The medicinal product of Italian origin with bizarre at first glance the name "Vessel Due F" is a natural substance obtained from the mucous membrane fine intestine Pig. This is a natural "mix" Mukopolisaccharides, 80% of which is the heparin-like fraction, and the remaining 20% \u200b\u200bdermatansulfate. pharmachologic effect This drug (and its international non-proprietary name sounds like Sulodexin), one way or another is associated with blood and vessels and is consistent with the summation of the finiginalitic (the ability to split fibrin, which is the basis of blood clots), antithrombotic (everything is clear), angioprotective (decrease in the permeability of vessel walls) and anticoagulant (prevent blood clotting) effects. The fast-flowing heparin-like fraction nourishes "related feelings" to antithrombin III, and dermatanova, in turn, has affinity for the Heparin II cofactor, which "disarms" the most important ingredient Blood coagulation systems - thrombin. Such, if described in a nutshell, the mechanism of anticoagulant action Vessel Due F. It develops due to the activation of the formation and release of prostacyclin (PGI2), a decrease in fibrinogen's blood concentration, inhibiting the activated X factor, etc. Determined by an increase in the blood content of plasminogen - the predecessor of the fabric activator of the plasmin, as well as the simultaneous decrease in the level of its inhibitor.

An angioprotective effect of the drug is consisted of the regeneration of the morphological and functional integrity of endothelial vascular cells, normalizing the negative charges of pores of the basal vascular membranes. Additionally, the blood flow rate increases due to the reduction of triglyceride content (the drug activates the enzyme lipoproteinlipase, splitting triglycerides, which are included in the "bad" cholesterol). Thanks to its purely positive influence On the vascular channel, the drug finds use when various diseases Blood vessels of any localization, circulatory disorders, incl. caused by diabetes.

Vessel Due F is produced in two dosage forms: Capsules and a solution for injecting administration. The solution is introduced both intramuscularly and intravenously (in the latter case, together with 150-200 ml of saline). At the beginning of the drug course for 15-20 days, 1 ampoule of the drug is used daily, then a transition to oral shape with a multiplication of reception 2 times a day is 1 capsule between the meals for 30-40 days. A full course of treatment must be repeated with periodicity at least 2 times a year. The attending physician may, at its discretion, change the dosing mode of the drug.

Pharmacology

Anticoagulant, heparinoid. It has antiagregative, antithrombotic, angioprotective, hypolypidemic and fibrinolytic effect. The active substance is an extract from the mucous membrane of the small intestine of animals, is a natural mixture of a fast-lived heparin-like fraction (80%) and dermatantium sulfate (20%). Suppresses the activated factor X, enhances the synthesis and secretion of prostacyclin (PGI2 prostaglandin), reduces the concentration of fibrinogen in the plasma. Increases the concentration of the activator of the tissue profibrinolysine (plasminogen) in the blood and reduces the concentration in the blood of its inhibitor.

The mechanism of angioprotective action is associated with the restoration of the structural and functional integrity of the cells of the endothelium of the vessels, as well as the normal density of the negative electrical charge of the pores of the basal membrane of the vessels. Normalizes the rheological properties of blood by reducing TG and reduce blood viscosity.

The effectiveness of the application is diabetic nephropathy Determined by a decrease in the thickness of the basal membrane and a decrease in the production of matrix by reducing the proliferation of Mesangium cells. When in / in the introduction in high doses, its anticoagulant action is manifested due to the inhibition of the HEPARIN COFACTOR II.

Form release

The solution for V / B and V / M introduction of light yellow or yellow color, transparent.

Auxiliary substances: sodium chloride, water d / and.

2 ml - dark glass ampoules with a volume of 2 ml (10) - packs cardboard.

* - Lipoproteinlipasna unit.

Dosage

Individual, depending on the clinical situation.

Side effects

From side digestive system: Nausea, vomiting, pain in the epigastric area.

Others: skin rash; At the injection site - pain, burning, hematoma.

Indications

Angiopathy with increased risk of thrombosis (incl. After the myocardial infarction); Violation brain circulation (including an acute period of ischemic stroke and early recovery period); Discirculatory encephalopathy due to atherosclerosis, diabetes, arterial hypertension; vascular dementia; occlusal lesions of peripheral arteries (including atherosclerotic and diabetic genesis); phlebopathy, deep veins thrombosis; microangiopathy (nephropathy, retinopathy, neuropathy) and macroangiopathy sugar diabetes (diabetic foot syndrome, encephalopathy, cardiopathy); thrombotic states, antiphospholipid syndrome (as part of combined therapy with acetylsalicylic acid); To continue therapy with the development of heparinnidulated thrombotic thrombocytopenia.

1 capsule contains a mixture of ethyl esters of linoleic and linolenic acids 250 mg; Packaging 24 pcs.

1 g of ointment oily or bold - 20 mg; in tubes for 55 g

pharmachologic effect

Increases the formation of GHGs, normalizes the functions of the liver and the gastrointestinal tract, increases blood pressure, renal blood flow, prevents the excess deposition of cholesterol in tissues and slows down the sclerosis, promotes healing wounds and ulcers.

Drug testimony Vitamin F99

Capsules: Eczema (Seborin, Children's, Milk Strap), Liver Diseases, Digestion Disorders.

Fat ointment: dry eczema, sensitive painful skin, skin cracks, ulceration, cuts, surface burns.

Bold ointment: weakening eczema, milk paper, surface burns, cuts, varicose spikes, furunculosis.

Contraindications

Hypersensitivity (including to individual components, the obturation of biliary tract and calculous cholecystitis (capsules).

Side effects

No detected.

Method of application and dose

Inside, externally.

Capsules (before meals, not chewing): Adults - in the middle daily dose of 3-6 caps. (no more than 8 caps.); Children, incl. Teenagers - 1-2 caps. (no more than 4 caps.).

Ointment applies to a purified affected surface and the skin with a layer of 1-2 mm 2 times a day; If necessary, impose a bandage.

Precautions

It is necessary to avoid falling ointment into the eyes and on the mucous membranes.

Conditions for the storage of the drug Vitamin F99

Keep out of the reach of children.

The shelf life of Vitamin F99

Do not apply after the expiration date indicated on the package.

Synonyms of nosological groups

URONORMIN-F: Instructions for use and reviews

In ophthalmology, drugs are often used for local application. Eye drops can have a different appearance and purpose. So, drugs produce anti-inflammatory, vasoconstrictor, moisturizing or antimicrobial effect. Lower popularity have painkillers. One of these is the preparation "Diclo F" (Eye drops). Instructions for use of this fund will be described below. From the article you will also learn about the reviews that the medication has.

general description

Medicine "Diclo F" - Eye drops. Instructions for use reports that they are intended for local use. The drug includes an active ingredient, its number of 1 millilitress of drugs is 0.1 milligrams.

The preparation includes additional components: Dinatari Edetat, boric acid, Trometamine, castor oil and water for injection. Eye drops of "Diclo F 0.1%" in the amount of 5 milliliters are produced. The solution is placed in plastic packaging-dropper. Instructions for use are present in each pack. Store the tool is needed out of the reach of children. The ambient temperature should not exceed 30 degrees. At the same time, it is not at all be sure to place the medicine in the refrigerator. Use cold drops, according to patient reviews, not very nice. After the expiration date, the medicine is not allowed.

How can I replace the medication?

Does "Diclo F" (eye drops) analogues? Currently, such drugs with the same existing substance have a lot. Among them, they present drugs "Diklogen", "Voltaren OFTT", "Diklak", "Diclofenak" and so on.

If we talk about the method of application, then among the analogs it is possible to allocate "Albucid", "visiting", "Tobradex", "dexamethasone" and so on. All of them can have other readings to use. That is why the analogue of one or another drug must be chosen along with a specialist.

Purpose

The drug "Diclo F" (Eye Drops) Instructions for use advises to use only to appoint a doctor. It has the following testimony:

• cataract operation (the need to inhibit my andos);
• prevention or treatment inflammatory processeswho have been a consequence of operational intervention;
• cystic edema and its prevention;
• conjunctivitis of non-infectious origin;
• the injury of the eyeball (as symptomatic therapy).

The drug "Diclo F" has a local anti-inflammatory, anesthetic and antipyretic effect.

Information that needs to be taken into account

Before using the diclo f (eye drops) medication, it is necessary to study contraindications. Even if the medication is assigned to an ophthalmologist, you need to read the instructions. If you have one or more contraindications, never apply the preparation described. Contact your doctor and tell about your situation.

Medicine "Diclo F" is not assigned to increased sensitivity to diclofenac or any other component included in its composition. It is not used in some blood diseases. With extreme caution use medicine for the treatment of older people and patients with inflammatory diseases digestive tract. The medicine does not apply during the wearing contact lenses. The use of drops during pregnancy and breastfeeding is also prohibited.

"Diclo F", Eye Drops: Instructions for use

Depending on the testimony, the medication may have a different application scheme. So, to inhibit my hair and expanding the pupil, it is necessary to start using two hours before the operation. At the same time, four administrations of the medication in a conjunctival bag with an interval of about thirty minutes are made.

If it is necessary to make prevention of cystic edema "Diclo F" (eye drops), instructions for use recommends to enter one drop to four times a day. The duration of application is determined by the doctor, depending on the outcome of the operation. If a specialist does not give individual appointments, then the drops are used for two weeks.

As an anti-inflammatory or anesthetic drug, the drug is used for one or two weeks 2-4 times a day.

Reactions to therapy

About the preparation "Diclo F" (Eye Drops) Instructions for use informs that it has adverse reactions. Unwanted effects arise quite rarely with proper use. However, if you encountered them, you need to seek an ophthalmologist as soon as possible to correct therapy.

Immediately after the instillation, the drug may cause burning, itching, clouding of the cornea and an ambiguity of view. Less often occur swelling and redness, urticaria. The medicine during improper use and use inside can cause nausea, diarrhea and abdominal pain. Treatment of adverse reactions is usually not required. They pass after the cancellation of the medication. Exceptions are only heavy allergic conditions.

"Diclo F" (eye drops): reviews

Most patients who accounted for this drug remained satisfied with the result. In rare cases, adverse reactions were recorded and treatment was needed.

Consumers report that immediately after installation can be easy sensations. The same arise when in the eye of ordinary water. However, after a few seconds, such symptoms pass. Some consumers mark chill or, on the contrary, warm in the area of \u200b\u200bthe eye after instillation. This situation is not a side effect and does not require discontinuation of therapy.

When using the drug in prophylactic purposes, it shows positive results. Application Before the operation avoids the occurrence of a mine, which may affect the course of the procedure and aggravate the patient's condition.

Consumers suggest that the Diclo F's medicine is inexpensive and affordable almost all of the segments of the population. At the same time, it shows good results of treatment and prevention and can be combined with many medicines. Therefore, it is often prescribed for the treatment of conjunctivitis as a symptomatic agent.

Doctors remind that the break between the application of different medicines The area of \u200b\u200borgans should be at least half an hour. Otherwise, an unexpected reaction to mixing preparations may occur. Also, ophthalmologists advise on the time of therapy to stop wearing contact lenses. Some materials can deteriorate under the action of diclofenac. Give preference to ordinary points.

Experts suggest that during the installation of the medication it is impossible to touch the pipette to the mucous membrane of the eye. It is recommended to store it after opening no more than one month.

Let's summarize the article

You learned about an anesthetic drug, which can also take inflammation. He has tradename "Diclo F". Eye dropsThe instruction to which you are presented to your attention can be purchased almost in any pharmacy. Some pharmacists require a recipe when selling. Therefore, it is necessary to take care of his receipt of the doctor in advance. The cost of the medication is available. You can buy one pack of drops about one hundred and fifty rubles. The price can slightly move in one direction or the other. Therefore, find out the details in a particular pharmacy. Much depends on the trading charge.

Do not use the medication without appointing a doctor. Be sure to read the annotation, paying attention to the testimony and contraindications. Do not exceed the dose prescribed to you. With proper use of the drug, the positive effect is already noted immediately. All are good, do not get sick!

This article allows you to familiarize yourself with the instructions for use. medicinal preparation Eskinor F.. Reviews of site visitors - consumers of this medicine, as well as the opinions of doctors of specialists in the use of Eskinor F in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effectsmay not be stated by the manufacturer in annotations. Analogs of Eskinur F in the presence of available structural analogues. The use of hormonal contraceptive for emergency postcoital contraception (after sexual intercourse) in women. The composition and side effects of the drug.

Eskinor F. - This is a synthetic gestagen with contraceptive action, pronounced by gestagenic and anti-estrogenic properties. With the recommended dosing mode, the Levonorgestrel (the active substance of the drug Escynor f suppresses ovulation and fertilization, if the sexual contact occurred in the pre-deputy phase, when the possibility of fertilization is the largest. It may also cause changes in endometrials that prevent implantation. Increases the viscosity of the cervical mucus, which prevents the viscosity of the cervical mucus . The drug is not effective if implantation has already occurred.

Reception of Eskinor F is recommended to start as soon as possible (but no later than 72 hours) after sexual intercourse, if no applied protective measures Contraception. The longer the time passed between the sexual act and the reception of the drug, the lower its efficiency (95% for the first 24 hours, 85% - from 24 to 48 hours, and 58% from 48 to 72 hours).

Composition

Levonorgestrel + excipients.

Pharmacokinetics

When orally admission, the levonorgestrel is quickly and almost completely absorbed. Absolute bioavailability is 100% of the adopted dose. After receiving 1 tablet, the Essinor F maximum concentration of the levonorestrel in serum is achieved after 1.6 hours. The levonorgestrel is associated with albumin serum and with globulin, binding sex hormones (GSPG). Only 1.5% of the entire dose is in free form, and 65% is connected with the GSPG. The drug penetrates breast milk. The levonorgestrel is hydroxylated in the liver, metabolites are derived in the form of conjugated glucuronides. Pharmacologically active metabolites of Levonorgestrel are unknown. The levonorgestrel is derived approximately equally to the kidneys and through the intestines exclusively in the form of metabolites.

Indications

• emergency (postcoital) contraception (after unprotected sexual intercourse or unreliability of the method of contraception used).

Forms of release

Tablets 0.75 mg and 1.5 mg.

Instructions for use and dosing mode

The drug is accepted inside. Escynor F can be applied at any time. menstrual cycle. In the case of an irregular menstrual cycle, pregnancy must be preliminary.

After receiving an emergency contraceptive to the onset of the next menstruation, local barrier contraceptives should be applied (for example, a condom, cervical cap). The use of the drug with a re-unprotected sexual intercourse during one menstrual cycle is not recommended due to an increase in the frequency of acyclic bleeding / bleeding.

Tablets Escynor F 1,5 mg

It is necessary to take 1 tablet as soon as possible, but no later than 72 hours, after unprotected intercourse. If within 3 hours after receiving the tablet, the Esquinor F 1,5 mg occurred, it should be taken another 1 tablet Escynor F 1,5 mg.

Tablets Escynor F 0.75 mg

It is necessary to take 2 tablets and no later than 72 hours after unprotected intercourse, while the second tablet should be taken after 12 hours (but not later than after 16 hours) after receiving the first tablet.

To achieve a more reliable effect, both tablets should be taken as quickly after unprotected sexual intercourse (no later than 72 hours). If within 3 hours after the reception of the first or second tablet, the Escinkor F 0.75 mg occurred vomiting, then another 1 tablet Escynger f 0.75 mg should be taken.

Pdurability

• nausea, vomiting;
• fatigue;
• pain at the bottom of the abdomen;
• acyclic bloody issues (bleeding);
• diarrhea;
• dizziness, headache;
• disease soreness;
• menstruation delay (no more than 5-7 days). If menstruation does not occur for a longer period, it is necessary to exclude pregnancy;
• allergic reactions: urticaria, rash, itching, swelling of the face.

Contraindications

• children's age up to 16 years;
• severe liver failure;
• pregnancy, including the estimated;
• lactation period (breastfeeding);
• rare hereditary diseases, such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption (due to the presence of lactose in the preparation);
• increased sensitivity to levonorgestrel or any other component of the drug.

Application in pregnancy and breastfeeding

Escyno F cannot be applied during pregnancy. If the pregnancy originated when applying an emergency method of contraception, then on the basis of the existing data of the adverse effect of the drug, the fruit is not expected.

Levonorgestrel penetrates maternal milk. After taking the drug, breastfeeding should be stopped for 24 hours.

Application in children

Contraindicated B. childhood up to 16 years.

In adolescents under 16, the use of the drug Eskinor F is only possible in exceptional cases (including with rape) and only after consulting the gynecologist. After emergency contraception, a re-consultation of the gynecologist is recommended.

special instructions

Escynor F should be used exclusively for emergency contraception.

Repeated use of the drug Esquinor F for one menstrual cycle is not recommended.

The medicine should be accepted as soon as possible, but no later than 72 hours, after unprotected intercourse. The effectiveness of emergency contraception during the delayed use of the drug is significantly reduced.

The drug does not replace the use of permanent methods of contraception.

In most cases, Escynor F does not affect the nature of the menstrual cycle. However, the appearance of acyclic bleeding and latency of menstruation for several days is possible. When menstruation delay is more than 5-7 days and change its character (scanty or abundant discharge) It is necessary to exclude pregnancy. The appearance of pain at thenime of the abdomen, fainting may indicate an ectopic (ectopic) pregnancy.

Emergency contraception does not protect against sexually transmitted diseases.

For diseases of the gastrointestinal tact (gastrointestinal tract), for example, with crown disease, the efficacy of the drug may decrease.

Impact on the ability to driving vehicles and control mechanisms

The effect of the drug ESKINOR F to control the car and other machines has not been investigated. In the event of dizziness development, you should refrain from driving vehicles and classes requiring increased concentration and speed of psychomotor reactions.

Medicinal interaction

With simultaneous reception of drugs of inductors of microsomal liver enzymes, the metabolism of the Levonorggestrel is accelerated.

Reduce the effectiveness of Esquiner F can Amprenavir, Lansoprazole, Nevirapin, Okskarbazepine, Tharolimus, Topiramat, Trertinoin, Barbiturates (including Prison), Phenitoin and Carbamazepine, preparations containing John's jacket (Hypericum Perforatum), as well as rifampicin, rhythonavir, ampicillin, tetracycline, rifabutin , Griefullvin.

ESKINOR F reduces the effectiveness of hypoglycemic and anticoagulant (derivatives of Kumarin, Phoenindion) medicines.

Levonorgestrel increases plasma concentrations of glucocorticosteroids (GKS). Women taking these drugs should consult a doctor.

Preparations containing levonorgestrel can increase the risk of cyclosporine toxicity, due to the suppression of its metabolism.

Analogs of the drug Eskinor F

Structural analogues for the acting substance:

• Levonorgestrel;
• Model 911;
• Microli;
• Miren;
• Norplant;
• Postinor;
• Escapel.

Analogs of the drug therapeutic effect (contraceptive):

• Angelty;
• Anteovine;
• Acetomepregenol;
• Belarus;
• Benatex;
• Bonade;
• Gestrell;
• Gynecotex;
• Hyneproviston;
• Delusa;
• Demlen;
• Jess;
• Dimia;
• Jera;
• Zhanin;
• Feminine;
• Seven;
• Zoeli;
• Clair;
• Contraceptor T;
• Lactinet;
• Lindinet;
• Load;
• Marvelon;
• Mercylon;
• Midian;
• Microjinon;
• Microli;
• Miniziston;
• Mellel;
• Miren;
• Model;
• National;
• New one;
• Non-lounge;
• Norcut;
• Norplant;
• Omdon;
• Oralkone;
• Postinor;
• Regular;
• Riguevidon;
• Silest;
• Silica;
• Sterilin;
• Three regrol;
• Trigestrel;
• Trocilar;
• Pharmatex;
• Femisse Messi;
• Femoden;
• Chloride;
• Egstrenol;
• EXLUTON;
• Erica 35;
• Escapel;
• Yarina;
• Yarina Plus.

Review of the gynecologist's doctor

In general, the drug Eskinor F is a good and effective contraceptive, but provided it is properly used. The adverse reactions to it are rarely developed, but again, subject to instructions for use. This rule, unfortunately, not always and not all women follow. Especially often young girls are addressed to me with complaints about bleeding or even bleeding from sex tract in the middle of the menstrual cycle. During the question, it turns out that the girls took the Eskinor-F tablets not one time per month. This was the cause of hormonal disorders. It is impossible to relate to the use of hormone contraceptives in no case, which I always warn my patients.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.