Surely every person is familiar with the symptoms of cold and flu. Unfortunately, many people belong to such a disease. Experts argue that with improper and late treatment of such states in the patient, serious complications may arise. Therefore, at the first signs of illness, you should immediately contact the doctor.

Modern pharmaceutical companies produce a huge number of different drugs against influenza and colds. One of the most popular is the Medication "Antigrippin-Anvi". Instructions for use, photos of medicines will be presented in the article.

Release form, composition, packaging and description

The drug "Antigrippine-Anvi", the instruction of which is invested in cardboard packaging, is made in the form of capsules. They can be of two types:

• Capsules and have green and special hardness. Their contents is a mixture of crystalline and amorphous mass of light yellow color (May have a green shade). It is also possible to the presence of lumps.
• Capsules b are white. Their contents are small granules or powder white color with a yellowish tint and with the presence of lumps.

For sale, such a drug enters the contour packaging (10 capsules and in one and 10 capsules b in another).

What ingredients contains "Antigrippin-Anvi"? The application instruction reports that the capsules A includes acetylsalicyl and rutoside in the form of trihydrate. Potato starch and calcium stearate are used as additional components.

As for the gelatin shell, it consists of a dye azoruba, a yellow chinoline dye, a black diamond dye, a patented blue or blue diamond, gelatin and titanium dioxide.

The capsule b includes calcium gluconate monohydrate, diphenhydream hydrochloride and sodium metamizole monohydrate. The auxiliary substances of this medicine are potato starch and calcium stearate. The composition of the shell includes the gelatin and titanium dioxide.

It should also be noted that there are other forms of the drug "Antigripin-Anvi". Instructions for use (effervescent pills will be described later) reports that chloropheniramine Maleat, paracetamol and ascorbic acid are active ingredients of this medication.

Pharmacological properties

What is the Medication "Antigrippin-Anvi"? The application instruction indicates that it is an antipyretic, angioprotective, anesthetic, anti-inflammatory and antihistamine drug. Its effectiveness is due to the presence of several existing components.

Ascorbic acid is able to adjust the redox processes, the exchange of carbohydrates, the regeneration of tissues and blood coagulation, as well as to increase the resistance of the body.

Acidity Acetylsalicyl, or aspirin, has an antipyretic, anti-inflammatory, painkillers and antiagregative effect.

Rutoside is a powerful angioprotector. It eliminates the symptoms of inflammation, reduces the permeability of capillaries, increases the deformation and weakens the aggregation of erythrocytes, and also stabilizes the vascular walls.

Diphenhydramine has antiallergic and anti-ethnic effect. Also, this substance reduces the permeability of the vessels, eliminates the reactions of hypersensitivity by the respiratory system, swelling and hyperemia of the mucous nose.

Sodium metamizol has a slight anti-inflammatory, antipyretic and analgesic effect, which is associated with the oppression of the biological synthesis of prostaglandins.

It is capable of adjusting the exchange of calcium and phosphorus. This ingredient has an antiallergic effect, and also reduces the permeability of the vessels. For therapy allergic diseases It is recommended to take together with antihistamine drugs.

Indications

Under what diseases the patient may be appointed a medicine "Antigrippin-Anvi"? Instructions for use (in capsules This agent is recommended only to adults and adolescents from 15 years) indicates that the drug in question is intended for the symptomatic treatment of influenza, acute viral diseases and colds.

Contraindications

Is there any contraindications from the drug "Antigrippin-Anvi"? Instructions for use, reviews indicate that this medication cannot be prescribed in the following states:

It should also be noted that the Medication "Antigrippin-Anvi", the instruction of which is described below, are prescribed with particular care to people with gout, hyperuricemia, urate nephrolithiasis, ulcerative disease and insufficiency (decompensated) cardiac activity.

Capsules "Antigrippin-Anvi": instructions for use

Capsules "Antigrippin-Anvi" are prescribed inside two pieces at a time (one capsule b and one capsule A). Reception medication is carried out after eating twice or three times a day.

Treatment time by this tool is 3-5 days. In the absence of the desired result, the reception of the medication should be stopped and refer to the doctor.

Swiming Tablets "Antigrippin-Anvi": Instructions

The mentioned form of the drug is also used inside. Maximum therapeutic effect It is achieved by drinking medication 30 minutes before or 2 hours after meals.

Before taking, effervescent tablets must be dissolved in 200 ml of warm water. The finished solution is immediately drinking. His storage is unacceptable.

The duration of therapy and the dosage of this medication are calculated individually.

Adolescents from 15 years are shown to receive 1 tablet of the drug 2-3 times a day. The minimum interval between the use of the medication is 4 hours. A day should take no more than three tablets.

The duration of treatment with the preparation under consideration is usually 3-5 days.

In renal or liver failure, as well as aged from 60 years, the gap between the drug intake should be 8 hours.

Sideflines

What negative reactions cause a medication "Antigrippin-Anvi"? The application instruction indicates the following side effects:

• gastralgy, bleeding, anorexia, vomiting, diarrhea, liver failure, erosive-ulcerative changes and nausea;
• lack of work of the kidneys;
• tachycardia and increase in pressure;
• rash, angioedema swelling and bronchospasm.

What adverse reactions occur with long-term admission of the drug "Antigrippin-Anvi"? Instructions (capsules and effervescent tablets cause the same undesirable phenomena) indicates the following effects:

• headache, Anuria and dizziness;
• defeat vision, noise in the ears;
• bronchospasm;
• weakening hypocoagulation and hemorrhagic syndrome;
• leukopenia, disruption of kidney, thrombocytopenia, vomiting and agranulocytosis;
• the development of anaphylactic shock, deafness, Stevens Syndrome - Johnson, Layella Syndrome;
• papillarous kidney necrosis, proteinuria, oliguria, urine coloring in red;
• development of children's syndrome in children (hyperpyrassia, liver damage, changes from the psyche).

Cases overdose

Instructions for the use of "Antigrippine-Anvi" reports that in the overdose of this tool, the patient may have the following symptoms:

To the treatment of such states, the stomach is washed, activated carbon and salt laxatives are used. In convulsions, it is recommended to introduce intravenously "diazepams".

Interaction with other medicines

With a simultaneous treatment of the drug with Spironolactone, Furosemide, antihypertensive and urikozuric means, their effectiveness significantly deteriorates.

When combined with heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents are enhanced by their action.

With the simultaneous use of medication with "zidovudine", barbiturates, "rifampicin", alcohol-containing drugs and antiepileptic agents, the risk of hepatotoxic action increases.

Ascorbic acid is able to strengthen the absorption of iron drugs in the intestine.

It should also be noted that the instruction on the use of Antigriaripin-Anvi indicates that this means enhances the side effects of glucocorticosteroids, non-constidium analgesics, sulfonylurea and methotrexate derivatives, as well as NSAIDs.

Sedatives and tranquilizers stimulate the analgesic effect of the drug under consideration.

What should the patient know before using the Antigippin-Anvi medicine? Instructions for use (tablets and capsules should be used only by testimony) argues that during long-term drug intake, it is necessary to analyze peripheral blood, and monitor the liver status indicators.

Acetylsalicylic acid in small dosages is able to reduce the evacuation of uric acid. This fact may lead to the exacerbation of the gout.

During treatment with this means, patients need to eliminate the taking of alcohol-containing beverages due to the possible development of bleeding from the gastrointestinal organs.

An acid intake ascorbic people with intensively metastatic cancer can provoke a deterioration in the course of the disease.

During the use of the drug, it is necessary to exclude vehicle management.

Pregnancy period and breastfeeding

The instruction on the use of "Antigrippin-Anvi" reports that when entering the fetus, it is forbidden to assign this tool. If it is necessary to use the drug during breastfeeding, lactation should be discontinued.

Cost and similar means

You can purchase the preparation in the pharmacy at a well-reasonable price (about 150-200 rubles).

In the event that the Medicine "Antigrippin-Anvi" is contraindicated to the patient, it is replaced with such means as "antigrippin-maximum", "Antigrippin", "Teraflex", "Antiflu Kids", "Rensa" and other.

Instruction

by medical application medicinal preparation

"Antigrippin" -

Trade name

"Antigrippin" -

International non-proprietary title

Dosage form

Pills

Composition

One tablet contains

active substances: Paracetamol - 0.25 g, acid ascorbic - 0.15 g, calcium gluconate - 0.05 g, Dimedrol - 0.01 g, Rutin - 0.01 g,

excipients: Starch, talc, calcium stearate.

Description

Tablets of yellowish color with a flat surface, with a chamfer and risk.

Pharmacotherapeutic group

To eliminate symptoms of cold and cough. Other combinations of drugs to eliminate cold symptoms.

ATH code R05x

Pharmacological properties

The pharmacological activity of the drug is due to the properties of the active ingredients in its composition.

Pharmacokinetics

After taking inside, paracetamol is quickly absorbed from the gastrointestinal tract, is widely distributed in tissues and in liquid media, with the exception of adipose tissue and spinal fluid. Proteins binding is less than 10%. Metabolized mainly in the liver, is excreted with urine, mainly in the form of glucuronide and sulphate conjugates. Paracetamol penetrates through a placental barrier and stands out with breast milk.

Ascorbic acid is well absorbed after oral administration. About 25% binds to plasma proteins, postponed in plasma and cells, the greatest concentration is achieved in ferrous tissues (mainly in the adrenal cortex and hypophysies). Metabolized in the liver, is displayed with urine in the form of oxalate and unchanged.

After intake, about 30% of ionized calcium is absorbed into the gastrointestinal tract. After oral administration, the maximum concentration in the blood plasma is reached after 1.2-1.3 hours. Excreted from the body mainly with a fee (80%) and urine (20%).

Dimedrol is quickly absorbed from the gastrointestinal tract. Bioavailability is 50%. Binding with plasma proteins - 98-99%. Penetrates through the BC. Metabolized mainly in the liver, partly - in lungs and kidneys. During the day, the kidneys in the form of metabolites is fully removed. Also excreted with milk and can cause a sedative effect in breast-age children.

The maximum routine concentration after intake is reached after 1-9 h. It is removed mainly with biliary and to a lesser extent - the kidneys.

Pharmacodynamics

Paracetamol has an analgesic, antipyretic and weak anti-inflammatory effect. The mechanism of action is associated with inhibiting the synthesis of prostaglandins, preferably influenced by the center of thermoregulation in the hypothalamus.

Ascorbic acid replenishes the deficiency of vitamin C in the body, has pronounced antioxidant properties, regulates redox processes, increases the body's resistance to infections.

Calcium gluconate has an antiallergic, hemostatic effect, reduces the fragility and permeability of the vessels, the symptoms of the lack of calcium in the body improves muscle contraction during muscle dystrophy, myasthenia.

DiMedrol has antiallergic activity, has a local substares, antispasmodic and moderate gangli-blocking effect. When taking inside, it causes a sedative and hypnotic effect, has a moderate antiemetic effect.

Angioprotector Rutin belongs to the group of vitamin P, in combination with ascorbic acid, reduces the permeability and incidence of capillaries, is involved in oxidative and reduction processes, has antioxidant properties.

Indications for use

Symptomatic treatment influenza and other sharp respiratory viral infectionsaccompanied by fever, sore throat, headache, rhinitis.

Method of application and dose

Adults are prescribed inside 1 tablet 3 times a day; Children over 7 years old on ½ tablet 3 times a day after meals for 3-5 days. Maximum motherwise dose For adults - 2 tablets, daily - 6 tablets; For children over 7 years old - 1 tablet and 3 tablets, respectively. The drug is not recommended to apply more than 5 days without a consultation with the doctor. If the symptoms are saved, you should contact a doctor.

Side effects

Dyspeptic phenomena, dry mouth, epigastric pain, nausea, vomiting, irritation of the mucous membrane of the gastrointestinal tract, long use In high doses, paracetamol can have a hepatotoxic, nephrotoxic effect

Headache, feeling of fatigue, drowsiness, increase excitability of CNS, sleep disorder, reducing the velocity of psychomotor reactions, in children DIDEDROL can cause paradoxical development of insomnia, irritability and euphoria

With long-term use in high doses, the function of the pancreatic insular apparatus is possible (hyperglycemia, glucosuria), hyperoxaluria and the formation of urinary stones from calcium oxalate

Reducing the permeability of capillaries and deterioration of tissue trophics

Thrombocytosis, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase deficiency), hyperprotrombinemia, erythroaction, neutrophilic leukocytosis, hypokalemia

Allergic reactions: urticaria, skin itch, Skin hyperemia

Difficult urination (especially in men with increased prostate gland)

Increased viscosity of the secrets of the respiratory tract

About all side Effects, Including not specified above, should be informed of the doctor and stop taking the drug.

Contraindications

- individual intolerance to any components that are part of the drug

Heavy violations of liver and kidney function

Chronic alcoholism

Erosive-ulcerative lesions of the gastrointestinal tract (in the aggravation phase)

Gastrointestinal bleeding

Blood diseases with tendency to hemorrhage

Renal disease (or availability this disease in history)

Epilepsy

Children's age up to 7 years

Pregnancy and lactation period

Anemia, leukopenia

Glucose-6-phosphate dehydrogenase deficit

Medicinal interaction

With simultaneous use with inductors of microsomal liver enzymes, means of hepatotoxic effect (salicylamides, barbiturates, antiepileptic agents, tricyclic antidepressants, alcohol, rifampicin), there is a risk of increased hepatotoxic action of paracetamol (the level of toxic metabolites increases).

Simultaneous use with doxorubicin increases the risk of violation of the liver function.

With simultaneous use with oral contraceptives, the removal of paracetamol is accelerated from the body and it is possible to reduce its analgesic action.

Activated carbon decreases paracetamol bioavailability.

With simultaneous use with anticoagulants, a small or moderate increase in prothrombin time is possible, the danger of bleeding increases.

With simultaneous use with methaclopromide and domperidone, an increase in paracetamol absorption is possible and an increase in its concentration in the blood plasma, and the cholestyramine reduces the concentration of paracetamol.

Cases of manifestation of the toxic effect of paracetamol are described while simultaneously use with isoniazid, reduces paracetamol clearance.

Cases of hepatotoxicity are described with the simultaneous use of paracetamol and phenobarbital. Hepatotoxic effect is enhanced in the presence of ethanol.

Carbamazepine, phenytoin, phenobarbital, prison reduce the effectiveness of paracetamol.

The interaction with drugs more often occurs with the long-term use of large doses of ascorbic acid.

Ascorbic acid increases the concentration in the blood of salicylate (increases the risk of crystaluria), ethinyl estradiol, benzylpenicillin and tetracycline.

Estrogen - increases the level of hormone in serum.

With oral catrators containing estrogens - contraceptive effect decreases.

Reduces the anticoagulation effect of Cumarine and Heparin derivatives.

Improves suction in the intestines of iron preparations.

Increases general clearance ethyl alcoholwhich in turn reduces the concentration of ascorbic acid.

The drugs of quinoline series, calcium chloride, salicylates, corticosteroids with prolonged use of ascorbic acid reserves.

Acetylsalicylic acid, oral contraceptives, fresh juices And alkaline drink reduce the suction and absorption of ascorbic acid. With the simultaneous use of ascorbic acid with isoprenaline, the chronotropic effect of the latter decreases. In high doses increases the removal of Mexyleletina by the kidneys. Barbiturates and pyrimidine increase the removal of ascorbic acid with urine. Ascorbic acid reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, canaline reabsorption of amphetamine and tricyclic antidepressants.

With the simultaneous use of DIMEDROL enhances the effect of ethanol and preparations, depressing CNS, barbiturates, sleeping pills, opiate analgesics. Therefore, when the joint use of these drugs should be consulted with a doctor to avoid potentiated action.

Mao inhibitors enhance the anticholinergic activity of Dimedrol.

Antagonistic interaction is observed with joint appointment with psychostimulants.

Reduces the effectiveness of apomorphine as a vomit in the treatment of poisoning.

Enhances the anticholinergic effects of drugs with cholin-blocking activity.

Calcium can reduce the absorption of tetracycline antibiotics and fluorine preparations with simultaneous reception. The simultaneous use of vitamin D increases calcium suction. Due to the possibility of the formation of non-calciting complexes, calcium can reduce the absorption of the etramstine, ethydronate, and possibly other bisphosphonates, phenytoin, quinolones, oral tetracycline antibiotics and drugs should be at least 3 hours. The absorption of calcium from the gastrointestinal tract can decrease with simultaneous reception of some types of food, for example , spinach, rhubarb, bran and grain. When prescribing high doses of calcium with patients receiving drugs, can increase the risk of arrhythmias. Tiazide diuretics reduce the excretion of calcium with urine. Therefore, it should be kept in mind the risk of developing hypercalcemia when they are simultaneously use.

The pharmacological effect of the routine is amplified by ascorbic acid. Rutin protects ascorbic acid and adrenaline from oxidation.

special instructions

Do not apply other paracetamol containing drugs in the treatment of "antigrippin" -P. Caution is used in patients with impaired liver and kidney function. Do not combine with intake of sleeping equipment.

Paracetamol caution is prescribed when chronic diseases liver and kidney, gout, ulcerative gastric disease and duodenal gut (a history of). The degree and nature of the functional changes in these organs should be taken into account, since these patients may increase the half-life of paracetamol. Paracetamol can influence the results of determining uric acid in the blood using phosphorus-tungstenic acid and the determination of glycemia by glucose-oxidase-peroxidase. When taking the drug and during the manifestation of its operation, the use of alcoholic beverages is prohibited.

Given the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to control the kidney function and blood pressure. Ascorbic acid in patients with rapidly proliferating and intensively metastatic tumors can be aggravated during the disease. Ascorbic acid can distort the results of various laboratory tests (determining the content of glucose, bilirubin and activity of hepatic transaminases, LDH in the blood plasma). Ascorbic acid is prescribed with caution to patients with hyperoxalatera. Calcium gluconate must be used with caution to patients with renal failure, or with diseases associated with elevated levels of vitamin D, sarcoidosis type diseases.

On all side (unusual) effects, including those not specified above, should be informed of the doctor.

In the absence of improved well-being, the reception of the drug should be stopped and consult a doctor. If the patient is preserved surgical interventionHe must warn the doctor in advance about the reception of the drug.

Pregnancy and lactation period

The use of the drug during pregnancy and lactation is not recommended.

Features of the effect of the drug on the ability to control the vehicle or potentially hazardous mechanisms

Caution is used in patients engaged in potentially hazardous species Activities requiring increased attention and rapid psychomotor reactions.

Overdose

There are symptoms of overdose of diphrol and paracetamol: nausea, vomiting, dry mouth, expansion of pupils, depression of CNS, convulsions, developmental development (especially in children) or depression. Signs of hypercalcemia: anorexia, nausea, vomiting, violation of consciousness, nephocalcinosis, calciuria and in serious cases of arrhythmia and coma.

Treatment: washing the stomach with water with activated carbon and conducting symptomatic therapy, forced diurea, hemodialysis. Antidot paracetamol acetylcysteine.

Release form and packaging

Tablets of 10 pieces in the contour bauble packing of wrapping paper with a polymer coating on both sides. 250 contour bale-free packages together with the instructions for medical use in public and Russian are placed in a cardboard box (group packaging).

10 tablets in the contour bale-free packing made of aluminum foil coated with PVC film. On 2 contour bale-free packages made of aluminum foil coated with PVC film, together with the instructions for medical use in public and Russian, are placed in a pack of cardboard. 55 packs of cardboard pose in a cardboard box (group packaging). For 200 contour bale-free packages from aluminum foil coated with PVC film, together with the instructions on the copper-zinc applied at the state and Russian languages, help in a cardboard box (group packaging).

Storage conditions

In a dry, light-protected place at a temperature not higher than 25 ° C.

Keep out of the reach of children!

Storage term

Do not use the drug after the expiration date.

Conditions of vacation from pharmacies

On prescription

Manufacturer

Owner registration certificate

Eykos-Farm LLP, Republic of Kazakhstan, Almaty region, pos. Boralday, 71 travels.

Address of the organization hosting on the territory of the Republic of Kazakhstan Claims (suggestions) from consumers for the quality of medicines, responsible for the post-registration monitoring of the security of the drug

almaty, ul. Nusupbekova, 32.

tel: 397 64 29, Fax: 250 71 78

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Antigrippin (paracetamol + ascorbic acid + chloropenamine) is a combined drug for symptomatic pharmacotherapy of sharp respiratory viral infections (ORVI). The latter's share according to the statistics of the World Health Organization accounts for up to 90% of all clinical cases. infectious diseases. Every year, tens of millions of people become victims of ARVI in our country. Each particular case of the disease has its own specific features: so, influenza viruses, adenoviruses and respiratory-syncitial viruses attack the epithelium of the upper and lower hotels of the respiratory tract, rhinoviruses affect the nasal cavity epithelium, paragrippa viruses - larynx, adenoviruses cause conjunctivitis. Similar "gripping campaigns" occur as follows: infection pathogens, having affinity for the mucous membrane of the respiratory tract, are introduced into epithelial cells, launching flywheel local inflammatory reaction. The resulting decay products of cells "poison" systemic bloodstream toxins, resulting in a familiar painting picture with claims to clinical: head and muscle pain, lethargy, weakness, fever, local reactions (cough runny nose, error and sore throat). In the treatment of ARVI many pitfalls, but big problem Here is the impossibility of prescribing pathophysiological therapy aimed at the cause of the disease. In this regard, practical doctors have to be content with symptomatic treatment. Fortunately, today there is a whole arsenal of medicines, including non-steroidal anti-inflammatory drugs, anti-inflammatory (removing mucous membranes) agents, antitussive tools, bronchopholics, immunomodulators, etc. But the purpose of antibiotics during ORV is not always appropriate and justifies itself only in the case of an attached bacterial infection. Since there are many different viruses for the emergence of ARVI, the optimal option for the symptomatic treatment of this group of diseases should be considered to be the use of certain combined drugs that can cover the entire symptom complex of ARVI.

Non-steroidal anti-inflammatory agent Paracetamol is one of the most frequent components of such drugs. Its antipyretic effect is implemented through the suppression of the synthesis in the CNS of the mediators of inflammation of prostaglandins, which becomes possible due to the ability of the drug to inactivate cyclooxygenase. From other NSAIDs paracetamol distinguishes its safety against the gastrointestinal tract: it blocks the synthesis of prostaglandins in the hypothalamic centers of thermoregulation and pain, without affecting other organs and tissues. In order to prevent the nasal congestion, antihistamines are injected into combined anti-violent drugs medicinal productsFor example, chloropenamine: it eliminates the symptoms of allergies (sneezing, redness of the eyes, tearing), facilitates nasal breathing. Another "frequenter" of multisimitious means of combating manifestations of ARVI - vitamin C or ascorbic acid. It stimulates the production of interferon immune protein, normalizes the processes of free radical oxidation of lipids, reduces the permeability of the vascular wall, eliminates the deficiency in itself, developed against the background of the disease. The drug Antigrippin, which includes all of the above components, is today one of the most balanced anti-violence complexes. It is produced in the form of soluble tablets with a variety of tastes. Take the drug should be between meals 1 tablet 2-3 times a day, dissolving them in a glass of warm water. The maximum daily dose should not exceed the 3rd tablets. The duration of the use of antigrippine as part of self-treatment is not more than 5 days (as an anesthetic) and no more than 3 days (like antipyretic). The drug does not contain sugar (with the exception of the Romashkova and medical-lemon flavoring form), therefore, it can be used in patients suffering from diabetes.

Pharmacology

Combined drug.

Paracetamol has an analgesic and antipyretic effect; Eliminates the head and other types of pain, reduces the elevated temperature.

Ascorbic acid (vitamin C) is involved in the regulation of redox processes, carbohydrate metabolism, increases the body's resistance.

Chloropenamine - Blocator H 1 -Histamine receptors, has an antiallergic effect, facilitates breathing through the nose, reduces the feeling of nasal congestion, sneezing, tearing, itching and redness of the eyes.

Form release

Powder for preparing a solution for intro medical and lemon or chamomile.

5 g - bags of combined material (10) - packs cardboard.

Dosage

Inside. Adults and children over 15 years old - 1 sachet 2-3 times a day. The contents of the package should be completely dissolved in a glass (200 ml) of warm water (50-60 ° C) and the solution obtained immediately drink. It is better to take the drug between meals. Maximum daily dose - 3 bags. The interval between the drugs should be at least 4 hours.

In patients with impaired liver or kidney function and in elderly patients, the interval between the drugs should be at least 8 hours.

The duration of reception without consultation with the doctor is not more than 5 days when appointing as an anesthesia and 3 days as an antipyretic agent.

Overdose

The symptoms of overdose by the drug are caused by the substances included in its composition. The clinical picture of acute intoxication by paracetamol is developing within 6-14 hours after its reception. Symptoms of chronic intoxication are manifested in 2-4 days after overdose.

Symptoms of acute intoxication Paracetamol: diarrhea, decreased appetite, nausea and vomiting, discomfort in abdominal cavity and / or abdominal pain, raising sweating.

Symptoms of intoxication chlorophenamine: dizziness, excitation, sleep disorders, depression, convulsions.

Treatment: symptomatic.

Interaction

Vitamin C

Increases the blood concentration of benzylpenicillin and tetracycline;

Improves suction in the intestines of iron preparations (translates the trivalent iron into a divalent); can increase iron excavation while simultaneously use with deferoxamine;

Increases the risk of crystallurium development in the treatment of sualicylate and short-acting sulfanimides, slows down with kidney acids, increases the removal of drugs having an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives.

Enhances the general clearance of ethanol;

With simultaneous use, it reduces the chronotropic effect of isoprenaline.

It can both increase and reduce the effect of anticoagulant drugs. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, canaline reabsorption of amphetamine and tricyclic antidepressants.

The simultaneous reception of barbiturates increases the removal of ascorbic acid with urine.

Chloropenamine Maleat

Chloropenamine Maleat enhances the effect of sleeping pills.

Antidepressants, anti-parkinsonic agents, antipsychotic means (derivatives of phenothiazine) - increase the risk of developing side effects (urine delay, dry mouth, constipation). Glucocorticosteroids - increase the risk of glaucoma. Ethanol enhances the sedative effect of chloropenamine Maleat.

Paracetamol

When the interaction of paracetamol and inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutays, tricyclic antidepressants) increases the products of hydroxylated active metabolites, which causes the possibility of developing severe intoxication with small overdoses.

Against the background of receiving paracetamol ethanol contributes to the development of acute pancreatitis ..

Microsomal oxidation inhibitors (including cimetidine) reduce the risk of hepatotoxic action.

The simultaneous reception of difluunisale and paracetamol increases the concentration in the plasma of the blood of the latter by 50%, increasing hepatotoxicity. The simultaneous reception of barbiturates reduces the effectiveness of paracetamol.

Paracetamol reduces the effectiveness of uricozeuric drugs.

Side effects

In isolated cases, there are:

from the CNS: Headache, feeling of fatigue;

from the gastrointestinal tract: nausea, pain in the epigastric region;

from side endocrine system: hypoglycemia (up to coma development);

from the side of the blood formation organs: anemia, hemolytic anemia (especially for patients with glucose-6-phosphate dehydrogenase); extremely rarely thrombocytopenia;

allergic reactions: skin rash, itching, urticaria, swelling of quinque, anaphylactoid reactions (incl. anaphylactic shock), multiform exudative erythema (incl. Stevens-Johnson syndrome), toxic epidermal necroliz (Lyleel syndrome);

others: hypervitaminosis with disruption of metabolism, feeling of heat, dry mouth, accommodation paresis, urine delay, drowsiness. All side effects of the drug should be reported to the doctor.

Indications

• infectious inflammatory diseases (ARVI, flu) accompanied by increased temperature, chills, headache, pain in the joints and muscles, nasal congestion and sore throat and sinuses of the nose.

Contraindications

• increased sensitivity to paracetamol, ascorbic acid, chlorophenamine or any other component of the drug;
• erosive-ulcerative lesions of the gastrointestinal tract (in the aggravation phase);
• pronounced renal and / or liver failure;
• alcoholism;
• clotted glaucoma;
• phenylketonuria;
• prostate hyperplasia;
• children's age up to 15 years;
• pregnancy and lactation period.

With caution: renal and / or liver failure, shortage of glucose-6-phosphate dehydrogenase, congenital hyperbilirubinemia (zhilbera syndromes, Dubbi-Johnson and Rotor), viral hepatitis, alcohol hepatitis, elderly age.

Features of application

Application in pregnancy and breastfeeding

Application with violations of liver function

Application with violations of the kidney function

Application in children

special instructions

When taking Metoklopramid, Domperidon or Kolistramine also need to be consulted with a doctor.

With long-term use in doses, significantly exceeding the recommended, the likelihood of violation of the liver and kidney function increases, is necessary to control the peripheral pattern of blood.

Paracetamol and ascorbic acid can distort the laboratory studies (quantitative determination of the content of glucose and uric acid in the blood plasma, bilirubin, activity of "liver" transamamine, LDH).

To avoid toxic lesion of the liver, paracetamol should not be combined with the reception of alcoholic beverages, as well as to take to persons prone to chronic alcohol consumption. The risk of developing damage to the liver increases in patients with alcoholic hepatosis.

The purpose of ascorbic acid to patients with rapidly proliferating and intensively metastatic tumors can be aggravated by the course of the process. In patients with elevated iron content in the body, ascorbic acid should be used in minimal doses.

In one bag of honey-lemon contains 1.793 g of sugar, which corresponds to 0.15 x.

In one chamomile sachet contains 2.058 g of sugar, which corresponds to 0.17 x.

Tablets of greenish yellow or yellow with insignificant splashes, round, flat surface, with a chamfer and risk.

Pharmacotherapeutic group

To eliminate symptoms of cold and cough. Other combinations of drugs to eliminate cold symptoms.

ATH code R05x

Pharmacological properties

The pharmacological activity of the drug is due to the properties of the active ingredients in its composition.

Pharmacokinetics

Ascorbic acid is well absorbed after oral administration. About 25% binds to plasma proteins, postponed in plasma and cells, the greatest concentration is achieved in ferrous tissues (mainly in the adrenal cortex and hypophysies). Metabolized in the liver, is displayed with urine in the form of oxalate and unchanged. After intake, about 30% of ionized calcium is absorbed into the gastrointestinal tract. After oral administration, the maximum concentration in the blood plasma is reached after 1.2-1.3 hours. Excreted from the body mainly with a fee (80%) and urine (20%).

Dimedrol is quickly absorbed from the gastrointestinal tract. Bioavailability is 50%. Binding with plasma proteins - 98-99%. Penetrates through the BC. Metabolized mainly in the liver, partly - in lungs and kidneys. During the day, the kidneys in the form of metabolites is fully removed. Also excreted with milk and can cause a sedative effect in breast-age children.

The maximum routine concentration after intake is reached after 1-9 h. It is removed mainly with biliary and to a lesser extent - the kidneys.

Pharmacodynamics

Ascorbic acid replenishes the deficiency of vitamin C in the body, has pronounced antioxidant properties, regulates redox processes, increases the body's resistance to infections.

Calcium gluconate has an antiallergic, hemostatic effect, reduces the fragility and permeability of the vessels, the symptoms of the lack of calcium in the body improves muscle contraction during muscle dystrophy, myasthenia.

DiMedrol has antiallergic activity, has a local substares, antispasmodic and moderate gangli-blocking effect. When taking inside, it causes a sedative and hypnotic effect, has a moderate antiemetic effect.

Angioprotector Rutin belongs to the group of vitamin P, in combination with ascorbic acid, reduces the permeability and incidence of capillaries, is involved in oxidative and reduction processes, has antioxidant properties.

Indications for use

Symptomatic treatment of influenza and other sharp respiratory viral infections.

Method of application and dose

Adults are prescribed inside 1 tablet 3 times a day; Children over 7 years old on ½ tablet 3 times a day after meals for 3-5 days. Maximum single dose for adults - 2 tablets, daily - 6 tablets; For children over 7 years old - 1 tablet and 3 tablets, respectively. The drug is not recommended to apply more than 5 days without a consultation of the doctor. If the symptoms are saved, you should consult a doctor.

Side effects

Dyspeptic phenomena, pain in epigastria, nausea, vomiting, dry mouth

Headache, feeling of fatigue, drowsiness, increase excitability of CNS, sleep disorder, reducing the velocity of psychomotor reactions, in children DIDEDROL can cause paradoxical development of insomnia, irritability and euphoria

With long-term use in high doses, the function of the pancreatic insular apparatus is possible (hyperglycemia, glucosuria), hyperoxaluria and the formation of urinary stones from calcium oxalate

Reducing the permeability of capillaries and deterioration of tissue trophics

Thrombocytosis, thrombocytopenia, leukopenia, neutropenia, agranulocy-tension, anemia, hemolytic anemia (especially for patients with a glucose-6-phosphate dehydrogenase deficiency), hyperprotrombinemia, erythroaction, neutrophilic leukocytosis, hypokalemia

Allergic reactions: urticaria, skin itch, skin hyperemia

Difficult urination (especially in men with increased prostate gland)

Increased viscosity of the secrets of the respiratory tract

Vitamin C:

From the side of the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg / day), with long-term use of large doses - hyperoxalura, nephrolityiasis (oxalace calcium), damage to the glomerular kidney apparatus.

From side digestive system: irritation of the mucous membrane of the gastrointestinal tract, with long-term use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis

Allergic reactions: skin rash, skin hyperemia.

Laboratory indicators: thrombocytosis, hyperpritombinemia, erythroaction, neutrophilic leukocytosis, hypokalemia, glucosuria.

Calcium gluconate:

Irritation of the mucous membrane of the gastrointestinal tract

Hypercalcemia.

Dimedrol:

Allergic reactions: urticaria, skin rash, itching, anaphylactic shock.

From side nervous system: dizziness, drowsiness, nervousness, insomnia, euphoria, general weakness, headache, violation of coordination of movements, anxiety, increased excitability (especially in children), irritability.

From the digestive system: dry mouth, short-term numbness of the oral mucosa, anorexia, diarrhea, epigastric distress, vomiting.

From the side of the respiratory system: dryness of the mucous membrane of the oral cavity, nose, bronchi (raising the viscosity of sputum), standinality in the chest.

From the side of the blood formation: hemolytic anemia, agranulocytosis.

From the urinary system: impairment of urination.

Allergic reactions: skin rash, itching.

From the digestive system: attacks of nausea, heartburn, diarrhea.

From the nervous system: headache.

Rutin can cause the "tides" of blood to the face.
All side effects, including those not specified above, should be informed of the doctor and stop taking the drug.

Contraindications

Increased sensitivity To the components of the drug

Epilepsy

Children's age up to 7 years

Pregnancy and lactation period

Medicinal interaction

The interaction with drugs more often occurs with the long-term use of large doses of ascorbic acid.

Ascorbic acid increases the concentration in the blood of salicylate (increases the risk of crystaluria), ethinyl estradiol, benzylpenicillin and tetracycline.

Estrogen - increases the level of hormone in serum.

With oral contraceptives containing estrogens - reduced contraceptive effect.

Reduces the anticoagulant effect of Cumarine derivatives.

Improves suction in the intestines of iron preparations.

Increases the general clearance of ethyl alcohol.

The drugs of quinoline series, calcium chloride, salicylates, corticosteroids with prolonged use of ascorbic acid reserves.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid. With the simultaneous use of ascorbic acid with isoprenaline, the chronotropic effect of the latter decreases. In high doses increases the removal of Mexyleletina by the kidneys. Barbiturates and pyrimidine increase the removal of ascorbic acid with urine. Ascorbic acid reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - derivatives of phenothiazine, canaline reabsorption of amphetamine and tricyclic antidepressants.

Calcium gluconate. Due to the possibility of the formation of non-calciting complexes, calcium can reduce the absorption of the etramstine, ethydronate, and possibly other bisphosphonates, phenytoin, quinolones, oral tetracycline antibiotics and drugs should be at least 3 hours. The absorption of calcium from the gastrointestinal tract can decrease with simultaneous reception of some types of food, for example , spinach, rhubarb, bran and grain. When prescribing high doses of calcium with patients receiving drugs, can increase the risk of arrhythmias. Tiazide diuretics reduce the excretion of calcium with urine. Therefore, it should be kept in mind the risk of developing hypercalcemia when they are simultaneously use.

Calcium can reduce the absorption of tetracycline antibiotics and fluorine preparations with simultaneous reception. The simultaneous use of vitamin D increases calcium suction.

With the simultaneous use of DIMEDROL enhances the effect of ethanol and preparations, depressing CNS, barbiturates, sleeping pills, opiate analgesics. Therefore, when the joint use of these drugs should be consulted with a doctor to avoid potentiated action.

Mao inhibitors enhance the anticholinergic activity of Dimedrol.

Antagonistic interaction is observed with joint appointment with psychostimulants.

Reduces the effectiveness of apomorphine as a vomit in the treatment of poisoning.

Enhances the anticholinergic effects of drugs with cholin-blocking activity.

The pharmacological effect of the routine is amplified by ascorbic acid.

special instructions

During the treatment period, it is necessary to avoid alcohol consumption. Do not combine with intake of sleeping equipment.

Given the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to control the kidney function and blood pressure. Ascorbic acid in patients with rapidly proliferating and intensively metastatic tumors can be aggravated during the disease. Ascorbic acid can distort the results of various laboratory tests (determining the content of glucose, bilirubin and activity of hepatic transaminases, LDH in the blood plasma). Ascorbic acid is prescribed with caution to patients with renal failure, or with diseases associated with elevated levels of vitamin D, sarcoidosis type diseases.

On all side (unusual) effects, including those not specified above, should be informed of the doctor.