Non-corrugated funds.

Composition of coofamis

Caffeine, Ergotamine.

Manufacturers

TatchimFarPreparations (Russia)

pharmachologic effect

Combined drug.

Caffeine causes the stimulation of the CNS, mainly the cortex of the brain, respiratory and vascular centers.

Enhances mental and physical performance, reduces drowsiness, feeling fatigue.

It has a pronounced cardiotonic effect:

• increases the power and frequency of heartbroction,
• increases blood pressure under hypotension.

Ergotamine causes a vesseloring effect.

Caffeine accelerates Ergotamine suction.

Side effect of coofamine

From side nervous system:

• arousal, anxiety, tremor, anxiety, headache, dizziness, cramps, paresthesia in limbs, reinforcement of reflexes, tachipne, insomnia;
• in case of sudden cancellation, the increase in the braking of the CNS, increased fatigue, drowsiness.

From the side of the SCC:

• heartbeat
• tachycardi,
• cardialias
• increased blood pressure

From side digestive system:

• nausea
• vomit
• diarrhea.

Allergic reactions:

• edema,
• skin itch.

Others:

• for long use - Accustomed
• drug dependency
• weakness in the leg
• malgi,
• lerish syndrome (sharp cyano,
• lack of pulse on the lower limbs,
• violation of sensitivity to distal type).

Indications for use

Migraine, arterial hypotension.

Contraindications of coofamine

Hypersensitivity, pregnancy, lactation period.

Carefully:

• disorders
• alarming disorders (agorafobi,
• panic disorders,
• organic diseases SCC (including acute myocardial infarction,
• angina
• expressed atherosclero
• paroxysmal tachycardi,
• frequent ventricular extrasystoles,
• arterial hypertension,
• irradizing diseases of peripheral vessels,
• hepatic and / or renal failure,
• glaucoma
• elderly age.

Method of application and dosage

Inside, 1-2 tablets on the reception during the attack of headaches, then 1 tablet 2-3 times a day for several days.

Maximum motherwise dose - 2 tablets, daily - 4 tablets.

• after 7 days of use in case
• requiring longer treatment,
• make a break (for 3-4 days).

Overdose

Symptoms:

• strengthening the severity of side effects
• including nausea
• vomit
• numbness in the fingers of the hands and but
• inhibitory
• sleep,
• epileptic seizure
• foot,
• coma.

Treatment:

• stomaching,
• acceptance of activated angle
• if necessary, the conduct of symptomatic therapy.

Interaction

Strengthens pharmachologic effect Dr.

Caffeine is adenosine antagonist.

With the joint use of caffeine and barbiturates, a prison, anticonvulsant drugs (Derivatives of Hydanoin, especially phenytoin), it is possible to strengthen the metabolism and an increase in caffeine clearance; Cimetidine, oral contraceptive drugs, disulfirama, ciprofloxacin, norfloxacin - decrease in caffeine metabolism in the liver.

Means causing the stimulation of the central nervous system are excessive stimulation of the CNS.

Mexylene reduces caffeine removal up to 50%; Nicotine increases the rate of caffeine.

Inhibitors of Mao, Faurazolidon, Procarbazin and SELEGILIN - large doses of caffeine can cause the development of dangerous heart arrhythmias or pronounced blood pressure.

Caffeine reduces the absorption of CA2 + drugs in the gastrointestinal tract.

Reduces the effect of narcotic analgesics and sleeping pills; Increases - non-nucleic analgesics.

Increases the removal of Li + preparations with urine.

Accelerates suction and enhances the effect of cardiac glycosides, increases their toxicity.

Sharing caffeine with beta adrenoblockers and can lead to a mutual suppression of therapeutic effects; With adrenergic bronighting ls - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine can reduce theophylline clearance and, possibly, dr. Xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.

The vesseloring effect of the drug amplifies the alpha-adrenostimulants, beta-adrenobloclars, serotonin agonists (including Sumatapan) and nicotine.

Macrolids increase ergotamine toxicity.

Active substances: Caffeine - 100 mg and ergotamine Tartrate - 1mg;
Excipients: Auxiliary substances: starch potato, talc, stearic acid, sucrose, dextrose.

Description

Pills covered with shell, white, bico shape. Two layers are visible on the cross section: white-colored shell, white or white core with a creamy colors.

Pharmacotherapeutic group

Anti-graded agent.

Pharmacological properties

Combined drug. Caffeine causes the stimulation of the central nervous system, mainly the cortex of the brain, respiratory and vascular centers. Enhances mental and physical performance, reduces drowsiness, feeling fatigue. It has a pronounced cardiotonic effect: increases the strength and frequency of heart cuts, increases blood pressure during hypotension. Ergotamine causes a vesseloring effect. Caffeine accelerates Ergotamine suction.

After taking orally, about 62% of ergotamine is absorbed in the gastrointestinal tract.
The maximum plasma concentration is achieved 2 hours after receiving inside. Binding with plasma proteins is 98%. Ergotamine is metabolized in the liver with the formation of pharmacologically active metoboliths. Ergotamine is excreted mainly with bile both in constant form and in the form of metabolites. The removal is two-phase character, half-life of 2.7 h and 21 h for the I and II phase, respectively.
After taking the drug inside the caffeine is absorbed quickly and almost completely. Binding with plasma proteins is 35%. Caffeine is almost completely metabolized in the body. Metabolites are output mainly with urine. The half-life is about 3.5 hours.

Indications for use

Migraine, headache against the background of the arterial hypotension.

Contraindications

Individual intolerance to the components of the drug, pregnancy, lactation period.
With caution - sleep disorders, disturbing disorders, organic diseases of the cardiovascular system (including acute myocardial infarction, angina, expressed atherosclerosis, paroxysmal tachycardia, frequent ventricular extrasystole, arterial hypertensionSupporting peripheral vessels), hepatic and / or renal failure, glaucoma, elderly age.

Method of application and dosage

Inside, 1-2 tablets during the attack of headaches, then 1 tablet 2-3 times a day for several days. Maximum single dose - 2 tablets, daily -4 pills.
It is not recommended to use for a long time (avoiding the phenomenon of ergotism): after 7 days of application in cases requiring longer treatment, take a break (for 3-4 days).

Side effect

From the nervous system: excitation, anxiety, tremor, anxiety, headache, dizziness, cramps, paresthesias in the limbs, increase tendon reflexes, tachipne, insomnia; In case of sudden cancellation, an increase in the braking of the central nervous system, increased fatigue, drowsiness.
From the side of the cardiovascular system: tachycardia, cardialgy, an increase in blood pressure.
From the digestive system: nausea, vomiting, diarrhea.
Allergic reactions: swelling, skin itch.
Others: With prolonged use - addiction, drug addiction, weakness in the legs, Malgy, Lerish syndrome (sharp cyanosis, no pulse on lower limbs, pain, distillation violation of distal type).

Overdose

Symptoms: Enhancement of severity side Effects, including nausea, vomiting, numbness of fingers and legs, inhibition, drowsiness, epileptic seizures, stupor, coma. Treatment: washing the stomach, the reception of activated carbon, if necessary, the conduct of symptomatic therapy.

Interaction with other medicines

Enhances the pharmacological effect of drugs containing alkaloids of the ardines and caffeine.
Caffeine is an adenosine antagonist (large doses of adenosine may be required).
With the joint use of caffeine and barbiturates, prison, anticonvulsants (Derivatives of Gidantoin, especially phenytoin), it is possible to strengthen the metabolism and an increase in caffeine clearance; Cimetidine, oral contraceptives, disulfyrama, ciprofloxacin, norfloxacin - decrease in the metabolism of caffeine in the liver (slowing down its selection and an increase in blood concentration).
Means causing the stimulation of the central nervous system - an excessive stimulation of the central nervous system is possible.
Mexyleletin - reduces caffeine allocation to 50%; Nicotine - increases the rate of caffeine.
Inhibitors of Mao, Furazolidon, Zamarbazin and Selegylin - large doses of caffeine can cause the development of hazardous heart arrhythmias or a pronounced blood pressure.
Caffeine reduces the suction of calcium preparations in the gastrointestinal tract. Reduces the effect of narcotic and sleeping pills; Enhances nonarcotic analgesics (increasing suction). Increases removal of lithium drugs with urine.
Accelerates suction and enhances the effect of cardiac glycosides, increases their toxicity.
The joint use of caffeine with beta-adrenoblockers can lead to a mutual suppression of therapeutic effects: with adrenergic bronchorated means - additional stimulation of the central nervous system and other additive toxic effects.
Caffeine can reduce theophylline clearance and, possibly, other xanthines, increasing the possibility of additive pharmacodynamic and toxic effects. The vesseloring effect of the drug amplifies alpha-adrenostimulants, beta-adrenoblays, serotonin agonists (including Sumatapan) and Nicotine. Macrolids increase the toxicity of ergotamine (decreased by the liver clearance of caffeine).

Cofetamine: Application Instructions and Reviews

Combined drug whose action is determined by the components included in its composition. Caffeine causes the stimulation of the central nervous system, mainly the cortex of the brain, respiratory and vasomotory centers. Enhances mental and physical performance, reduces drowsiness, feeling fatigue. It has a pronounced cardiotonic effect: increases the strength and frequency of heart cuts, increases blood pressure during hypotension. Ergotamine causes a vesseloring effect. Caffeine accelerates Ergotamine suction.

Cofetamine Instructions for use

International name - Caffeine + Ergotamine (Caffeine + Ergotamine.).
Tradename - ( Coffetamin.).

Forms of release and composition

Tablets Cofetamine, coated. 1 Tablet Contains: Caffeine 100 mg, ergotamine Tartrate 1 mg. In the packs of contour cells or test tubes of 10 pcs. In a pack of cardboard 1 or 2 packs or 1 test tube.

Pharmacological group

Anti-graded agent.

pharmachologic effect

• vasoconstrictor
• non-corrugated

Pharmacokinetics

After taking orally, about 62% of ergotamine is absorbed in the gastrointestinal tract. The maximum plasma concentration is achieved 2 hours after receiving inside. Binding with plasma proteins is 98%. Ergotamine is metabolized in the liver with the formation of pharmacologically active metabolites. Ergotamine is excreted mainly with bile both in constant form and in the form of metabolites. The removal is two-phase character, half-life of 2.7 h and 21 h for the I and II phase, respectively. After taking the drug inside the caffeine is absorbed quickly and almost completely. Binding with plasma proteins is 35%. Caffeine is almost completely metabolized in the body. Metabolites are output mainly with urine. The half-life is about 3.5 hours.

Indications for the use of coffee

Card-brain hypertension (vascular, traumatic and infectious genesis), migraine, arterial hypotension.

• Hypotensive syndrome in mother
• Hypotension
• Hypotension
• Drug hypotension
• Hypertensive Encephalopathy
• Anoral blood pressure indicators in the absence of a diagnosis
• Intracranial hypertension after the shunting of ventricles
• Idiopathic hypotension
• Disorders of the nervous system after medical procedures not classified in other categories
• Ortostatic hypotension
• Migraine
• Nonspecific low blood pressure
• Mother's medical care in connection with other states associated mainly with pregnancy.
• Benign intracranial hypertension

Dosing mode

Inside, during an attack of headaches 1-2 tablets 2 times a day, then 1 tablet 2-3 times a day for several days (up to 1 month).

Side effects

From the nervous system: excitation, anxiety, tremor, anxiety, headache, dizziness, cramps, paresthesia in the limbs, strengthening of reflexes, tachipne, insomnia; With a sudden cancellation - braking CNS, increased fatigue, drowsiness.

From the cardiovascular system: heartbeat, tachycardia, cardialia, hypertension (increase blood pressure).

From the digestive system: nausea, vomiting, diarrhea.

Allergic reactions: swelling, skin itch.

Others: With prolonged use - weakness in the legs, Malgia, Lerish syndrome (cyanosis, no pulse on the lower limbs, pain, distillation violation of distal type).

Contraindications

It is impossible to use the drug at elevated excitability, at high age, with glaucoma, expressed atherosclerosis and elevated arterial pressure, severe heart disease.

Pregnancy and lactation

Cofetamine is contraindicated during pregnancy and breastfeeding.

Interaction

Enhances the pharmacological effect of other LS, containing the alkaloids of the ardines and caffeine. Caffeine is an adenosine antagonist (large doses of adenosine may be required).

With the joint use of caffeine and barbiturates, a prison, anticonvulsant drugs (Derivatives of Hydanoin, especially phenytoin), it is possible to strengthen the metabolism and an increase in caffeine clearance; Cimetidine, oral contraceptive drugs, disulfyram, ciprofloxacin, norfloxacin - decrease in caffeine metabolism in the liver (slowing down its removal and increase in blood concentration).

Means causing the stimulation of the central nervous system are excessive stimulation of the CNS.

Mexylene reduces caffeine removal up to 50%; Nicotine increases the rate of caffeine.

Inhibitors of Mao, Faurazolidon, Procarbazin and SELEGILIN - large doses of caffeine can cause the development of dangerous heart arrhythmias or pronounced blood pressure.

Caffeine reduces the absorption of Ca2 + preparations in the gastrointestinal tract. Reduces the effect of narcotic analgesics and sleeping pills; Enhances nonarcotic analgesics (increasing suction). Increases the removal of Li + preparations with urine.

Accelerates suction and enhances the effect of cardiac glycosides, increases their toxicity.

Sharing caffeine with beta adrenoblockers and can lead to a mutual suppression of therapeutic effects; With adrenergic bronighting ls - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine can reduce theophylline clearance and, possibly, dr. Xanthines, increasing the possibility of additive pharmacodynamic and toxic effects.

The vesseloring effect of the drug amplifies the alpha-adrenostimulants, beta-adrenobloclars, serotonin agonists (including Sumatapan) and nicotine.

Macrolids increase the toxicity of ergotamine (decreased by the liver clearance of caffeine).

Storage conditions

In a dry, cool, protected place. Keep out of the reach of children.

vasoparalytic migraine form;

Arterial hypotension;

As a means lowering intracranial pressure at vascular, traumatic and infectious lesions of the central nervous system.

Form of release of the drug Coffee

shell-covered tablets; Tube 10, pack cardboard 1;
shell-covered tablets; Packaging Contour cell 10;
shell-covered tablets; Packaging Contour cell 10, pack cardboard 1;
shell-covered tablets; Packaging Contour cell 10, pack cardboard 2;
Composition
Tablets covered with shell 1 tab.
Caffeine 100 mg
Ergotamine Tartrate 1 mg
in the packs of contour cells or test tubes of 10 pcs.; In a pack of cardboard 1 or 2 packs or 1 test tubes.

Characteristic
Cofetamine is a combined antimigrenous drug.

Pharmacodynamics of the preparation of Cofetamine

The effect of the coffee maker is associated with the vasoconductive effect of ergotamine and the improvement under the influence of caffeine of the cerebral functions.

Ergotamine causes a vesseloring effect.

Caffeine accelerates the absorption of ergotamine and enhances the effect of alkaloids of the ardines in the treatment of migraines. Caffeine also causes the stimulation of the central nervous system, mainly the cortex of the brain, respiratory and vasomotory centers. Enhances mental and physical performance, reduces drowsiness, feeling fatigue. Caffeine has a pronounced cardiotonic effect: increases the strength and frequency of heart abbreviations, increases blood pressure under hypotension.

Using a Cofetamine preparation during pregnancy

Cofetamine is contraindicated during pregnancy and during lactation.

Contraindications for use of the drug Coffee

Hypersensitivity, pregnancy, lactation period. Caution. Sleep disorders, alarming disorders (agoraphobia, panic disorders), organic diseases of the SCC (including acute myocardial infarction, angina, pronounced atherosclerosis, paroxysmal tachycardia, frequent ventricular extrasystolia, arterial hypertension, irritation of peripheral vessels), hepatic and / or Renal failure, glaucoma, elderly age.

Side effects of the drug Coffee

From the nervous system side: excitation, anxiety, tremor, anxiety, headache, dizziness, cramps, paresthesias in limbs, reinforcement of reflexes, tachipne, insomnia; In case of sudden cancellation, the increase in the braking of the CNS, increased fatigue, drowsiness. From the side of the SCC: heartbeat, tachycardia, cardialgia, increased blood pressure. From the digestive system: nausea, vomiting, diarrhea. Allergic reactions: swelling, skin itch. Others: With long-term use - addiction, drug addiction, weakness in the legs, Malgy, Lerish syndrome (sharp cyanosis, no pulse on the lower extremities, pain, distillation violation of distal type). Recovery. Symptoms: Strengthening the severity of side effects, incl. Nausea, vomiting, numbness in fingers and legs, inhibition, drowsiness, epileptic seizures, stupor, coma. Treatment: washing the stomach, the reception of activated carbon, if necessary, the conduct of symptomatic therapy.

Method of use and dose of the drug Coffee

Inside 1-2 table. During an attack of a headache 2 times a day, then 1 table. 2-3 times a day for several days (up to 1 month). Maximum single dose - 2 tab., Daily - 4 tab.

Overdose by the preparation of Cofetamine

Symptoms: anxiety, nervousness, irritability, insomnia, face redness, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor excitation, tremor, hypertension, confusion, hyperreflexia, numbness in fingers and legs, epileptic seizures.

Treatment: Cancel Cofetamine; washing the stomach, the appointment of activated carbon, if necessary, conducting symptomatic therapy; Beta-adrenoblays (propranolol) warn cardiotoxic effect and normalize blood pressure.

The interaction of the drug Cofetamin with other drugs

Enhances the effect of other means containing the alkaloids of the ardines and caffeine.
With the joint use of coffee and barbiturates, prison, anticonvulsants - Derivatives of Hidantoin (Phenitoin), it is possible to strengthen the metabolism and an increase in caffeine clearance.

With the joint use of coffee and cimetidine, oral contraceptives, disulfyram, ciprofloxacin, norfloxacin is possible to reduce caffeine metabolism in the liver, slowing down its excretion and an increase in blood concentration.

With the joint use of coffee and means of stimulation of the CNS, excessive stimulation of the CNS is possible.

Caffeine is adenosine antagonist.

Mexylene reduces caffeine removal up to 50%; Nicotine increases the rate of caffeine.

Large doses of caffeine can cause the development of hazardous arrhythmias of the heart or a pronounced pressure increase against the background of admission of inhibitors of Mao (Furazolidon, Zamazbazin, SELEGILIN).

Caffeine reduces the absorption of calcium preparations (calcium gluconate, calcium carbonate, calcium combination with vitamin D) in the gastrointestinal tract.

Cofetamine reduces the effect of narcotic analgesics and sleeping pills, increases the removal of lithium drugs (lithium carbonate) with urine, accelerates suction, enhances the action, increases their toxicity of heart glycosides (digoxin, celands).

Co-use of coffee with beta-adrenoblockers (atenolol, metoprolol, nebivolol) can lead to a mutual suppression of therapeutic effects; with adrenergic bronighting agents (Clenbuterol, salbutamol, phenoterol) - to additional stimulation of the central nervous system and additive toxic effects.

Caffeine can reduce theophylline and aminoophylline clearance, increasing the possibility of additive pharmacodynamic and toxic effects.

The vesseloring effect of the coofamine is enhanced by alpha-adrenostimulants, beta-adrenoblays, serotonin agonists (including Sumadapan) and nicotine.

Macrolides (erythromycin, spiramsycin, josamicin, midecamicin, clarithromycin, azithromycin, roxitromycin) increase ergotamine toxicity.