Articles for the competition "bio / moving / text": Psychiatry stretching out all the rockets of the ball in the direction of all the main halluses of medicine. Pokey traumatologists robbed X-ray signs, and therapists instilled blood analyzes, psychiatrists simply rocked their patients and spied on them. Now genetics with modern technologies come to the aid of psychiatrists.

The general sponsor of the competition is the company: the best supplier of the possession, reagents and vitreous materials for biological dosages and technologies.

The sponsor of the Prize of Gladdy Sympathy and the partner of the nomination "Biomedicine for the New Year and Tomorrow" was the company "Invitro".

"Book" sponsor of the competition - "Alpina non-fiction"

Psychiatrists were always defective in their activity. For some ten years that patient could have done electroencephalography or pneumoventriculography for a neurological breakdown. And as soon as it became clear, the patient passed into the hands of neurosurgeons or neurologists. Psychiatry prodovzhuvali pratsyuvati with those children, who did not have any kind of pure viyaviti.

With the increase and the accelerated arsenal of medical advances, psychiatry began to declare its right to receive them on a regular basis, but not so for the time being. For example, we know that the progress of Alzheimer's ailments will lead to a decrease in the amount of hipocampus - in the brain, knitted from memory. Also, it seems that the use of anti-dementia drugs can reduce the loss of hippocampal speech. Winning nutrition: how often do patients with dementia use an MRI scan of the brain with a papillary obsyagu hipocampi? Like to lie on the surface: practical nicoli.

Psychic illnesses are taken on an empty mission. Often it is possible to see a provocative social factor in the development of the development, or without the need to forget about biological officials. Our skin has geni, on the basis of which the foldable life of our cells, including neurons, will be based. In order for the intelligence to be reduced to reality, it can be genetically tested in psychiatry, it is necessary to assess its effectiveness and consistency before being put into wide practice. We need to correct the output for the power supply. Їx an approximate list can be seen as follows:

1. Do you inject genetic factors into the development of psychotic problems? Psychic problems - there is a large group of illnesses, in the case of demoralization of affective pathology (depression, bipolar affective disorder [BAR], triple illness), ailments with psychotic symptoms (schizophrenia, mental illness) Obviously, for skin ailments, genetic additions will be recognized. For some reason, intelligence is necessary, for any pathologies it will be maximal.
2. How can the civil servants settle down, so that they pass from generation to generation? Behind the help of genetic dysfunctions, it is possible to understand the appearance of genetic disorders in mental disorders. Did the stench come from Batkiv, Babus and Didus? For spostering the winery at the very patient (mutations de novo)? Only great fundamental advances to help us know the difference in nutrition.
3. How can you see a specific gene or a group of genes, which can be used to affect the development of pathology? Crackers to produce good results. The stench can know a specific gene, which is responsible for the development of ailments, and you can find a sprinkle of geniv, which is injected onto the ailment itself or some symptoms.
4. How can we know what are the genetic factors that initiate antipsychotics, antidepressants and other drugs for mental disorders? Pharmacogenetic testing - the chain of genetic factors associated with the peculiarities of the metabolism of the drug, the development of side effects in case of yogo acceptance. Pharmacogenetic testing can be useful for predicting side effects and patient reactions to the drug.
5. Is it reasonable to carry out genetic testing in case of mental breakdowns from the point of view of ethics? Otrimaning the given tributes can be tsikavim, and the very way of rejecting them superficially tsikavi, it is important for us to assess the correctness and adherence to the quality of information. We can’t spend the last bit of knowledge; It is important for us that the stench of the bully is economically efficient and did not cheer on the school's patients and their homeland.

The list can be supplemented in the presence of the surroundings, the alley vector is clear. The propagation of the doslіdzhennya is informative, and the donation is guilty we will be rulled from the economic point of view and morally acceptable. As soon as we give ourselves to one of the clerks at once, then it is genetic testing in case of mental breakdowns of matime sense.

walking abnormalities

Fundamental genetic adolescence in case of mental breakdowns can bring a significant amount of acne. Molecular methods can be used in the classification of mental disorders, in the clarification of their relationships, as it is, as the stench was identified with brown when the specified levels of dispute in roslin, food and microorganisms were identified. The parity of genetic dosages is steadily decreasing, the accessibility for an ordinary koristuvach grows and protects health as a whole (Fig. 1). This means that great genetic predictions will be more and more included in the common practice of pre-ages and politicians.

Diagnostics of mental disorders is prompted by the patient's scars and the results and the look, and not by the given instrumental dosages. Infected in the USA, the RDoC project is being implemented ( Research Domain Criteria), Conjugation on the appearance of links between specific genetic variants and features of the function of the normal brain and brain, ruined by a mental disorder. The accumulation of money for this project can lead to a change in the classification of psychic problems, to go to diagnostics and treatment.

Infection of the method of genetic testing in case of mental breakdowns, mainly, intermingling of chromosomal damage (yak, for example, Down's syndrome) or monogenic ailments (yak, for example, ganglionosis) (Fig. 2).

The destruction in the structure of DNA has been good for more than ten years, and it has evolved into a kind of medical practice. The problem of mental disorders of the field is that, for the greater part of them, it is impossible to know a specific gene, which is responsible for the development of ailments. Psychic troubles - the whole of polygenic inconveniences, the development of such dressings with broken functions all the way to the deciles of genes, as well as the changes in the hem of the relationship. In addition, a part of the disease is significant, for example, in schizophrenia, it is tied to the diagnosis of mutations de novo It’s not so easy.

It should be done before new methods appear in the spheres of genetic dosages, which will allow to take a fresh look at the component of pathogenesis in a new way:

• Ekzom's sequencing (whole exome sequencing) - a method of conjugation of the same part of DNA, yak code of the library. Oscillations for codification are only 1% of all nuclear DNA after-effects, so it is faster and cheaper, less sequential.
• by no means a sequencing (whole genome sequencing) Vivchaє is not only the sequence, but the code of nuclear DNA, ale and promoter regions, enhancing, but also mitochondrial DNA. The whole method gives a great amount of information, ale and corsnity in the specific type of skin to be assessed in a reasonable way.
• RNA sequencing (RNA-seq) Assess the structure of the matrix RNA, which is not a straightforward calculation of the DNA code. At the end of the day, the method is as follows: it’s not a genetic assessment itself, but it’s like getting involved in the robot’s movement.

In addition to these methods, it is possible to increase the amount of money that can function in all the nerve cells and in their interaction. Analysis of transcriptome is promising for the development of genetics of mental disorders. The transcript is the cost of all RNA, which is violated in the cells. The breeders of їх vivchennya mi diznaєmosya, such as bіlki, in whichever droplets and in whichever number, vyroblyayuyu clitinoy. Alternative splicing is seen in the brain more often, not in other organs, so the very consistency of DNA does not need to give us enough information about those that are synthesized on the basis of this.

At its own devil's sack, genetic damage can be greater, less skin is okay with them. Already seen this kind of interaction with schizophrenia and Alzheimer's ailments with a small ear. The great prelude to 2014 had nearly 4,000 genes, linked to disorders in the autism spectrum, syndrome of deficiency of respect and hyperactivity (SDH), schizophrenia and X-related disorders of intellectual development. 435 of the most significant genes were seen in a number of genes, and a total of 789 nonsynonymous single nucleotide substitutions (SNP) were substituted. Having shown a further analysis, genetic options could have been introduced into a number of important processes in the middle of the nerve cells (Fig. 3). Lots of "perekrittya" boules appeared in the last few years. For example, at the development of a near-cordon line of specialty and bipolar affective distribution of findings a number of the same genes, for example DPYD and PKP4. In addition, during the development of a polygenic rhizic, the development of some psychotic problems revealed a genetic closeness (Fig. 4).

Malunok 3. Nayrіznomanіtnіshі psychіchnі razladі zagalі zagalnі molecular basis on івні білків. There are 13 modules of proteins, which are included in the key processes of all the middle neurons. Modules with significant features in the frequency of the primary candidate genes are known as a star. Lines with numbers - interrelationships between modules and modules. Mindset: ASD- spread the autism spectrum, ADHD- syndrome of deficiency of respect and hyperactivity, SZ- schizophrenia, XLID- X-connection failure of the intellectual development.
Schob hit the little ones in general size, press on the new one.

Malunok 4. When developing a polygenic rhizic of a bipolar affective disorder, schizophrenia and depression, it was revealed that a part of the genes, related to the development of one ailment, was found in the pathogenesis of other mental disorders. Mindset: Mean standardized PRS- average standardized assessment of polygenic rhizik, BOR- prikordonne disharmony of specialties, BIP- bipolar affective disorder, SCZ- schizophrenia, MDD- depression.

It seems like the idea of ​​specific genes is to make the sound of endophenotypes in schizophrenia and changes in the great regions of the genome. Endophenotyp - the chain of behavioral abnormal physiological signs, which is stable and stable with specific changes in genetic tributes. At the same time, the signs do not reach the level of the symptom. Shvidshe for everything, the term "specialty" comes up to them. Before endophenotypes, for example, they must admit the brokenness of the disclosure of emoticons and problems with them, like the patients of the keru with their hands. Problems with the development of emotion have appeared to be linked to changes on chromosome 1p36, if there is a gene that is a serotonin type 6 receptor code. Cei receptor is a target for typical and atypical antipsychotics - drugs that show high efficacy in patients with schizophrenia.

In general, the situation with genetic pre-diagnoses in casual psychiatric pathology is not intricate. Zanadto bogato gen_v pour on the development of psychotic problems. With a lot of stinks, I get a lot of weak results, so I can use new mathematical methods for my analysis. Zanadto foldable dosage is required for the identification of weak links: the stench remains inaccessible in wide practice.

Reconstruction of summity

Genetic adolescents with mental breakdowns are not surrounded by only a joke of the reasons for the ailment and their ideas. Infected all the greater popularity of the drug Pharmacogenetic testing - the discovery of the peculiarities of enzymes, such as problems in the metabolism of lykarsk workers. Our organisms and divine workers have a family of enzymes called "cytochrome p450". The whole family includes more than 50 enzymes, 6 of them in the metabolism of nearly 90% of all medicinal preparations. The ci axis strikes the metabolic front: CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5. For the metabolism of psychotropic drugs, CYP2C19 and CYP2D6 are of great importance.

So, for example, 85% of antidepressants and 40% of neuroleptics metabolize the CYP2D6 enzyme. You should know your image in the frequency of development of specific side effects in case of vicorian psychotropic drugs. Patients with high activity of CYP2D6, who accept therapy with antipsychotics, are more potent to the development of piznya (tardy) dyskinesia, lower those who have the enzyme less active. Dyskinesis is a specific syndrome, we can trivialize the reaction with neuroleptics and prevent them from getting rid of them. During the development of the patient, rapists appear, repeat the hands and lips. In case of important forms, one gets the first group of muses: the patient gets the rapists, tulubs, kintsivoks. These problems can arise from imperceptibility, tremors and lykarsky parkinsonism. Korektsiya piznyoi dyskinesia for the additional help of lykarskiy zasobіv - tse foldne zavdannya. For a reason, you will be pricked to apply a zusilla for a zapobigannyu. Given that it is possible to indicate that the lack of activity of CYP2D6 can lead to a malignant neuroleptic syndrome. After receiving antipsychotic patients, the patient will start to charge at the first temperature. The new one has a change in the increase in the tone of the muscles, the change in the frequency and the pulse and the arterial grip, as well as the deterioration of the developmental step. It’s one of the quiet birthplaces in psychiatry, as she herself can bring the patient to death.

Evident Pharmacogenetic Data in Psychiatric Relationship with the Robot CYP2C19 and CYP2D6 Enzymes. Genetic testing may be due to the large number of robotic enzymes in fallowness, since the allele of the gene is presented in humans and in many copies. Before the functional variants of CYP2D6, the variants CYP2D6 * 1, CYP2D6 * 2 are considered in any cases with other alleles. As the gene of madodatkovі copies, the enzyme is proactively active in transferring Volodar into the group of “ultra-fast” metabolizers. "Promizhni" and "major" metabolisers for CYP2D6 can cause changes in risk of development of side effects, and therefore, in lower doses of drugs in case of psychotic disorders. For the activity of the CYP2C19 enzyme, people can also be divided into "ultra-fast", "extensive", "intermediate" and "general" metabolizers. The broadening of the young alleles changes in the fallowness of the races, until there is a patient.

The enzymes CYP2C19 and CYP2D6 play a key role in the metabolism of tricyclic antidepressants, the middle necessary for amitriptyline. Yogo is widely victorious in psychiatry, neurologists and therapists at the very age of illnesses. In the course of metabolism, amitriptyline is aware of the transformation, so that it can be brought into the mental state until it changes (Fig. 5). Amіtriptylin yak tertiary amin can be infused into the serotonin system. If you are using CYP2C19, it will turn into nortriptyline, which is actively involved in the robot of norepinephrine transmission. More active enzyme, less "serotonin" component in the injection of amitriptyline and less noradrenaline. Thus, as CYP2D6 is received in the metabolism of tricyclic antidepressants, its activity is injected into the health of the preparation injected into the patient's station. In "ultra-fast" metabolizers according to CYP2D6, it is recommended to repair a drug that is not of a class. If a patient with such metabolic peculiarities will accept the therapy of tritsiklikami, then it is necessary to regularly assess the concentration of the drug in plasma. For the "common" metabolizers, the recommendations are as follows. If it is necessary to take tricyclic antidepressant, then the cob dose is responsible for 50% of the recommended starting dose. Similar recommendations are given for CYP2C19. At the same time, there is no need to think that the genetic testing of the discussed enzymes is not exotic. In 2005, the FDA grabbed the AmpliChip CYP450 system, given data on the genetics of enzymes. Some recent generations of CYP2C19 and CYP2D6 are available in our country.

Malunok 5. In the human body, amitriptyline is converted into nortriptyline, an active metabolite of amitriptyline, after the additional enzyme CYP2C19. CYP2D6 takes the fate of the transformed both molecules into an inactive form.

With just one butt of the already existing Pharmacogenetic Testing, which is straightforward to the problem of minor, albeit not safe side effects, є the screening of the HLA-B * 1502 marker in particular Asian hikers. During therapy with carbamazepine in patients with a gene missing, they develop a risk of development of Stevens-Johnson syndrome, a potentially fatal defeat of children, with any type of epidermis being seen. The FDA recommends testing the HLA-B * 1502 marker prior to cob carbamazepine therapy.

Is Bagato Knowledge - Bagato of Sorrows?

Kozhen times, if you go about the introduction and testing of the diagnostic method into medical practice, it is necessary to assess its correctness. How much is it possible to carry out genetic tests to patients with psychotic ways, who will be corny for them? What do I think is important information for diagnosing and diagnosing a group of illnesses?

At the in-line stage of development of the genetics of psychic problems, the brownness is summed up from them. Zanadto richly unimportant and disgusting stagnant on practical results give a long time to navigate with great vibration. The main reason for this is the cardinal vision of mental disorders from monogenic ailments. In the classic type of monogenic disease (for example, Gentington's ailments), it is possible to analyze the structure of one gene, the minds of the patient, and the patient has a problem. With such a value, it will be useful to predict the development of Gentington's ailment in the potential nose of the gene. It is possible to guess thirteen from the "Doctor House" serial, which, by one analysis of the analysis, can be promoted to her Huntington's ailment.

Psychic problems may have a genetic basis. Tse polygennі zvoryuvannya, the development of such dressings with the wrinkle of robots bagatioh genіv one hour. The appearance of cutaneous genes did not bring important diagnostic information for the doctor, at least for the on-line stage of development of the process of knowledge. There is also little sense of contagion in predicting the development of a mental breakdown on the basis of genetic diseases in skin people and relatives of already living patients. In the development of mental disorders, a great role is played by the middle factor - the socially-economical camp, the serious shock in the life, the life of the people. There is no information, as if a lyudin was taken away, but he wasn’t hungry for a mental disorder, he’s brought up a trivial problem for his health. ... On the other side, the manifestation of some kind of genetic risk in people є is negatively placed on the side of those who are sick (“I’m the genius of schizophrenia, and it means that at any moment I can become a schizophrenic”). There will be a quick improvement in the life of the people. If the risik himself may be insignificant, all words and ideas of people can be taken through the prism of this potential madness. Lyudin with a prokhovanim rizik of a psychotic disposition can be made with the knowledge of ailments without the ailment itself. Corrosiveness here, zychano, є sumnіvnoy.

There is also a problem of being well-trained with advanced gene 5-HTTLPR (serotonic transporter), which is often associated with antisocial behavior (aggression, malice against power). A short version of the gene with a small number of repetitions in its structure to prevent people from provoking threatening situations and provoking the activity of the hypothalamic-hypophyseal-supra-nerve system. As a result, the short version of the 5-HTTLPR gene will show more antisocial behavior than the one who has the most variant of the gene. As long as everything is clear: everybody is protesting, protesting against the gene. Let us formulate the group and we will lead more caution after it, so that we can help the poor and eat the young people until they are in trouble. Yak, it seemed, it was smoothly on the porch, and they started talking about yari. "Yarom" in a wide range of vypapayut factors of middle age, sprout, social and economical mind, in any growth of children. If we are talking about disadvantaged areas, then in them they overwhelm them with an anti-social behavior, create economical and social factors (bezrobittya, rivn 'illumination). It means that to get rid of all the necessary interventions at every stage of the world, come in and paint the social classroom as a whole. The injection of variants of the 5-HTTLPR gene will become usable in case of successful social and economic minds. To go around, "genetic" bullies need to be shukati not in slums and ghettos, but among representatives of the middle class and unhealthy townspeople, which should be cheap.

Development of genetic dosages in the spheres of psychic problems in trivatime. The directors will carry out pre-treatment, we have є pharmacogenetics data, which allow us to reasonably accept the decision, so that we can identify side effects and achieve a good therapy result. Rizrakhunok development of ailments and diagnostics of mental disorders until they become collapsible and unattainable in practice. We will be encouraged to change in an hour.

literature

1. On the ruins of the memory: the day and the maybutn of Alzheimer's ailments;
2. Jack C.R. Jr., Petersen R.C., Xu Y., O'Brien P.C., Smith G.E., Ivnik R.J. et al. (2000). Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology. 55 , 484–89;
3. Mamoru Hashimoto, Hiroaki Kazui, Keiji Matsumoto, Yoko Nakano, Minoru Yasuda, Etsuro Mori. (2005). Does Donepezil Treatment Slow the Progression of Hippocampal Atrophy in Patients With Alzheimer's Disease? Two gene co-expression modules differentiate psychotics and controls. Mol psychiatry. 18 , 1308-1314;
4. Bin Zhang, Chris Gaiteri, Liviu-Gabriel Bodea, Zhi Wang, Joshua McElwee, et. al .. (2013). Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer's Disease. Cell. 153 , 707-720;
5. A S Cristino, S M Williams, Z Hawi, J-Y An, M A Bellgrove, et. al .. (2014 rock). Neurodevelopmental and neuropsychiatric disorders represent an interconnected molecular system. Mol psychiatry. 19 , 294-301;
6. S H Witt, F Streit, M Jungkunz, J Frank, S Awasthi, et. al .. (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Transl psychiatry. 7 , E1155;
7. Tiffany A. Greenwood, Neal R. Swerdlow, Raquel E. Gur, Kristin S. Cadenhead, Monica E. Calkins, et. al .. (2013). Genome-Wide Linkage Analyzes of 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia. AJP. 170 , 521-532;
8. Lynch T. and Price A. (2007). The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am. Fam. Physician. 76 , 391–396;
9. Needham D., Teed N., Pippins J. (2011). CYP2D6 and CYP2C19 genetic testing for psychiatric drug response. Personalized Medicine Portal;
10. Maju M Koola, Evangelia M Tsapakis, Padraig Wright, Shubulade Smith, Robert W Kerwin (RIP), et. al .. (2014 rock). ... J Psychopharmacol. 28 , 665-670;
11. Agnieszka Butwicka, Szymańska Krystyna, Włodzimierz Retka, Tomasz Wolańczyk. (2014 rock). Neuroleptic malignant syndrome in an adolescent with CYP2D6 deficiency. Eur J Pediatr. 173 , 1639-1642;
12. J K Hicks, J J Swen, C F Thorn, K Sangkuhl, E D Kharasch, et. al .. (2013). Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic Antidepressants. Clin Pharmacol Ther. 93 , 402-408;
13. P Brent Ferrell, Howard L McLeod. (2008). Carbamazepine, HLA-B * 1502and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. Pharmacogenomics. 9 , 1543-1546;
14. Yak vryatuvati thirteen? (Prospects for the treatment of Huntington's ailments);
15. Jorim J. Tielbeek, Richard Karlsson Linnér, Koko Beers, Danielle Posthuma, Arne Popma, Tinca J. C. Polderman. (2016). Meta-analysis of the serotonin transporter promoter variant (5-HTTLPR) in relation to adverse environment and antisocial behavior. Am. J. Med. Genet.. 171 , 748-760;
16. Catherine Tuvblad, Martin Grann, Paul Lichtenstein. (2006). Heritability for adolescent antisocial behavior differs with socioeconomic status: gene-environment interaction. J Child Psychol & Psychiat. 47 , 734-743.

Practical apparitions, as we can get through, spiraling on the figures and facts, glimpse in the offensive - information about the manifestation of psychotic problems in the family, I will accept the child as well as I can help the daddy to face the difficult
If you see, in my homeland I will accept a child of a bully, a problem of mental illness, not just at once the informational process - you should take a consultation from a geneticist about the steps to develop a developmental process. Remember, that there is a desire for psychiatric outcomes and transmission in recessions, not less strong inflow, not less genetic officials, for the development of a sickness to rob the middle, in the growth of a child - the development of education, socially perfecting of a child, Psychic and behavioral learning among children is found in the little booths and booths of the child, which is tied up with marriage and respect to children in cich installations. The very fact of living in the family, and not in the minds of the mind, to rob the virtual inflow on the mental health of the child. Yak butt can be cited as a result of a single piece of advice that was developed in Izrail. At the same time, they sponsored two groups of children, people who were sick with schizophrenia of fathers. Children from the same group grew up in their own family, and children from the same group grew up in a kibutz, dey bully, they were not close to the ideal, on the thought of kibbutz dreamers, mind your life. However, after 25 years, it appeared that schizophrenia and affective incidence of schizophrenia and affective incidence of schizophrenia appeared in such an ideal childish ward, but not among children who grew up in the family, do not want to see any kind of well-being.
The first symptoms of mental ailments, for example schizophrenia, can manifest themselves back to the ear of the ailment itself. Whenever you appear and develop, you can go up to 10 rockets. Characteristics of these symptoms are not the subject of this statistic, but there are some similar recommendations for guilt in psychiatry. On the other hand, it means that there is a change in the behavior of a child, mental weakness, sleep impairment, impaired sleepiness, decreased performance in school, guilty of guarding fathers and serving as a drive for incapacitation to an appropriate drug user. At the same hour, when I look at the zagalny character of the pererakhovanih signs, it is not a matter of warto zanadto to be wary of being shown to the child. A real ghost for the rest of the world can only be blamed in the same way as a new bully ill on the schizophrenia of close relatives. Well, you know, well, the child's symptoms of ailment are clearly manifested in the child, how to get sick, remember, well, on the thought of the psychiatrists, early involvement in the development of psychosis and more effective adaptation.
It can also be concluded that schizophrenia seems to be the most important from all overwhelmed mental disorders. The clever manifestation of the ailment is even worse than the development of the ailment - the development can be interrupted by one attack, which does not fit into the life of the sick. In the most important types of schizophrenia, there are no vicissitudes of specialness, outside of the social life, if ailments are not only impossible to solve, but they cease to live behind their own kind people who are watching them.
You can also learn how to study molecular genetic analyzes for detecting mental illnesses. As if in any medical pledge you will propose the development of analysis for schizophrenia, or for some mental problems, but on the whole, in a short amount of time, there will be a polymorphism of genes, you can use it to develop mental health problems. With all the teachings in the Danish hour, it is impossible to say unambiguously how to introduce the geni into the development of the ailment. It is also recommended that we be carefully placed until an hour at a time is announced in the mass information, which informs about the appearance of the aggressiveness gene, the gene for kleptomania, or the schizophrenia gene of Chergov. Given the fact that a candidate gene has changed in a group of patients with a control group.
At the end, I want to go out of the scientific viclade and go into the area of ​​assessment of the problem from the point of view of a healthy living sense and quiet humane positions, on how a lyudin stands up, a virile take on a child. Tie your life with a child's ailment or a child, the decline of which is covered with important psychotic ailments, we are preparing before the news of the problem before the news of the problem. In such a situation, it’s more intelligent to help the child, and not to see it for himself, more than that, but the destruction of the child-father is only to cope with the problem. Remember, the inflow of the slump is great, but not indefinitely, and a lot of problems are not tied to the organic deterioration of the psyche. It seems like it’s not a good idea to be a genius and a “rotten spade”. It is said in one of the Earth's handbooks in psychogenetics, geni - there are no good or nasty pictures, but they were very vivid to the skin of us, otherwise, as the stench would be realizable in the world, to lay down in the world of some of these factors, can be trimati under control.

pid bag

1. In medicine, in the capacity of the possible causes of mental disorders, three factors are discerned: the manifestation of traumatic conditions, the trivial inflow of unwelcoming minds, the internal body of the body, including a decline in mental capacity.

2. Psychogenetics has great respect not only for the joke of the slow-moving mechanisms of the mental disorders, but also for the development of the middle factors in the development and possibilities of the middle therapeutic injections ("environmental engineering"). For an hour, the term “genome” will remain in order, as soon as the term “Envira” (from the English environment) is used, it is an understanding that includes a middle factor.

3. Schizophrenia is one of the most common mental illnesses, characterized by impaired processes of misery, spirits, emotional and volova spheres.

a. The level of schizophrenia among the population is becoming close to 1%. Among relatives of schizophrenic ailments, the frequency of illnesses is low in the population. Rizik become ill-fated to move from the higher stages of dispute. For the Ministry of Health, twins will be close to 50%. Tse talk about іnuvannya decay component of the ailment.

b. Until now, there is no single model of genetic transmission of schizophrenia. Most of the pre-eminents are involved, but the basis for the sedation of schizophrenia can be a multifactorial polygenic threshold model with possible epistasis effects.

4. depressive discord

a. Depression is a psychotic disorder, which is characterized by being driven, ruined, respect, sleep and appetite. Depression can be supravodzhuvatisya see anxiety and excitement, or, navpaki, lead to apathy and baiduzhosti to the feeling. From the depression of the guardians, close to 5% of the population.

b. Depression tends to concentrate in the surroundings. Relatives of depressive ailments may have a greater schism to the point of becoming ill, lower than the population as a whole.

c. The results of genetic predictions of depression are significant in the prevalence of diagnostics and methods.

d. In the battle of the family, there are often distressing stances in the order of the depressive distributions. Є Let the allowance be made, but at the base of the troublesome and depressive problems lie the backward reasons. Depression, such as schizophrenia, malnutrition є multifactorial recessionary illnesses of folding nature.

5. Non-return until the beginning of the day

a. Specificity before the beginning - SNT (learning disabilities) often ottozhnyayut from the understanding of the reception of the mental development. SNT united a number of cognitive problems, scho zavazhayut school navchannya, unaffected by the savings of intellect. The number of children who suffer from specific damages of reading, letters, rakhunka for deyakim estimates of the warehouse is 20-30%.

b. The middle of the SNO is the best vivchenoi є the specificity of reading (dyslexia) is specific, as well as "verbal slapota". Admitting that the cause of dyslexia is specific damage in the cells of the brain. The symptoms of dyslexia are of a family nature.

c. In genetic dyslexia, there is a folding multifactorial sign of a threshold effect. The phenotypic variability of dyslexia is superspecifically great and changes from time to time. In this hour, you can see the possibility of zones and chromosomal localization of dyslexia.

In robots vikoristovyvayutsya statistics

1. Alfimova M.V. "Infusion of genetic decline into behavior" (Ph.D., Provincial Scientist of the Laboratory of Clinical Genetics at the Scientific Center for Mental Health of the Russian Academy of Medical Sciences).

2. Vakharlovskiy V.G. "Genetic illnesses and diagnostics in foster children" (Ph.D., medical geneticist).

3. Golimbet V.Є. "Infusion of slump on the mental health of people" (Doctor of Medical Sciences).

4. Nikiforov I.A."Factors to take the development of debris from psychoactive words"

5. Rudenska G.Є. "Medical genetics: how can we help our fathers and children" (Doctor of Medical Sciences, Chief Scientist of the Russian Academy of Medical Sciences).

Pathological recession, as I will reject the child from the father, is a provincial factor in the mental illness. It is not the ailment itself that settles down, but the snakes of the decaying substrate of the DNA molecule, with the cunningness of the prettiest form of illness, as it develops with the interaction of modality and decay and navkolishny middle.

The decline is clear in the case of the most common mental illnesses.

Alcoholism.

Conducted follow-ups to show the increased frequency of development of alcoholism among close relatives. Uzagalnyuchi tributes, confiscated in the early hour in the rіznіh lands, mi otrimaєmo, so close to thirty hundred fathers and seventeen hundred mothers in the minds of alcohol addiction to alcohol, the hall was also guarded.

Nearly forty people were sick, they were suffering from alcoholism. Specific for alcoholic deposits є family background. Є numerical data about those who are not only relatives of the first stage, but the relatives of the other and third stage of the dispute, may have increased the frequency of accusations of alcoholism in relation to the frequency of the latter in the foreign population.

In case of a pre-existing problem, the pre-development of twins was carried out, the role of factors in the new middle age and the manifestation of genetic scholasticity in young children was introduced.

It has been reliably revealed that children who wander in the family did not have the illusion of alcohol, they may have a decline in mental capacity, statistically, they often fell ill for alcoholism in the context of children, as the school of schism was not small.

There was also carried out a detailed evaluation of the factors of the most recent middle and genetic factors. It was revealed that only a high level of alcoholism was not enough for the development of alcoholism, which confirmed the role of genetic grace, which is responsible for the high or low quality of the development of ailments.

Schizophrenia.

The genetics of schizophrenia has been born since 1916. Even earlier, psychiatry meant that statistically, it was statistically that it was more common to grow up in quiet families, because it was suffering from these ailments. In Danish hour, the leading role in the development of schizophrenia is to be attributed to genetic factors.

The price has been brought by the number of family and genealogical pre-siblings, pre-adolescent couples, adolescent children, which were carried out in the native lands. All bullet vyavleni have results.

In children, who are ill for schizophrenia, due to the accumulation of repeated illnesses. Children, for whom one father was suffering from schizophrenia, also suffered at the time of becoming ill in the middle of 15% of the population. The preoccupation with schizophrenia among children, the daughters of the fathers, who suffer from ailments, ranged from 35% to 47% (publicized data from young people).

Among the relatives of the other stage, the disease became ill in the lower stage, but among the relatives of the first stage, it was two or three times overwhelmed by the disease in the population.

With those mental illnesses, such as bipolar affective disorder (for colic classification of manic-depressive psychosis) and epilepsy is also indicated by the accumulation of repeated illnesses. Statistically, more often than not, it is more common to develop in the first stage of the dispute.

When the genetics of mental illness were evolved, it was revealed that at the fathers, who suffer from a mental illness, the child does not necessarily calm down the same ailment. Tse can be mentally ill.

For example, in a family of offense, one of the fathers suffered from schizophrenia, children statistically often suffer from depressive discord, alcoholism. Tse talk about the out-of-the-box mechanisms for the diagnosis and sedation of mental illnesses. Factors of the most recent middle ground can, as speed up, so and weaken the genetic mechanisms for the diagnosis of ailments.

So it is already laid nature- with all the stretching of life, there was a sickness and not once. GRZ, vitrianka, grip, angina - this is a small part of what the skin of us interferes with. Ale in the light there are such ailments, which are transmitted in the recessions, as the damn thing is more terrible. Їх Vinniknennya is important to transfer. Ditin, at which dad they suffered from a sickness, we were not necessarily guilty of getting sick, alerizik to develop a sickness at a new one will be high.

Today's day іsnu 3000 genetic diseases, Which are transmitted in recessions. Happily, in the middle of them, I will mainly store ailments, the rizik of the development of those in the child will become a deprivation of 3-5%. Genetic ailments, which are manifested practically in the skin generation, depending on the gene. With a whole nose of a sick gene, there can be one father, or an offense. It’s just that in the first vipad of Rizik, the development of genetic ailments in the child will be 2 times less.

best widening illnesses It is transmitted in recessions, diabetes, hypertension, psoriasis, color blindness, deafness, epilepsy and schizophrenia. Among them, the most insecure - mental illness, which negatively infuses on the adequate behavior of people. Psychic ailment entrains health by being able to mislead and normally get along with people.

create neurological decline Maybe people have a glimpse of something else, but they do not appear immediately after the people, but after 20-40 years. To such unfavorable changes in the nervous system, the following should be applied:

1. Khvoroba Parkinson... Most often, the enmity of the enemies of the people has gone for 50-60 years, then it has progressed unhealthily. Before the main ones, it is a sign of a breakdown in coordination of hands, tremor of hands, pidboriddya and nig, confidence in walking. In addition, with this ailment, it is possible to promote the visibility of the emoticons, the trust and respect, the destruction of the movement and the development of the depression. In the world of progressing ailments, memory and intellect are lost, it’s insistently sick, if the ailments along the coastline are up to the invalid river or lizka.

2. Alzheimer's ailment... Ailments begin to manifest themselves in the age up to 65 years, and at the early stages, the development is smoothly diagnosed through a nonspecific clinical picture. The first signs of Alzheimer's ailments are forgetfulness, confusion of evidence and lack of development, which were right, which were easy earlier. If dementia develops, there is no reason for gratitude and aggression, and in an hour the memory and waste of all vital functions of the body will break down.

3. Bichny amyotrophic sclerosis... The first manifestation of ailment, as you call it ALS, ailment may be seen in the same 40 years. ALS - nevilikovna progressive ailment of the central nervous system, when through degenerative lesions of the upper and lower nerve neurons of the brain, paralysis and atrophy of the muscles appear. As a result of all these processes in the course of a long period of time, there is a fatal result, an increase in the importance of pneumonia and / or dyshal muscles.

4. chorea of ​​Huntington... The name of the ailment is starting to show up from 20 to 50 years and is generally progressing. Zagvoryuvannya is characterized by mental deterioration and development of dementia. With the progress of ailments in a sick person there are hallucinations, no reason for the attack of aggression, hysterics and a new drop in specialness.

5. batten's ailment... Batten's ailment (NTsL) is manifested in a child or in an old age. At the same time, there is a purchase of fatty words in the cells of the nervous system. The head symptoms of ill health are headaches, headaches, epileptic attacks, rosum's appearance and seizures. An hour of manifestation of symptoms, the swiftness and severity of the progression of the ailment lie in whatever type of Batten's ailment. Anyone who is sick can cause sickness to death.

6. epilepsia... There are some of the most common neurological ailments on this day. One person from a hundred on Earth regularly trap epileptic attacks. The first attack of epilepsy, which may seem to have an inclinable character, appears in 5-18 years of age. In most cases of ailments on epilepsy, there are no psychic and intellectual problems, but they regularly suffer from attacks, but they are constantly opposing the second testimony and control over their actions. There is a need for ailments in the fact that the attack can be found in any mission and in any hour, perhaps the cause of death.

7. Myazova Becker's dystrophy... This disease manifests itself in 10-15 years of age and is characterized by damage to robotic muscles. A handful of ailments quickly get tired only with intense physical pressure, because of the weakness in the myases of nig growths, there are sudomi and spasms of the muscles. Building up to independent oversupply takes up to 30-40 years, at the last stages of ailments it takes a lot of dysfunctional and industrial functions, which can lead to death.