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What are leukocytes in gynecology. Leukocytosis: when and why occurs, forms, classification and function of leukocytes |
The most famous laboratory and diagnostic procedure is a blood test. This is a kind of health test, since blood counts determine the condition of a person, possible pathologies in the body and the degree of destruction of the diseased organ. Complete blood count indicates the level of hemoglobin, the number of red blood cells, leukocytes, lymphocytes, platelets and shows a picture of the general condition of the body. A blood test can determine the presence of infection and, allergic reactions,. The doctor decrypts the blood test, given the age, illness, pregnancy and menstrual cycle in women. Before you take a blood test, it is recommended to follow certain rules. Do not overeat, do not physically overload the body, do not take heat treatments, do not drink a lot and do not eat spicy food. These factors can make an incorrect adjustment to a blood test, which makes it difficult to establish a correct diagnosis. Leukocytes in the bloodAn important indicator of the state of the body is the level of leukocytes. These are white cells with a nucleus that react to the slightest changes in the body.When problems arise, the body is forced to produce increased number leukocytes, which serve to protect and create a barrier against microbes, viruses, foreign cells and microorganisms. There are that depend on age. Norms of leukocytes (x 109):
Causes of elevated white blood cell countWhy are leukocytes elevated, and what does it mean? The main indicator of the presence of a malfunction or illness in the body is the number of leukocytes. The importance of this number lies precisely in the fact that an increase in leukocytes signals a disease.With such pathologies, an increase in the level of leukocytes in the blood is possible:
When does leukocyte count increase? With colds, acute respiratory infections, otitis, bronchitis, as well as diseases involving tissue destruction. There are five types of white blood cells:
Leukocyte formula indicates a possible course of pathological processes. More accurate diagnostics can be carried out by calculating the absolute level of indicators. The relative and absolute changes in the level of leukocytes have a difference in that absolute numbers more accurately approach the true state of the organism. In order for the general blood count to be closer to true, it is not recommended to take food before giving blood, it is better not to take a hot bath a day before taking the test and avoid bathing in a cool pond. You should not physically load the body, overeat, drink alcoholic beverages. During pregnancy, leukocytes increase in the blood, so the doctor may prescribe a control general analysis or other urine and blood tests. Which doctor to contact for treatment?If, after reading the article, you assume that you have symptoms characteristic of this disease, then you shouldLeukocytosis: when and why occurs, forms, classification and function of leukocytesThe species composition and function of leukocytes are diverse. The reaction to the events taking place in the body is instantaneous. In most cases, leukocytosis is considered as a defensive reaction, but there are other reasons for the increase in the number of white blood cells. The leukocyte population (Le) is fairly organized, even it seems that they almost have intelligence, because everyone knows that what is happening and where they are unmistakably sent to their lesions, recognize “their own” and “someone else's”, kill unwanted “guests”, which are often infectious agents. They respond to trouble in the body by increasing activity and increasing content in peripheral blood. Leukocytosis - the so-called this process. In their populations, there is a strict hierarchy: who is meant to be commanded, and whom - to execute flawlessly. It is flawless, because otherwise the complex structure of interactions will break and the organism will not cope. That is why, only a person gets to the hospital, the first thing they take is a “two”, that is, leukocytes, since leukocytosis is an important diagnostic feature of many diseases. Causes of LeukocytosisIn order not to be frightened and properly assess the situation when the analysis is delivered and there is a clear increase in white blood cells, you need to know causes of leukocytosis, which can be very diverse:
In connection with the foregoing, there are varieties of leukocytosis, which formed the basis of its classification. Classification and characterization of white blood cellsApproximately half a century ago, the lower limit of the norm of leukocytes ranged from 5, 5-6,0 G / l, now this level has dropped to 4.0 G / l, or even less. This is due to ubiquitous urbanization, increased radioactive background, the use of a large number of drugs, sometimes unreasonable. However, leukocytosis has not disappeared anywhere and, under certain circumstances, makes itself felt as a symptom of some disease, since it is not an independent nosological unit. The following types of leukocytosis are distinguished:
The classification of leukocytes and leukocytosis is based on the types of white blood cells, their functions and behavior. White blood cells, depending on the presence or absence of specific granules in the cytoplasm, are divided into two rows: granulocyte and agranulocyte. What kind of cells are these - leukocytes? Why do they behave like this and why do they care? What do the concepts " neutrophilic and eosinophilic leukocytosis, Which are often mentioned by doctors? Why is leukocytosis dangerous or is it not dangerous at all? And you can understand this, if you know the basic properties of leukocytes. The main properties of leukocytes, their tasks and functionsThe size of leukocytes, depending on the type, ranges from 7.5 to 20 microns, they contain many enzymes (peptidases, lipases, diastases, proteases), which are in isolation in isolation (in lysosomes) and are called lysosomal enzymes. Leukocytes perform their functions outside the vessels, and they use the vascular bed only as a road. They are characterized by the amoebic movement, through which they penetrate the capillary endothelium ( diapedesis) and sent to the lesion ( positive chemotaxis). Reverse movement of leukocytes from the source of irritation is called negative chemotaxis. If we talk about the rate of leukocytes, here the range of variation is quite wide (4.0-9.0 G / l)besides, blood taken from a finger contains information only about the sixth part of white cells, because tissues are their main habitat. And in order to understand where the norm is, and where the pathology is, of course, you need to know what the leukocyte population is, what tasks it performs, what they are for, and whether it is worth worrying if suddenly there is a high content of white cells. The life span of leukocytes depends on the species and ranges from several days to 20 years or more. Long live is intended for those leukocytes that have become “memory cells”, because even after a long period of time they are obliged to recognize the “alien” that they met many years ago. “Remembering” him, they must immediately “inform the interested” species. Those, in turn, must "give the command" to destroy the stranger. The main tasks of white blood cells can be represented as follows:
A detailed blood test provides for counting not only the total number of leukocytes, but also the percentage of all types of white blood cells in a smear. By the way, the percentage should be converted to absolute values ( leukocyte profile), then the information content of the analysis will increase significantly. Granulocyte rowThe ancestors of leukocytes (myeloblasts) belonging to the granulocyte series originate in the bone marrow, where they pass through several stages and do not enter the bloodstream until the end of maturation. In peripheral blood in certain pathological conditions (or purely by chance - 1 cell) metamyelocytes can be found. These are young (young) cells, they are also the precursors of granulocytes. However, if young for some reason appear in the blood, and at the same time they can not only be seen, but counted in a smear, it means that you can judge left shift (for leukemia, infectious and inflammatory diseases). An increase in the smear of old forms indicates right shift formula. formation of blood cells from stem cells in the bone marrow Granulocyte cells are endowed with pronounced enzymatic and metabolic functions, therefore, their characteristic neutrophilic, eosinophilic and basophilic granularity is closely related to the activity of the cell and for each species it strictly specific, i.e. it cannot be transformed from one type into another. Granulocyte RepresentativesUncontrolled malignant proliferation (reproduction) is called (should not be confused with leukocytosis). Leukocytes in this disease cease to perform their function, since they could not differentiate because of a failure in blood formation. Thus, leukemia is dangerous not so much by increasing the number of white cells as by their lack of skills to perform their functions. Treatment of leukemia is a difficult task for hematologists, which, unfortunately, is not always solved successfully. It depends on the form of leukemia. Many people believe that leukocytes exist to show the presence or absence of inflammation, and meanwhile, the scope of white blood cell activity is very wide. If leukocytes (in particular, T-cells) would not be affected by HIV infection, we probably could have overcome AIDS. The success of organ transplantation depends entirely on the behavior of these cells. Sensing "someone else's", they can immediately issue a command for destruction, and the organ in the new owner will not take root. Leukocytes have a lot to do ... Video: leukocytes in the program "Live Healthy!"Step 3:In the bloodstream are present uniform elementsresponsible for protecting the body. White corpuscles of irregular round shape originate in the bone marrow, and then go to the general bloodstream. Despite the fact that they perform a very important function, when leukocytes are elevated in analyzes, it is worth looking for pathological changes or strong inflammatory process. Cells immune system divided into several types. They are different in structure, purpose and origin. The main task of leukocyte bodies is to protect the human body from penetrating pathogenic agents, allergens, harmful substances. In addition, due to their ability to penetrate through the walls of blood vessels into organs and tissues, and then return back to the bloodstream, they actively eliminate the waste products of "enemy targets." Leukocytes: functional featuresWhite blood cells move throughout the body through blood flow. If they “hear the alarm”, which speaks of the invasion of a dangerous enemy, they immediately react and rush to the source of infection or implantation. Penetrating into the tissue, leukocytes (WBC) are moved with the help of prolegs. Due to the large size of the protective cells can capture the inside of the enemy agent and digest it. The process of destruction is called phagocytosis. After performing its task, the white bodies die, therefore, with multiple infection of the body, a large number of white blood cells are required. Another important function of immune elements is the production of antibodies to pathogenic microorganisms. If at least once leukocyte bodies are found with pathogenic microbes and destroy them, immunity or resistance to this disease develops. Thus, with repeated penetration of the same microorganism to which antibodies have been developed, the person will remain healthy. WBCs are actively involved in metabolic processes, supplying cells with hormones, enzymes and useful elements that are in demand in the body. Types of leukocytes: what are they responsible for?
Refer to the phagocytes, they can be segmented (Mature) or stab (immature). There are also younger cells, metamyelocytes. By the number of forms of different degrees of maturation determine the patient's health. Most of all in the bloodstream should be segmented neutrophils (45-75% of all leukocytes), much smaller stab and very few young ones. By their ratio, the intensity of blood formation in the bone marrow is detected. If a significant amount of metamyelocytes is found in the bloodstream, then significant blood loss is suspected. The main task of granulocytes is phagocytosis. Neutrophils do an excellent job with the destruction of foreign agents, the production of antimicrobial substances and the elimination of the effects of intoxication in the body. After phagocytosis, the white bodies die and pus appears in the damaged area.
The main task of the basophilic WBC is to be a member allergic reaction. These cells have the ability to penetrate through the blood vessels in the tissue. Histamine and heparin are present in the cytoplasm. As soon as an allergen enters the body, basophils instantly react to the attack, reporting the development of an allergic reaction. Of the total number of leukocyte bodies, they account for only 0.5-1%.
Non-segmented leukocyte elements begin to absorb foreign pathogens only when they are transformed into macrophages. Then they become large calves. Monocytes ply throughout the body, capturing "pests" of the same size as themselves. In the general bloodstream, their content is 3-11%.
The main defenders of the body that produce antibodies to pathogens. They account for 20-35% of all WBC. Taurus controls whether foreign agents have appeared or if a mutation of its own cells has occurred. Macrophages collect all information on suspicious elements and transfer it to lymphocytes. When elevated leukocytes is a signal of danger?It may seem that since immune cells play a protective role, there are not many of them. But in fact, the concentration of WBC in a person’s blood should be limited. To understand what level is considered the norm, you need to consider the data from the table. It is important to note that in adults, indicators are stable, and in children they vary with age (measured in units times 10 9 / liter). Elevated white blood cells are detected during the development of an inflammatory or pathological process. In women, during hormonal surges (before the menstrual cycle, pregnancy, the postpartum period), the level increases to 10.2 units. But this phenomenon is temporary and is not considered an alarming factor. But there are situations when an excessive level of leukocytes (leukocytosis) arises due to various pathologies of the hematopoietic system. Leukocyte cells increased: symptoms
If the results of tests determine leukocytosis, it can not be ignored. At the initial stage of development of pathological changes it is very easy to cope with the disease. But the chronic form of the inflammatory process is much more difficult to cure. In addition, violations in the body can cause irreversible complications. Causes of blood test abnormalities
With a significant increase in leukocytosis (when a blood test is 2-3 times higher than normal), more serious irregularities in the body should be sought. They are benign (reactive) or malignant. The first type of leukocytosis develops as a result of the following diseases:
Benign abnormalities disappear after the main problem is treated. But leukemias are very poorly treated and, unfortunately, it is not always possible to get rid of the malignant pathologies of the hematopoietic system. The severity of violations is determined by the level of leukocytes in the blood. The more of them, the more difficult the disease progresses. In order to determine the approximate cause of deviations of indicators, an extended diagnosis of leukocyte formula is carried out. The root cause of leukocytosis depends on a group of immune defenders that exceed the norm. There are such types of violations:
To identify the exact cause of elevated WBC and individual groups of immune cells, it is very important to conduct additional diagnostics. The therapist, after taking the history, will be able to refer the patient to a specific specialist. High leukocyte cell count in pregnant women
The immune system in women during this period may be weakened. Therefore, the bone marrow produces an additional amount of white blood cells to cope with the possible ingress of foreign agents. Despite the increase in performance, shifts in the formula for the percentage of each group of bodies are usually not observed. A high concentration of protective bodies in pregnant women is provoked by hormonal jumps, stressful situations, and toxicosis. In recent months, the WBC is more detected in the uterus, because the body has already prepared for the birth of a child. Pathological causes of leukocytosis include the following factors:
Any abnormalities in the body of a pregnant woman are a dangerous condition, as they can lead to miscarriage in the early stages or underdevelopment of the fetus. Leukocytosis can cause internal bleeding, which is why it is so important to undergo routine examinations and is under the supervision of a specialist before delivery. It should be remembered that you need to ask for help as early as possible. If the disease is prolonged, it will be difficult to treat it with drugs safe for pregnant women, which will aggravate the state of health. Detection of leukocyte bodies in the urine
If there are an increased number of immune cells (leukocyturia) in urine tests, the following diseases can be suspected:
Various diseases cause a significant increase in performance. At the same time, the collected biomaterial will be turbid, and sediment will fall to the bottom of the laboratory capacity. For a more accurate determination of the cause of leukocyturia, a three-stacked test is performed. If white blood cells are found in the first container, this indicates a prostate or urethritis. If they dominate the third glass, then it is cystitis. And with a uniform distribution of indicators in all capacities, kidney damage can be judged. It is important to note that with an increase in WBC of 60 units, the state is called pyuria. It manifests itself with a strong bacterial lesion of the urethra or bladder. In patients, urine becomes a green-yellow shade, acquires an unpleasant odor. Hematuria - blood impurities in the urine can talk about urolithiasis, tumors, injuries, prostate enlargement. In women during pregnancy, a high concentration of leukocyte cells may adversely affect the development of the fetus. Most often this happens with inflammation of the kidneys, bladder, development of thrush or candidiasis. In most cases, leukocyturia therapy is carried out with antibiotics. If leukocytosis is diagnosed in a vaginal smear Women in consultation with a gynecologist always pass the analysis of the mucous substance for flora. If the figures exceed 15, then we can talk about leukocytosis in a vaginal smear. In most cases, the diagnosis allows to determine the presence of various pathogens (gonococci, fungal infection, candida, Trichomonas, etc.). Leukocytosis in a smear indicates these diseases:
If the deviations are prolonged, then a biomaterial diagnosis for the presence of bacteria (streptococcus, staphylococcus, Escherichia coli, ureaplasma) is also prescribed. Pathogenic microorganisms that cause inflammation of the genital organs (chlamydia, genital herpes virus, trichomonas, syphilis) are detected by DNA research. In rare cases, leukocyte cells increase to a rate of 100 units. Sometimes no other infections are detected in the smear, and leukocytosis is high. This happens when vaginal dysbiosis. During pregnancy in women, due to a decrease in immunity, the microflora that was constantly in the body often becomes pathogenic and provokes an inflammatory process in the genital tract. One of the most manifested is thrush, which usually worries in recent months. Leukocytosis in pregnant women is dangerous because they cannot be used with antibiotics, but an infectious pathogen can get into the fallopian tube and interrupt the development of the fetus. Excess indicators in men: urogenital diagnosis
If men have a leukocytosis in a smear, then most often it is preceded by such diseases:
Most often, an increase in the number of immune cells in a urogenital smear indicates sexually transmitted infection. Even before some symptoms can be diagnosed, it can be understood that the inflammation is acute. As a rule, to the signs of violations genitourinary system carry cramps when urinating, cheesy discharge, pain in bladder, sores on the head of the penis. If the test results show that there are not so many leukocytes, but other indicators exceed the norm, then, most likely, the inflammatory process has already passed into the chronic phase. Features of leukocytosis in children: how is it manifested?In infants and newborns it is very difficult to detect any changes in the circulatory and hematopoietic system before the test. Deviations are asymptomatic or there are signs of congenital abnormalities that cause an increase in white bodies. With a significant jump in performance in children who are a few days old, congenital leukemia is usually fixed. He is diagnosed with heart disease, defects in bodily constitution, Down syndrome. But this is very rare. If high rates are found in a child older than a year, then the phenomenon may be caused by physiological factors:
When the pathological reason for the development of leukocytosis is usually diagnosed with infectious diseases (ARVI, bronchitis, pneumonia, rubella, chickenpox, etc.). When WBC is detected in the feces in children (above 8-10), intestinal microflora may be impaired. Doctors send the child for analysis for prolonged indigestion, rashes on the body, refusal to breastfeedingweight loss. The reason for concern of parents should be a change in the nature of the chair, its fetid odor, frequent emptying. If the mother sees mucus in feces or notices an unusual texture, then an examination of the presence of an inflammatory-infectious process in the body should be carried out. In infants, leukocytosis in the feces is found in the following diseases:
But if the indicators deviate slightly and do not bother the child, he does not refuse to eat and remains active, then the parents should not be cause for concern. Most likely, the increase is due to physiological factors, not pathologies. As lowto be overpricedyy indicators?
Most often, treatment is carried out by the following groups of drugs:
If a patient has too high leukocytosis, the hematologist may suggest a procedure for leukapheresis. It is intended to force the removal of excess leukocytes from the bloodstream using a separator. But in case of serious diseases, its effect will be short-lived. Help and means to lower the level of leukocyte cells traditional medicine. But they can be used only after an accurate diagnosis has been established and in cases where there is no danger of developing complications and side effects. The following plants help to remove the inflammatory process: Horsetail .The composition contains silicon, so the plant component reduces the level of white blood cells. Squeeze juice from fresh horsetail and drink 2 sips three times a day. Reception is carried out before meals. From the dry mixture is prepared decoction. For a glass of water take 1 tbsp. horsetail and insist 8 hours. It is taken in the same way as juice. Propolis .It is a natural antibiotic, therefore suitable for treatment. infectious diseases. You can prepare the tincture of 3 parts of propolis and 7 parts of alcohol. Pre-slice the bee product put in the freezer, and then rub on a grater, for rapid dissolution. And alcohol should be 70%. Insist 20 days in a dark place. After that, take 1 tbsp., Diluting with water. During exacerbations, they drink at least 5 days three times before meals. Linden .For the preparation of medicines take a tablespoon of flowers and pour a glass of boiling water. The liquid is boiled over low heat for another 10 minutes. Broth take a glass of 2-3 per day. Especially useful to drink tea with SARS and flu. PreventionIn order not to miss the development of the disease, it is necessary to regularly undergo planned medical examinations. If on early stage notice deviations of leukocytes, it is much easier to cure it than a chronic process. Preventive measures that protect against leukocytosis are:
As soon as the test results reveal excess of the white bodies, the exact cause of the violations should be ascertained and the doctor’s recommendations for their treatment should be followed. |
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