blood pressure, as well as a larger period of time. Both drug is transferred approximately equally.

Enap and Enalapril - What is the difference?

In essence, the drugs are no different, as they have the same active substance. However, the price of Anapa is much higher than the analogue.

Enalapril and Enalapril Hexal

The drug is manufactured by Hexal, from which it has an appropriate addition in the title.

Reviews of Enalaprile

Reviews of doctors are reduced to the fact that it is a very effective, wide, high-quality drug for blocking ACE. Really reduces pressure, however, has a number of contraindications and side effects, such as cough.

Reviews of Enalapril Hxhal on the forums also have a total positive color. The tool effectively reduces blood pressure, is inexpensive, but it has a frequent side effect.

The price of Enalapril, where to buy

Drug is sold for 15-20 rubles.

How much is an Enalapril 10 mg? About 15 rubles.

The price of Enalapril Hexal is 85 rubles per pack of 20 pieces of 20 mg.

• Internet pharmacies of RussiaRussia
• Internet pharmacies of UkraineUkraine
• Internet pharmacies in KazakhstanKazakhstan

Healthcare

Enalapril-Teva Tab. 5mg N20

Enalapril Tablets 5mg №20 Pharma PharinoLLC "Izvarino Pharma"

Enalapril Tablets 10mg No. 20 OrganicJSC Organiza

Enalapril Tab. 20mg №20JSC Obolensk Farm. company

Enalapril Hexal Tab. 10mg N20Salutas Pharma Gmbh.

Pharmacy dialogue

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Enalapril (tab. 20mg №20 (alum. Foil PVC))

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Enalapril-Hemofarm 10 mg N20 TableHemofarm-Russia

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Enalapril-hexal 10 mg №20 TableSalutas Pharma GmbH

Enalapril-hexal 5 mg №20 TableSalutas Pharma GmbH.

Enalapril-hexal 20 mg №20 TableSalutas Pharma GmbH

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If there are problems with blood pressure, many receive recommendations from the attending doctors to take the drug "Enalapril" (pills). What helps to get rid of this medicine? From the consequences of the disease (that is, directly from the increase in blood pressure), or it acts in several directions, restoring the normal activity of the cardiovascular system, as a result of which hell comes to normal? To understand how tablets act from Pressure "Enalapril", it is worth familiar with the official instructions for the use of this medication. In addition, we consider a number of analogues of this drug on the active substance and the effect being rendered.

Description of the drug, release form, storage features and leave of pharmacies

Pellets from pressure "Enalapril » Many pharmaceutical companies are produced throughout the world. The main active substance of this drug It is Enalapril Maleat, who in its group affiliation refers to the ACE blockers. Currently, there are tablets with an existing substance of 5, 10 and 20 mg. Due to the fact that the drug from the pressure "Enalapril" directly affects the functioning of the SCC and a number of other systems in the body, his vacation from pharmacies is carried out according to the doctor's prescription.

The deadlines for the implementation and use of this drug are limited to 3 years since its production. At the same time, the tablets do not lose therapeutic properties subject to storage rules. Manufacturers recommend holding a medicine in a dry, direct sunlight location, at a temperature of at least 15 and not more than 25 degrees.

Analogues of "Enalapril" have the same properties, therefore, recommendations applicable to the drug can be observed when they are stored.

Pharmacodynamics of the medicinal product

Enalapril Maleat (active substance of tablets) itself does not affect the human processes in the body. The fact is that this compound is considered a peculiar "prodrug", which, as a result of the few hydrolysis reactions, forms a completely new substance - Enalaprilat.

It is precisely it acts in oppressively on active ACE, which provokes a significant decrease in the amount of aldosterone in the human body. In a word, the action of "Enalapril" is to reduce the blood pressure (both diastolic and systolic) and reduce the load on the heart muscle (myocardium).

As a result of long observations, it was possible to find out that, despite the decrease in blood pressure, after receiving the drug "Enalapril" in patients, there was no insufficient level of blood circulation in the brain. In addition, the reception of the tablets contributed to the strengthening of the renal and coronary blood flow.

Long-term use of the drug showed high efficacy with respect to hypertrophied tissues localized in the left ventricle of the heart muscle, which contributed to the prevention of the progress of heart failure. In addition, the therapy "Enalapril" for 6 months improved the condition of patients in dilatation of the left ventricle and the disturbed blood circulation in myocardium, which arose as a result of ischemia.

The active ingredient of the drug is found in the blood plasma after 1 hour after receiving the tablets and reaches the maximum after 4-6 hours. The hypotensive effect lasts up to 24 hours.

Same pharmacological properties The analogues of "Enalapril" on the active substance are also.

Pharmacokinetics drug

As mentioned above, the absorption of the active substance of the drug occurs quite quickly. Total about 60% of Enalapril Maleate is absorbed, while almost the entire volume comes into contact with plasma proteins. Specialists draw consumer attention to the fact that the connection absorption does not depend on the feeding.

The high degree of penetration of enalapril through GGB barriers is due to the molecular structure of the active substance. It is also capable of overcome placental barriers and is found in the tissues of the chest glands and milk in nursing women.

The removal of the drug is carried out mainly by the kidneys (60%). At the same time, about 20% is removed, and 40% in the form of a metabolite. The remains of the active substance extend through the intestines, while the relation of enalapril / enalaprilalate has indicators of 6-8% / 25-27%.

Indications and Contraindications for use

An indication of the use of the drug "Enalapril" is a persistent increase in blood pressure caused by diseases such as sclerodermia and hsn. In addition, the drug is very often used in prophylactic therapy in patients with diagnosed coronary ischemia, LV dysfunction (including asymptomatic). These are the drug "Enalapril" of indications for use, but in no case is not recommended to engage in self-medication. Only a specialist can make a faithful treatment regimen and determine the dosage.

During the survey, the doctor can also establish the presence or absence of possible contraindications. These include the following diseases and violations of the functioning of the organs:

1. The increased level of sensitivity to the active substance of the drug (analogues "Enalapril" is also necessary to cancel, since in most cases there are similarity with this drug composition).
2. Pregnancy, lactation and children up to 18 years old.
3. Previously chase angioedema edema during treatment with preparations from the ACE inhibitors group.
4. Failure brain circulationas well as other cerebrovascular diseases.
5. Brain-forming disorders.
6. Kidney disease, including (bilateral or unilateral), renal failure, the presence of a transplanted organ.
7. Liver diseases.
8. Diseases of the gastrointestinal tract accompanied by diarrhea and vomiting.
9. Sclerodermia and other autoimmune diseases affecting connective tissues.
10. Disorders of metabolic processes in the body, including hypercalemia.
11. Diabetes.

Reception "Enalapril" in all situations described above must be canceled, or therapy is carried out under the constant monitoring of specialists.

Medication "Enalapril": a list of side effects

Despite the greater benefit of the drug, with its admission, patients may have a variety of side effects that affect almost all organ systems. Information about unwanted phenomena is contained in the table below.

First of all, these phenomena are provoked by the direct influence on the body of the main active substance of the drug "Enalapril". Analogs (instructions for use in them contains detailed information on this issue) can also cause such violations. Patient and his attending doctor is important in time to notice signs of appearance side EffectsSince their ignoring can lead to serious disorders in the functioning of the body.

How to take Tablets "Enalapril": Methods and dosage

For stabilization hell specialists recommend long use medicinal product (including its analogues, for example, the drug "Enalapril Hexal"). At the initial stage of treating arterial hypertension, it is recommended to take the drug at a dose of 5 mg per day. With a systematic increase in pressure during two-week therapy, the dosage increases by 5 mg. It is worth noting that the first 2-3 hours after the start of treatment the patient should be under the supervision of the doctor. It helps to identify side effects at the very beginning of their development. The maximum dose of the drug should not exceed 40 mg per day, but even the use of such a quantity of medication is possible only under the condition of absolutely necessary and satisfactory tolerance of the medication.

After 2-3 weeks after the start of monotherapy, the drug "Enalapril" patients are transferred to the supporting drug treatment regimen. During this period, the daily dose of medication is 10-40 mg. Drink tablets need 1-2 times a day. Recommended during treatment regularly measure blood pressure.

The above recommendations are applicable to those patients who do not suffer such accompanying diseases as hyponatremia and in what doses should be taken to them? As a rule, it depends on the individual characteristics of the patient and the degree of development of diseases. The initial dose in any case can be calculated only by the attending physician.

The duration of the drug reception depends on several factors, which include the state of the patient and the results of laboratory research. Specialists note that the sharp abolition of the drug can lead to negative consequences. Therefore, even with an excessive decrease in blood pressure on the background of the introduction of medication "Enalapril", it is necessary to gradually reduce the dosage.

Symptoms and overdose treatment with drug

So, we reviewed the basic characteristics of the "Enalapril" drug (tablets): from which they help and what can lead their reception in the end. It's time to go to the discussion of such a question as an overdose by this drug. Often, patients tend to take big doses of drugs in the hope faster to get rid of unpleasant symptoms. In the event that this happens with the cure for the "Enalapril" man, the consequences can be very serious. Against the background of the decline in blood pressure in patients, a collapse may occur, which often leads to myocardial infarction or serious violations of cerebral circulation.

As a rule, the first symptoms of overdose are the loss of consciousness, the state of the stupor or the appearance of convulsion. Other signs of the lesion of the brain circulation system and heart activities can be observed: pallor skin Pokrov, severe headache, sore pain.

Treatment of the patient with an overdose of the drug "Enalapril" is symptomatic. With a light of poisoning, the reception is shown salt solution And washing the stomach. In more severe cases it may be necessary intravenous administration Improvers and plasma substitutes, as well as hemodialysis.

Medicinal interaction

Tablets "Enalapril" are capable of acting atypically with simultaneous reception along with other medicines. Non-steroidal anti-inflammatory drugs ("ibuprofine", etc.) and estrogen-containing drugs significantly reduce its hypotensive effect. Adrenoblays, nitrate-containing drugs, anesthetics and ethanol enhance the effect of Media "Enalapril". Diuretic preparations taken jointly with pills to reduce pressure can cause hypercalemia development. With extreme caution, it should be treated with medications from the group of immunosuppressants, since they, with joint admission with enalapril medications, significantly enhance its hematotoxicity.

Enalapril refers to the group synthetic preparationsdesigned to reduce blood pressure. He has long been known for hypertensive and enjoys well-deserved recognition.

This medicine requires careful use.

Therefore, it cannot be taken without a consultation with the doctor. Also importantly familiarize yourself with the provisions of the instructions for use.

Features of the form and composition

Enalapril is produced in the form of tablets with an active substance by enalapril 5, 10 and 20 mg in each tablet.

Auxiliary components are presented:

• lactose monohydrate,
• magnesium carbonate,
• gelatin
• magnesium stearate,
• crosspovidone.

The number of tablets in the cell contour package - 20 or 30.

The instructions noted that the drug packaging should be stored in conditions protected from moisture and having a temperature of from 15 to 25 ° C. Children should not have access to the medicine. The term of its shelf life is three years. After this time, the tool cannot be used.

Therapeutic properties

Enalapril has a hypotensive effect (gradually reduces blood pressure).

To others medical properties The drug includes:

• expands vessels,
• reduces vessel resistance on the periphery,
• weakens the load on myocardium,
• lowers pressure in the zone of the small circle of blood circulation,
• increases the ability to withstand physical exercise,
• reduces deformations in the left ventricle,
• improves the picture of glomerular hemodynamics in the kidneys (preventing diabetic nephropathy).

The drug contributes to the expansion of the arteries to more than veins, without the reflex jump readings of the pulse. The maximum result is formed after 6-8 hours from the moment of reception and is kept during the day.

A steady therapeutic effect is formed in a few weeks of therapy. We can read about the results of treatment in the feedback placed at the end of the text.

About 60% of the amount of adopted dose is subjected to rapid suction from the gastrointestinal tract. Metabolism of medication occurs in the liver. It is excreted in the bulk of the kidneys, as well as the intestines.

Video

Opinion of doctors about the drug Look in the video:

Indications for use

According to the instructions, Enalapril is shown at:

• arterial hypertension at any stage (including renovascular),
• left ventricle dysfunction
• diabetic nephropathy,
• cardiac insufficiency in chronic form (as an element of complex treatment).

Contraindications

In the circle of contraindications of the drug entered:

• angioedema edema due to use aPF inhibitors,
• swelling of the hereditary nature,
• porphyry
• disorder of the kidney and stenosis of their arteries,
• azotemia
• hypercalemia
• after kidney transplant
• pregnancy and feeding states
• children's age less than 18 years (there are no data on safety and performance),
• hypersensitivity to enalapril and other ACE inhibitors.

The states in which increased caution is necessary:

• systemic diseases connective tissue,
• cerebrovascular diseases
• renal and liver failure,
• stay on hemodialysis,
• diabetes (due to possible hypercalemia),
• compliance with a volatile diet,
• parallel treatment with immunosuppressants and saluretics,
• elderly age (from 65 years).

Side effects

On the possible negative consequences of the reception of Enalapril, the instruction considers:

• too strong decrease in blood pressure,
• progress
• orthostatic collapse,
• dizziness with headache
• insomnia
• confused
• weakness,
• anxiety,
• depression
• excessive fatigue
• dyspeptic disorders
• dry cough,
• bronchospasm
• intestinal obstruction
• itching I. skin rash,
• stomatitis,
• disorder of the kidneys
• tides
• reducing libido.

Attention! What not to forget during treatment!

The therapeutic effect of the medication will be maximal if to keep in mind the factors:

1. Before treatment and in the process of reception, it is necessary to resort to periodic control of blood pressure, hemoglobin, urea and other blood indicators, protein in urine.
2. If high-permeable dialysis membranes are used, the danger increases anaphylactic reaction. In those days when dialysis is not carried out, the dosage correction must be performed depending on the pressure.
3. Patients with vascular and cardiac problems need the treatment in careful observation.
4. With a sudden abolition of the drug, the "cancellation" syndrome is not marked (sharp jump pressure).
5. Arterial hypertension in the patient may in the process of treatment lead to an increase in creatinine and urea in the blood serum. These patients require the control of kidney function, especially in the first weeks of treatment. It is possible to reduce the dose.
6. If the inspection of the work of the parathyroid glands is to be examined, the medicine must be canceled.
7. From alcohol, the hypotensive effect of the drug is enhanced.
8. Before any surgical operation (including in dentistry) you need to warn your doctor about the treatment of ACE inhibitors.
9. Before the constant dose of medication is calculated, at the beginning of the reception, it is necessary to refrain from driving transport and work requiring concentrated attention and rapid reactions. In this period of treatment, dizziness may occur.

On the consequences of drug interaction

It is important to know about the combination of enalapril with other drugs, which indicates the instructions:

1. Connection with anti-inflammatory nonteroid drugs It can reduce the hypotensive effect. The same result occurs when eating food with sodium chloride in large quantities.
2. Adding to the treatment of potassium-saving diuretics (amyloida, spironolactone) is dangerous hyperkalemia.
3. The combination with lithium salts is fraught with a slowdown in lithium.
4. The effectiveness of the medication may decrease from the simultaneous reception of painkillers and antipyretic agents.
5. Enalapril reduces the effect of medicines with theophylline.
6. The hypotensive effect of the drug amplifies diuretics, nitrates, beta-adrenoblays, prazosin, methyldop, hydralazine.
7. From immunosuppressants, cytostatics, allopurinol amplifies hematotoxicity.

Various aspects of practical use

General application scheme

Enalapril is prescribed inside, regardless of food. The primary dose is determined depending on the level of the disease. It is usually equal to a one-time reception per day from 2.5 to 5 mg. The initial dose reception should be under medical supervision for 2-3 hours, until the pressure stabilizes.

If necessary, motherwise dose It increases to 20 mg and can be distributed in two receptions per day. On the usual supporting dosage transition in two or three weeks. It is a day from 10 to 20 mg. The maximum amount of medication is 40 mg per day (with its normal portability).

It is used in domestic medicine for a long time, and is still in demand among patients suffering from increased blood pressure (AD).

The effect of this drug is reduced to a decrease in the effect of angiotensin on the vascular channel and to the release of aldosterone from adrenal glands, which ultimately leads to a resistant antihypertensive effect. How to take Enalapril, and with what medications it can be combined - we'll figure it out.

The dosage of the drug, as well as the amount of its receptions per day, is calculated based on the individual characteristics of the patient, and can only be determined by the attending physician.

Nevertheless, there are generally accepted standards, how to take enalapril high pressureAnd it is quite possible to rely without prior consultation with a specialist:

• in arterial hypertension, the daily dose of the drug should be 10 mg (1 tablet 1 time per day);
• with heart failure - 2.5 mg (¼ tablets 1 time per day).

In the absence of a tangible effect, the dosage can be increased, but only within 40 mg per day (excess of this limit is fraught with serious consequences for health, up to the onset of death).

How many times a day?

As far as Enalapril is effective, and how many times a day it will receive this drug, only a qualified cardiologist can determine with accuracy, but in most cases, the reception of this medicine is limited to 1 tablet per day.

If we are talking about monotherapy (when the patient is written only, without auxiliary drugs), then the daily dose in the first phases of treatment is 5 mg, and at later 10-20 mg. Comprehensive therapy, in turn, implies the reception of 2.5 mg of enalapril per day at the beginning of treatment, and the subsequent increase in the daily dose to 5-15 mg with an insufficient hypotensive effect.

Before eating or after?

For all who are interested in how to take enalapril (before eating or after), it is important to know that clear instructions in official instruction No matter what. The fact is that the unique features of the drug make it possible to take it to the same success, during, or after eating, at the discretion of the patient.

The speed of the occurrence of a positive effect is almost does not depend on that on an empty stomach, you accepted Enalapril, or after meals.

In the morning or evening?

Instructions in the instructions about how to take enalapril - in the morning or in the evening, are also very extensive. However, although the effectiveness of the drug does not depend on the time of its reception, for reasons of expediency, it is best to do this in the morning (in this way you can hold hell in the norm throughout the subsequent day).

For example, enalapril tablets containing 5 mg of the active substance are usually discharged with light shapes of heart failure and arterial hypertension, and are accepted either 1 time per day (in the morning), or 2 times a day (in the morning and evening), depending on the patient's condition.

In acute heart failure and severe arterial hypertension to receive, as a rule, tablets with 10 mg of the active substance are prescribed, which are also recommended to use in the morning (once), or in the morning and in the evening (twice). In separate cases, the two-time techniques of Enalapril are combined - instead of one tablet in the morning and one evening they use two in the middle of the day. It all depends here on how the drug acts on your body, and the dosage should be adjusted on the basis of your well-being.

Positive action of tablets from increased pressure

Dissat or drink water?

Many patients are interested in the question: "Enalapril - how to take (dissipate or drink water)?". It is important to remember that with regular use of the tablet, you need to be taken without chewing, drinking with a minimum amount of water. This method is most optimal for long-term treatment courses when the drug is applied daily.

If we talk about those cases when you only have the need to quickly shoot down from time to time, it is best to use - the so-called "enalapril short action". It should be dissolved by putting under the tongue. The optimal dose is 25 mg (maximum - 50 mg) per day.

How to take at the same time with other medicines?

Enalapril is often prescribed to the reception in a complex with other drugs, which, together, significantly improve the picture of the disease and effectively cope with arterial hypertension. Some of them are worth telling more.

Many cardiologists write out their patients amlodipine and Enalapril. Is it possible to take these medicines at the same time?

Recent studies show that it is possible, and in tandem these drugs adversely smooth the magnitude and speed of the morning lifting of blood pressure, which is rarely observed during their separate reception. In addition, they significantly reduce the risks of damage to the so-called target organs (heart, brain, kidney, etc.), suffering from hypertension in the first place. Thus, Enalapril and Amlodipine can be adopted together, but previously this question should still be clarified by his attending physician.

Enalapril is also often used in a pair with bisoprolol, which refers to the category of beta adrenoblockers. Such a combination requires compulsory dose titration, since with imperative use, these drugs can reduce hell to a critical level, up to a critical condition and fatal outcome. Therefore, all those who are interested in the question: "Bisoprolol and Enalapril - is it possible to take together?" Should be sure to consult on this card with a cardiologist.

Indapamide

As for diuretics, Most often, an indapamide is prescribed together with ENalapril, which is effectively struggling with the swelling caused by heart failure and arterial hypertension. Is it possible to take enalapril with Indapamide without the knowledge of the attending physician? Unambiguously - no, since the second significantly enhances the hypotensive effect of the first, and can lead to a critical fall of blood pressure.

Euticox

Euticox and Enalapril - how to take? Hormonal drug To combat the pitipofing of the thyroid gland - Eutirox - to use simultaneously with the enalapril, it is necessary very carefully, only after preliminary diagnostics and testing. As a rule, the daily dose of the first when co-use is up to 120 mg per day, and the second is up to 10 mg per day.

Vipotropyl (piracetam + vinpocetin)

Nootropic drug Vinopotropyl (which includes piracetam and vinpocetin) and can Enalapril be taken together together? This question is given by many patients suffering from violations of cerebral circulation against the background of arterial hypertension.

Vinopotropyl really reduces systemic blood pressure, but at a slight degree, and its effect is mainly reduced to the relaxation of cerebral vessels and improved blood microcirculation in brain tissues. You can take it together with Enalapril, but only with a clear dosage compliance.

Cardiomagnet

Is it possible to take enalapril and cardiomagnet at the same time? This is quite appropriate in cases where the patient against the background of arterial hypertension suffers from atherosclerotic damage to the vessels. Nonteroid Antiagrageant Cardiomagnet prevents the development of thrombosis and acute heart failure, but in a complex with Enalapril can be appointed only after a thorough examination, on the recommendation of the attending physician.

Many patients are interested in the question, is it possible to take enalapril with alcohol, including with low-alcohol drinks: beer, wine, etc. The answer to it can be given unequivocal - it is possible, but only for your own fear and risk. The fact is that, without exception, alcoholic beverages have a property to reduce blood pressure, and the drug itself has exactly the same effect.

As a result, the total pressure reduction may not only worsen your well-being, but also lead to much more serious consequences:

• oppression of the CNS,
• orthostatic collapse, etc.

Even with moderate consumption of alcohol, the reception of this medication in most cases leads to spontaneous weakness, dizziness, nausea, deterioration of perception and coordination of movements. Therefore, before taking enalapril at elevated pressure along with alcohol, it is worth thinking well - whether you need such risks.

At low pressure

Those interested in whether it is possible to take enalapril at low pressure, it should be remembered that this drug is hypotensive, and its main purpose is to lower hell. Accordingly, with low arterial pressure, its use in most cases is simply not advisable.

Nevertheless, Enalapril has a number of other useful influences that are not related to hypertension on the circulatory system:

• improves myocardial blood supply;
• reduces platelet aggregation;
• normalizes blood flow in the field of kidneys and brain;
• it has a diuretic effect.

Thanks to these peculiarities, you can make an enalapril at high pressure, and use it to combat other diseases of the circulatory system against the background of a reduced blood pressure. However, it is necessary to do it very carefully, and only under the supervision of the cardiologist.

Remember that under reduced systolic pressure (less than 110 mm Hg. Art. The recommended dose of Enalapril is only 1.25-2.50 mg per day.

How long is allowed to apply?

Another very important question - how long can it be taken by Enalapril, and does his human body use harm? On this score, you can be calm, as Enalapril refers to the category of medicines that can be taken throughout life without any negative health consequences. However, like all other heartbreaks, it requires strict control and regular diagnostics to assess the patient's current state.

Taking this medical agentYou should periodically pass the examination, controlling the picture of peripheral blood. According to the results of such a survey, it will be seen whether you can continue to use Enalapril, and how much to take it in time. It should also be noted that the refusal to receive tablets does not cause a sharp change of blood pressure to the direction of increasing, which again speaks in favor of this drug and highlights it among existing analogues.

Useful video

For more information about drugs against high pressure, see the following video:

Conclusion

1. On how to take enalapril properly, in general, you can learn from the official instructions for the drug.
2. To date, this antihypertensive agent is one of the most effective and inexpensive in its segment.
3. It must be remembered that in addition to explicit advantages, it has a considerable amount of contraindications and side effects that need to be considered when appointing it to use.

Enalapril is a hypotensive agent that is part of the ACE inhibitors group. The effect of the drug is associated with the effect on the renin-angiotensin-aldosterone system. She takes part in the control of blood pressure.

The noticeable effect of the use of the drug can be obtained by about 2-4 hours, while the initial effect is achieved in about an hour. It is possible to use the drug only to appoint a specialist.

Medicine ENALAPRIL is released in the form of tablets. The active component of the means - enalapril. Each tablet may present 5, 10 or 20 mg of the active substance.

Depending on the dosage, ENALAPRIL HL or Enalapril H can be prescribed. Additional ingredients include gelatin, lactose monohydrate. In addition, the medicine contains carbonate and magnesium stearate, crosspovidon.

Packaging is 20-30 tablets. Store the drug follows at a temperature of 15-25 degrees for 3 years. After this time, use the tool is prohibited. Many people are interested, how much is Enalapril. The price depends on the manufacturer and dosage. On average, cost ranges from 20 to 100 rubles.

pharmachologic effect

Its activity is aimed at suppressing angiotensin enzymes. Due to this, the synthesis of aldosterone is reduced. Some people are interested in what pressure is Enalapril. After its use, systolic and diastolic pressure decreases.

In addition, Enalapril tablets contribute to the expansion of blood vessels and improved blood circulation in the area of \u200b\u200bthe brain and kidneys. After a long use of the means, you can see the reduction in the left ventricular hypertrophy. This contributes to a slowdown or complete prevention of heart failure.

Due to the use of the drug, the blood supply to myocardium is improved. In addition, the drug has a certain diuretic effect and reduces platelet aggregation.

The pressure is reduced by about an hour, but the maximum effect can be seen in about 6 hours. It is saved for 24 hours. Some categories of patients need more prolonged therapy to achieve stable results. In such a situation, the drug takes several weeks.

If a person has a heart failure, the therapy lasts half a year. Only in this case will be able to achieve tangible clinical results.

Pharmacokinetics

After receiving, the absorption means is about 60%. Approximately half medicinal preparation binds to protein components. After taking the means, a metabolite is formed, which is absorbed by the body. The medicine is converted to enalaprilat, which is an active ACE inhibitor.

The drug can get into maternal milk and overcome a placental barrier. At high-rise medication takes 11 hours. Approximately 60% of the means is excreted by kidney, 33% leaves the body during defecation. Peritoneal dialysis and hemodialysis allows you to completely remove the drug.

Indications

The drug is usually prescribed in such situations:

• Renovascular hypertension;
• Heart failure.

If a person has pronounced heart failure, the medicine is used to solve such tasks:

• Improving the forecast;
• Slowdown in the development of alend;
• Reducing the number of hospitalizations.

Reviews of enalapril doctors show that it is necessary to take care of caution in the development of liver deficiency, the appearance of the stenosis of the kidney arteries, combined with immunosuppressants. The medicine is not recommended for diabetes and hypercalemia. It is very careful when weakening the body due to surgical interventions.

Side effects

Enalapril is able to provoke unwanted consequences for health:

1. Cardiovascular system can react to the use of medication with a strong pressure drop and orthostatic collapse. In rare cases, a person can appear pain syndrome Behind the sternum or infarction - these complications are usually due to excessive decrease in pressure. There is a risk of arrhythmia, heartbeat and thromboembolism of the artery of the lungs.
2. Violations in work nervous system May appear in the form of dizziness, weaknesses, headaches. A person can develop insomnia, depressive states, confusion of consciousness. Often, people complain about paresthesia, increased anxiety, drowsiness. When using a high dosage agent, there is a risk of nervousness.
3. Sensivities sometimes react to the drug to the appearance of problems with the vestibular apparatus, impaired hearing and vision, the occurrence of noise in the ears.
4. Defection of organs digestive system may be accompanied by a deterioration of appetite, dry in oral cavity, dyspeptic symptoms. In some cases, the intestinal obstruction is developing, hepatitis, pancreatitis, jaundice. Some people complain about the problems in the work of the liver and disruption of the selection of bile.
5. The respiratory system can react to the use of the means with an unproductive cough, the development of bronchospasm, pharyngitis, shortness of breath. Some people develop an interstitial pneumonite or rhinor.
6. The use of the drug can provoke allergies. It manifests itself in the form of rashes on the skin, angioedema edema of face, dysphony. Sometimes the feeling of itching, vasculitis, urticaria and other disorders arise.
7. The urinary system responds to the preparation of disorders in the work of the kidneys and the development of proteinuria.

Overdose

An overdose of enalapril is accompanied by a strong decrease in blood pressure, including the state of the collapse. A person can also develop a heart attack, acute circulatory disorders in the brain or thromboembolia. Often, patients face convulsive syndrome or stupor state.

To cope with negative consequences, the patient needs to lie down. And the head must be pretty low. In light cases, it is sufficiently washing the stomach and the internal use of the saline solution.

Medicinal interaction

In order for Enalapril to make exclusive benefits, you need to clearly comply with the instructions and remember the interaction of medication with other drugs:

1. A combination with anti-inflammatory drugs provokes a decrease in hypotensive action. A similar result is observed in excessive use of salts with food.
2. When used with potassium-saving diurets, there is a risk of hypercalemia.
3. Combination with lithium salts can slow down the removal of this substance.
4. Enalapril is able to reduce the effectiveness of drugs containing theophylline.
5. Symptoms of pressure drop are growing with diuretic use, beta adrenobloclars, nitrates. Similar results provoke prazosin, hydralazine.
6. Reception of cytostatics, immunosuppressants and allopurinol leads to increased hematotoxicity.

special instructions

With caution, the drug is prescribed to people having autoimmune pathologies, problems in the work of the liver and diabetes mellitus. The same applies to complex species of artery stenosis, hypertrophic cardiomyopathy, salts and liquid loss.

If before this man took saluretics and had chronic form Heart failure, there is a risk of orthostatic hypotension. Therefore, before the use of Enalapril, the loss of salts and liquid should be filled.

With prolonged use of the drug, it is necessary to monitor the characteristics of peripheral blood. The sharp cancellation of the drug does not lead to a sudden increase in pressure.

With operational interventions during therapy, Enalapril is the risk of hypotension. This state is corrected using the introduction of the required volume of fluid. Before assessing the work of the parathyroid glands, the use of the means must be canceled.

When driven by car and other complex mechanisms Care must be taken. The drug can provoke dizziness. This is especially true when using the initial dose of medication.