With ulcery disease, the gastrointestinal tract is important to choose medical agentso that it does not bring even more harm. Doctors are written out by the "Rabeprazole" or "omez", which have the same action. What do they differ and in what cases to receive one or another medication can be read in this article.

Anti-sized preparation gastric juice and the severity of ulcer-erosive formations on the mucous membranes of the gastrointestinal organs. Protects the mucous membrane of the stomach.

Contains a substance rabeprazole. Produced in tablets and capsules coated with an intestinal-soluble shell.

Indications:

• The ulcer of the stomach and intestines in the stage of exacerbation.
• Gastritis.
• Syndrome Zlinger Ellison.
• Ulcerative disease caused by bacteria Helicobacter. Pylory (together with antibacterial agents).
• Preventing the recurrences of peptic disease caused by Helicobacter Pylory.

It is impossible to use in the intolerance of components, glucose-galactose malabsorption, lactase lactase disadvantage, intestinal infectionsduring pregnancy and lactation. Caution apply to persons up to 18 years and patients with heavy renal failure.

Method of application: 10 or 20 mg once a day. The course of therapy depends on the type of pathology, its degree and individual characteristics of the body. If necessary, the duration of treatment can be extended.

Before starting treatment, you need to eliminate the presence malignant tumor organs of the digestive tract.

Recommended by prescription.

Anti-sized preparation. Reduces the acidity of gastric juice and the severity of erosive-ulcerative lesions of the gastrointestinal organs, protects the gastric mucosa.

The active substance is omeprazole. The medication is produced in the form of capsules, powder for the preparation of suspension, lyophilisate for the preparation of the solution for infusion.

Indications:

• The ulcer of the stomach and the duodenal intestine (treatment and prevention of recurrences).
• Gastroesophageal reflux disease.
• Gastritis.
• Syndrome Zlinger Ellison.
• Hyperscecretory stomach states (polylendocrine adenomatosis, systemic mastocytosis, etc.).
• Ulcerative lesions of the gastrointestinal tract caused by prolonged intake of the NSAID.
• Preventing the recurrences of peptic disease caused by the Bacteria Helicobacter Pylory.
• Flatulence.

This therapeutic agent cannot be taken with the intolerance of the components during pregnancy and lactation, in childhood. With caution, apply patients with acute renal or liver failure.

Mode of application:

1. Under peptic ulcer, reflux-esophagitis, diseases caused by a long adoption of the NSAIDs - 2 tablets twice a day or one Sasha once a day; 40mg of lyophilisate to enter for 20-30 minutes once a day;
2. With Zollinger-Ellison syndrome 60mg per day.
3. For the eradication of Helicobacter Pylory - 2 tablets per day.

The course of therapy depends on the type of pathology, its degree and individual characteristics of the body. If necessary, the duration of treatment can be extended.

Before starting therapy, it is necessary to eliminate the presence of a malignant tumor of the digestive tract organs.

Recommended by prescription.

Comparison

Both drugs relate to one pharmacological group - proton pump inhibitors, that is, designed to treat pathologies caused by increased production of hydrochloric acid in the stomach. They reduce the secretion of acid in the stomach and severity of ulcers, protect the organ mucosa.

They have the same indications for use: gastroesophal reflux, gastritis, ulcer, Zollinger-Ellison syndrome, etc. But "omez" is also intended for the treatment of pathologies caused by a long habit of non-steroidal anti-inflammatory agents and hypersecreator states of the stomach.

The active substances of medical preparations are also different: the first contains Rabeprazole, and the second is omeprazole.

Overteement has more medicinal forms - Capsules, powder and lyophilisate. This allows you to choose the most convenient way of treatment. "Rabeprazole" is produced in tablets and capsules, that is, it can be used only orally.

It is proved that after the cessation of the reception of Rabeprazole, there is no "cancellation syndrome", that is, there is no sharp increase in the acidity of the stomach. In some patients, this symptom was observed in the treatment of "omise".

Both medicines are discharged.

What to choose

For the treatment of ulcers, which arose as a result of the infection of Helicobacter Pylory, it will suit any of these funds, as they are equally effective for the destruction of the bacteria.

With gastroesophageal reflux, experts recommend taking "Rabeprazole".

If you want to choose a medicine for a pregnant woman, then "Rabeprazole" is recommended, since it is more secure and has the smallest number side Effects. During the lactation, you can use any remedy, but at the time of treatment it is recommended to transfer the child to artificial feeding And do not give him breast milk.

"Omez" should be chosen to the patients who for a long time applied NSAIDs, and as a result, they have developed a peptic disease.

If the patient experiences difficulties with swallowing or not able to take food or medicines itself, then he is appointed "omez" in the form of infusions.

Experts found out that "Rabeprazole" to more symptomatic therapy and reduces the secretion of hydrochloric acid in the stomach, and the "omez" acts on peptic lesions. Therefore, the choice of drug depends on the stage of the disease, individual characteristics and contraindications. When gastritis is more suitable for the first remedy, and with installed ulcer-erosive lesions (including in the aggravation stage) - "Omez".

It must be remembered that only a specialist should be prescribed. Self-medication can lead to complications.

A drug:

International name: Rabeprazole
Dosage form: Tablets covered with pastry-soluble shell

Pharmachologic effect:
The anti-sized means from the group of proton pump inhibitors (H + / K + -atf-Aza) is metabolized in stomach parietal cells to active sulfonamide derivatives, which inactivate Sulfhydryl groups H + / K + -atf-Ase. Blocks the final stage of the secretion of HCl, reducing the content of basal and stimulated secretion, regardless of the nature of the stimulus. It has high lipophilicity, easily penetrates into stomach parietal cells and concentrates in them, having a cytoprotective effect and increasing the secretion of bicarbonate. The antisectory effect after oral administration 20 mg occurs for 1 hour and reaches a maximum after 2-4 hours; The inhibition of basal and stimulated food secretion of acid after 23 hours after taking the first dose is 62 and 82%, respectively, the duration of action is 48 hours. After receiving, secretory activity is normalized within 2-3 days. In the first 2-8 week of therapy, the concentration of gastrine in serum increases and returns to the original within 1-2 weeks after the cancellation. Does not affect the CNS, cardiovascular and respiratory system.

Pharmacokinetics:
Absorption is high, TCmax - 3.5 h. Cmax and AUC are linear in terms of doses range from 10 to 40 mg. Metabolized in the liver with the participation of Cytochrome Cyp2C9 and Cyp3a. Bioavailability - 52%, does not increase with repeated reception. T1 / 2 - 0.7-1.5 h, clearance - 283 ± 98 ml / min. In patients with hepatic insufficiency, AUC increases by 2 times, T1 / 2 - 2-3 times. Elderly patients with AUC increases 2 times, for 60%. Communication with plasma proteins is 97%. Examined by the kidneys - 90% in the form of 2 metabolites: Mercpturic acid conjugate (M5) and carboxylic acid (M6); through the intestines - 10%.

Indications:
Ulcerative disease of the stomach and 12-rosewood (treatment), gastroesophageal reflux disease, Zollinger-Ellison syndrome, stressful gastroy ulcers. In comprehensive therapy: Eradication Helicobacter pylori. in patients with ulcerative stomach and 12-rosewoman disease or chronic gastritis; Treatment and prevention of recurrence of peptic disease associated with Helicobacter Pylori.

Contraindications:
Hypersensitivity, pregnancy, lactation period. Caution. Children's age, severe renal failure.

Dosing mode:
Inside, 20 mg 1 time per day, in the morning. The course of treatment for ulcerative ulcer of the stomach and the 12-pans - 4-6 weeks, if necessary - up to 12 weeks; With reflux-esophagitis - 4-8 weeks. Tablets are swallowed entirely, not chewing and non-shred.

Side effects:
Nausea, constipation or diarrhea, abdominal pain, meteorism, headache, dizziness, drowsiness, weakness, skin rash, increase the activity of "liver" transaminases, thrombocytopenia, leukopenia; Pharyngitis, rhinitis, asthenia, back pain, influenza-like syndrome, Malgia, dry mouth mucous membrane, cramps of calf muscles, arthralgia, fever. Rarely - a decrease in appetite, an increase in body weight, depression, violation of vision or taste sensations, Stomatitis, increased sweating.

Special instructions:
Before and after treatment, endoscopic control is required to exclude malignant neoplasmbecause Treatment may disguise the symptoms and stop the correct diagnostics. The drug does not affect the function of the thyroid gland, the metabolism of carbohydrates, on the concentration in the blood of parathyroid hormone, cortisol, estrogen, testosterone, prolactin, cholecystokinin, secretine, glucagon, FSH, LH, Renin, aldosterone and somatotropic hormone.

Interaction:
Slows out the removal of some LS, metabolized in the liver by microsomal oxidation (diazepam, phenytoin, indirect anticoagulants). Reduces ketoconazole concentration by 33%, digoxin - by 22%.

Rabeprazole is an anti-sized agent from a group of proton pump inhibitors (H + / K + ATP-AZA).

It is an inhibitor of proton pump and blocks the final stage of acid products. This effect is dose-dependent and leads to the suppression of both basal and stimulated acid secretion, regardless of the stimulus. Does not have anticholinergic properties.

It has high lipophilicity, easily penetrates into stomach parietal cells and concentrates in them, having a cytoprotective effect and increasing the secretion of bicarbonate.

The antisecretory effect after oral administration 20 mg occurs within 1 hour and reaches a maximum after 2-4 hours. The inhibition of basal and stimulated food secretion of acid 23 hours after receiving the first dose is 62 and 82% appropriate, the duration of action is 48 hours.

After the end of the reception, secretory activity is normalized within 2-3 days. In the first 2-8 weeks of therapy, the concentration of gastrine in serum increases and returns to the initial levels within 1-2 weeks after the cancellation.

Does not affect the central nervous system (CNS), cardiovascular and respiratory system. Against the background of the preparation of the drug, stable changes in the morphological structure of enterochroma-like cells, into the degree of gastritis severity, in the frequency of atrophic gastritis, intestinal metaplasia or the dissemination of Helicobacter pylori infection is not detected.

At the beginning of therapy, the concentration of gastrine in the blood plasma increases, which is a reflection of the inhibitory effect on the secretion of hydrochloric acid. The concentration of gastrin returns to the initial level usually within 1-2 weeks after the cessation of treatment.

Indications for use

What does Rabeprazole help? According to the instructions, the drug is prescribed in the following cases:

• orately duodenal gut, among other things, at the stage of aggravation of the disease;
• pathological hypersecretion;
• gastroesophageal reflux disease;
• stomach ulcers;
• zolinger Ellison syndrome;
• gastritis (Eradication of Helicobacter Pylori), including chronic (jointly with antibacterial drugs);
• recurities of peptic diseases caused by Helicobacter Pylori.

Instructions for use RabnAzole, dosage

Inside, in the morning, before eating, not chewing and without grinding.

Standard dosages according to the instructions:

• with the ulcer of the stomach in the aggravation stage - Rabeprazole 20 mg \\ 1 times a day for 4 weeks, with insufficient healing - in addition for another 4 weeks;
• with a duodenal ulcer duel - 10 or 20 mg \\ 1 times a day for 6 weeks, with insufficient healing - another 6 weeks;
• with gastroesophageal reflux disease - Rabeprazole 20 mg \\ 1 time per day for 4-8 weeks, further supportive therapy is possible: 10-20 mg 1 time per day.

In the treatment of peptic disease or gastritis associated with Helicobacter pylori, it is appointed strictly as part of certain eradication schemes, 20 mg twice a day in combination with antibacterial drugs and, possibly, bismuth tricia dicyrate.

Due to various resistance to different antibiotics and genetic characteristics of the population in different territories, the eradication schemes are developed by national organizations.

Side effects

The instruction warns the possibility of developing the following side effects when appointing Rabeprazole:

• diarrhea, decreased appetite, stomatitis, vomiting and nausea, constipation, dryness of the oral mucosa, increase activity of hepatic transaminases, meteorism;
• dizziness, asthenia, drowsiness, violation of vision and taste receptors, headache,
• leukopenia, as well as thrombocytopenia;
• convulsions, myalgia, arthralgia;
• sinusitis, pharyngitis, cough and rhinitis;
• back pain;
• fever;
• allergic reaction in the form of rash.

Contraindications

Contraindicated to appoint Rabeprazole in the following cases:

• pregnancy and lactation (breastfeeding),
• increased sensitivity to slave sodium or substituted benzimidazoles.

Overdose

Symptoms of overdose - headaches and dizziness, nausea, vomiting, pain in the abdomen, constipation.

For treatment, symptomatic supporting therapy is applied. Dialysis is ineffective.

Analogs of Rabeprazole, price in pharmacies

If necessary, replaced Rabeprazole can be replaced by therapeutic action - these are drugs:

1. Omeprazole;
2. Omes;
3. Beret;
4. Pariet.

Choosing analogues It is important to understand that the instructions for the use of RabnAzole, the price and reviews for drugs of similar action do not apply. It is important to obtain a doctor's advice and not to produce an independent replacement of the drug.

Price in Pharmacies of Russia: Rabeprazole Capsules 20 mg 28 PCS - from 270 rubles, 10 mg - from 170 rubles, according to 740 pharmacies.

Store at a temperature of no more than 25c, the shelf life of 2 years. Vacation in pharmacies for the recipe.

Ulcerative ulcer of the stomach in the stage of exacerbation and anastomosis ulcer; Ulcent duodenal disease in the aggravation stage; Erosive and ulcerative gastroesophageal reflux disease (GERD) - adults and children from 12 years or reflux-esophagitis; Supporting therapy of gastroesophageal reflux disease; Non-erosive gastroesophageal reflux disease; Zolinger Ellison syndrome and other states characterized by pathological hypersecretion; In combination with appropriate antibacterial therapy for Helicobacter Pylori's eradication in patients with ulcerative disease.

Contraindications Rabeprazole-SZ Capsules 20mg

Hypersensitivity to Rabnazole, substituted benzimidazoles or to the auxiliary components of the drug; Sakaraz / isomaltase deficiency, fructose intolerance, glucose-galactose failure; pregnancy; breastfeeding period; Children's age up to 18 years old, with the exception of GERD (children under 12 years old).

Method of application and dosage Rabeprazole-SZ Capsules 20mg

Capsules of the drug Rabeprazole should be swallowed entirely. It has been established that nor the time of day, nor food intake affects the activity of Rabeprazole. With the ulcer of the stomach in the aggravation stage and the anastomosis ulcers. It is recommended to take inside of 10 mg or 20 mg once a day. Typically, the cure occurs after 6 weeks of therapy, but in some cases the duration of treatment can be increased by another 6 weeks. For ulcerative duel duodenal disease in the stage of exacerbation. It is recommended to take 20 mg inward once a day. In some cases therapeutic effect It occurs when taking 10 mg once a day. The duration of treatment is from 2 to 4 weeks. If necessary, the duration of treatment can be increased for another 4 weeks. In the treatment of erosive gastroesophageal reflux disease (GERD) or reflux-esophagitis, it is recommended to take inward 10 mg or 20 mg once a day. The duration of treatment is from 4 to 8 weeks. If necessary, the duration of treatment can be increased by another 8 weeks. With supporting therapy of gastroesophageal reflux disease (GERD), it is recommended to take on 10 mg or 20 mg once a day. The duration of treatment depends on the patient's condition. With non-erosive gastroesophageal reflux disease (NERB) without esophagitis, it is recommended to take inward 10 mg or 20 mg once a day. If after four weeks of treatment symptoms do not disappear, additional study of the patient should be carried out. After relieving the symptoms to prevent their subsequent occurrence, the drug should be taken inside at a dose of 10 mg once a day on demand. For the treatment of Zolinger-Ellison syndrome and other states characterized by pathological hypersecretion, the dose is selected individually. The initial dose is 60 mg per day, then the dose increases and prescribe a drug at a dose to 100 mg per day with a single reception or 60 mg twice a day. For some patients, fractional dosing of the drug is preferred. Treatment should continue as the clinical need. In some patients with Zolinger-Ellison syndrome, Rabeprazolese treatment was up to one year. For Eradication, Helicobacter pylori is recommended to take inside 20 mg 2 times a day according to a specific scheme with the appropriate combinations of antibiotics. The duration of treatment is 7 days. Patients with renal and liver failure. Dose correction to patients with renal failure is required. In patients with hepatic insufficiency of light and moderate severity, the concentration of Rabeprazole in the blood is usually higher than in healthy volunteers. When prescribing the drug Rabeprazole patients with a severe severity of hepatic insufficiency, caution should be taken. Elderly patients. Dose correction is not required. Children. Safety and efficiency of Rabeprazole 20 mg for short-term (up to 8 weeks) treatment GERB In children aged 12 years and more confirmed by the extrapolation of the results of adequate and well-controlled studies, supporting the efficiency of Rabeprazole for adults and safety and pharmacokinetics for childhood patients. The recommended dose for children aged 12 years and more is 20 mg 1 time per day for up to 8 weeks. The safety and efficacy of Rabeprazole for the treatment of GERD in children under the age of 12 is not installed. The safety and efficacy of Rabeprazole for use for other indications is not established for childhood patients.

Content

Tablets Rabeprazole

This drug is intended for people suffering from diseases of the gastrointestinal diseases. He has a large number of analogues, so you need to consult with a doctor who clarifies what specifically the patient is suitable. The drug has an impressive range of side effects and contraindications, so before use you need to weigh all the factors in order not to harm yourself.

Composition

One tablet tools comprises:

Pharmacodynamics and pharmacokinetics

Tablet Rabeprazole affects the enzyme H + -K + -atf-basic, produced in the parietal cells of the esophagus. He acts as a proton pump inhibitor. The resulting compound blocks the formation of hydrochloric acid at the final stage and lowers the level of stimulation of secretion, regardless of the type of stimulus. After receiving 20 mg, the preparation is completely absorbed after 3.5-4 hours. Taking time does not affect the bioavailability of the main connection and its absorption properties.

Indications for use

The drug is prescribed if the patient diagnosed the following diseases:

• Duodenal ulcer.
• Recognition of ulcerative disease provoked by the Bacteria Helicobacter Pylory (Helicobacter Pylory).
• Pathological hypersecretion.
• Gastritis (Helicobacter Pylorus Eradication), including chronic gastritis (using antibacterial drugs).
• Gastroesophageal reflux disease.
• Syndrome Zlinger Ellison.
• Ulcer stomach.

Instructions for the use of Rabeprazole

Capsules with the active substance must be used inside. Taking time does not affect anything, as well as eating before or after. The dosage of the drug and the frequency of use is completely dependent on the severity of the disease, the instructions of the specialist. Initial dose for patients with standard disease symptoms - 10 or 20 mg times per day. Treatment lasts two months (6 weeks). If the proper effect did not follow - the treatment is extended to the same.

special instructions

The presence of malignant formations of the gastrointestinal formation should be eliminated, since the drug is characterized by the property of masking symptoms of oncology, which will complicate the diagnosis and timely detection oncological diseases. With violations of the liver functions, the drug should be taken very carefully. Change the dosage of digoxin and ketonazole, the drug Rabeprazole does not allow them to be used as standard dosage. If your work requires a high concentration of attention or you drive transport - eliminate these actions if the drug causes drowsiness or fatigue.

During pregnancy

Official data on whether it is possible to apply the drug during pregnancy, no. Animal research did not show problems with the development of the fetus, but rats a small dose overcame the placental barrier, so the use during pregnancy should be carried out strictly under the control of the doctor. Similar situation with lactation: medicine It falls into the milk, so during lactation it should not be used.

In childhood

It is forbidden to 18 years. The exception is GERD (gastroesophageal reflux disease) in children from 12 years. Studies have not proven absolute efficacy and safety for children with GERD. Efficiency for children who take the drug for other reasons, the research does not indicate, but the recommended dose that doctors are prescribed - 20 mg once a day for eight weeks.

Medicinal interaction

The main active ingredient absolutely does not interact with the antacids (type of drugs used to combat acid-dependent gastrointestinal diseases), but can affect the saturation of the blood plasma by ketoconazole or digoxin. For parallel use, diazepams, phenytoin, warfarin or theophylline are fully suitable. As a last resort, the drug can be used together with the proton pump inhibitor Pantoprazole. If this drug is specified in the list, check the dosage from the doctor.

Rabeprazole and alcohol

Alcohol use is strictly prohibited. Double liver load can aggravate the condition. The risk of occurrence of side effects will increase. Even excluding the drug itself, alcohol is invalid during the period of peptic diseases and leads to exacerbations. The use of beer is also banned.

Side effects and overdose

The use of the drug may cause disorders of the gastrointestinal tract, musculoskeletal system, nervous and respiratory systems. Among side effects:

• Allergic reaction, rash.
• Diarrhea.
• Reduced appetite, flatulence.
• Stomatitis, increasing the activity of hepatic transaminases.
• Vomiting and nausea, dry mucosa, constipation.
• Fever.
• Dizziness, asthenia.
• Influencing syndrome.
• Drowsiness, thrombocytopenia.
• Violation of vision, taste receptors.
• Leukopenia, headache.
• High fatigue.
• Back pain.
• Cramps, arthralgia, Malgy.
• Sinusitis, cough, pharyngitis, rhinitis.
• Stevenson-Jones syndrome.

Contraindications

It is strictly forbidden to take the drug during pregnancy or lactation. It is impossible to use in individual intolerance or hypersensitivity to certain components of the drug (Barpazole or substituted benzimidazole). Do not use with sugar deficiency, fructose intolerance or glucose-galactose failure. If you have severe renal or liver failure, the drug is also contraindicated.

Terms for sale and storage

The drug is stored at room temperature (not higher than 25 degrees Celsius), should be protected from moisture and direct ingress of sunlight. At the end of the shelf life is prohibited.

Analogs

Analogs of Rabeprazole is a wide range of drugs. The cost of analogs exceeds the cost of the original twice, if not more. From major competitors (in chemical composition The main active ingredient is not indicated):

• Omeprazole. Manufacturer - Ukraine, Russia, Israel, Hungary. The composition is almost identical. Release form - 20 mg capsules. The average cost - from 28 rubles per pack.
• Noflux. Manufacturer - Hungary. Composition - magnesium oxide, mannitol, etc. Release form - Tablets at 10, 20 mg. The average cost - from 828 to 1296 rubles per pack.
• Highurezol. Manufacturer - India. The composition is magnesium oxide, mannitol, corn crumbmal. Release form - Tablets at 10, 20 mg. The average cost - from 368 rubles.
• Zulbex. Manufacturer - Slovenia. The composition is mannitol, magnesium oxide, hypolosis. Release form - Tablets at 10, 20 mg. The average cost - 315 rubles.
• Ontym. Manufacturer - "Teva", Russia. The composition is low-substituted hypolosis, magnesium oxide, mannitol. Release form - Tablets at 10, 20 mg. The average cost - from 577 rubles.

Pills.ru.

Rabeprazole-SZ Capsules intestinal-soluble 10 mg 14 pcs.

Rabeprazole-SZ Capsules intestinal-soluble 20 mg 14 pcs.

Eaktec.ru.

Parity tablets 20 mg 14 pcs.

Aptekamos.ru.

Tablets 10 mg

Beret pills 20 mg