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Nitroxoline contraindications. What are Nitroxoline tablets taken from? Interaction with other drugs |
Nitroxoline is an antibacterial drug. Composition and form of releaseNitroxoline is available in the form of film-coated tablets. Each tablet contains 50 mg of the main active ingredient - nitroxoline. 10 tablets in blisters. Pharmacological action of NitroxolineAccording to the instructions, Nitroxoline is an antimicrobial drug derived from 8-hydroxyquinoline. The use of Nitroxoline is active against:
After applying Nitroxoline, it is rapidly absorbed from the gastrointestinal tract. The drug is excreted by the kidneys unchanged. Indications for useThe indications for Nitroxoline according to the instructions are the following conditions:
Method of administration and dosageAccording to the instructions, Nitroxoline is prescribed for adults at a dosage of 600-800 mg per day, divided into 3-4 doses. The interval between doses of the drug should not be less than 6-8 hours. The duration of treatment is two weeks. The maximum dosage per day is 1-1.2 g. The dosage of Nitroxoline for children is 10-30 mg / kg of body weight, divided into 3-4 doses. With persistently recurrent and chronic infections, the duration of treatment can be up to several months. According to the instructions, nitroxoline is taken one hour before meals with a full glass of water. It is necessary to strictly follow the treatment regimen for indications for Nitroxoline, do not skip taking the medication. If, nevertheless, the pill was missed, it is necessary to take it as soon as possible, and if it is already time to take the next pill, then the dose should not be doubled. If, during therapy with Nitroxoline, improvement does not occur for several days, you should consult a doctor about discontinuing the drug. Side effects of NitroxolineAccording to reviews, Nitroxoline can cause the following side reactions:
According to reviews, long-term use of Nitroxoline can cause optic neuritis. ContraindicationsAccording to the instructions, Nitroxoline is contraindicated:
special instructionsIt should be borne in mind that while taking Nitroxoline, urine turns yellow-orange. Storage conditions and periodsNitroxoline belongs to List B drugs with a recommended shelf life of 4 years. Nitroxoline International non-proprietary nameNitroxoline Dosage formCoated tablets 0.05 g CompoundOne tablet contains active substance- nitroxoline 50 mg, Excipients: core: milk sugar (lactose), potato starch, aerosil, talc, calcium stearate, shell: granulated sugar, basic magnesium carbonate, polyvinylpyrrolidone, aerosil, talc, pigment titanium dioxide (E171), tropeolin 0 (E103), acid red 2C (carmoisine, azorubin) (E122), beeswax. DescriptionFilm-coated tablets of light orange or orange color, round in shape with a biconvex surface. Three layers are visible on the cross section: inner - from yellow to grayish-yellow in color, a slightly greenish tint is allowed; the middle one is white and the outer one is light orange to orange. Pharmacotherapeutic groupAntibacterial drugs for systemic use. Other antibacterial drugs. Other antibacterial drugs. Nitroxoline. ATX code J01XX07 Pharmacological propertiesPharmacokinetics After oral administration, nitroxoline is well and quickly absorbed from the gastrointestinal tract. The maximum concentration (Cmax) in plasma is reached 1.5-2 hours after ingestion. The half-life (T1 / 2) is approximately 2 hours. It is excreted mainly by the kidneys unchanged, while high concentrations are formed in the urine (100 μg / ml and above). Pharmacodynamics Nitroxoline has a bacteriostatic effect by selectively inhibiting the synthesis of bacterial deoxyribonucleic acid (DNA). It is capable of damaging the cytoplasmic membrane and reducing the adhesion of uropathogenic strains to the epithelial cells of the urinary tract. Nitroxoline acts on both gram-positive and gram-negative microorganisms: Staphylococcus spp., Streptococcus spp., Enterococcus faecalis, Corynebacterium diphtheriae, Bacillus subtilis, Escherichia coli. ... It is active against Mycobacterium tuberculosis, Trichomonas vaginalis, some types of fungi (Candida spp., Dermatophytes, mold and some causative agents of deep mycoses). Indications for use
Method of administration and dosageThe drug is taken orally during or after meals. The tablets are swallowed whole, without chewing, washed down with the required amount of water. The duration of the course of treatment and the dose of the drug are set by the attending physician individually for each patient. Adults are usually prescribed 100-200 mg (2-4 tablets) of the drug 4 times a day. Daily dose for adults: 400 mg (2 tablets 4 times a day). In severe cases, the daily dose can be increased to 600-800 mg. The highest daily dose for adults is 800 mg. The course of treatment is 2-3 weeks. For chronic urinary tract infections, nitroxoline can be prescribed by repeated courses for 2 weeks with a two-week break. Side effectsOften: dyspeptic reactions (nausea, vomiting, loss of appetite) Seldom: allergic skin reactions decrease in serum uric acid and aminotransferases Rarely: tachycardia allergic thrombocytopenia intense yellow urine staining ataxia, paresthesia polyneuropathy headache liver dysfunction Contraindicationshypersensitivity to nitroxoline or any other components of the drug hypersensitivity to quinoline drugs severe liver failure severe renal failure (oligo-, anuria) neuritis, polyneuritis cataract deficiency of glucose-6-phosphate dehydrogenase pregnancy and lactation children and adolescents up to 18 years old Drug interactionsWith the combined use of nitroxoline with drugs of the tetracycline group, a summation of the effects of each drug is observed, with nystatin and levorin - potentiation of the action. You can not combine nitroxoline with nitrofurans in order to avoid the summation of the negative neurotropic effect. special instructionsIt should be used with caution in renal failure (under the control of the functional state of the kidneys) due to the possible accumulation of the drug. During treatment, urine may turn saffron yellow. Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms There is no data on the effect on the ability to drive a vehicle or potentially dangerous machinery. OverdoseThe site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required! Nitroxoline is an antimicrobial drug with a wide spectrum of action, which allows it to effectively destroy not only pathogenic bacteria, but also other microbes, for example, fungi of the genus Candida, Trichomonas, etc. Therefore, Nitroxoline is effective in the treatment of infections of the genitourinary organs, such as cystitis, urethritis, pyelonephritis, epididymitis, prostatitis, infected prostate adenoma or carcinoma.Nitroxoline - INN (international, non-proprietary name)The international non-proprietary name (INN) is the name of the active ingredient of a medicinal product. The same active ingredient can be contained in several medicinal products sold under different trade names. In reviews and other scientific or medical literature, it is often the INN of drugs that are used, so as not to list the commercial names of numerous generics and brand name drugs.The INN of Nitroxoline coincides with its commercial name - Nitroxoline. However, to avoid confusion, the INN is usually written with a small letter (lowercase), and the commercial name with a capital (uppercase). Nitroxoline - photoThese photographs show the packaging of Nitroxoline preparations produced by various pharmaceutical companies. Nitroxoline - composition, release form and dosageCurrently, Nitroxoline is available in a single dosage form - oral tablets... The tablets are coated in various shades of orange or yellow-orange. The shape of the tablets is biconvex, and three layers are clearly visible in the cut. Tablets are available and sold in packs of 10, 25, 30, 40, 50 or 100.As an active substance, each Nitroxoline tablet contains 50 mg nitroxoline... That is, the dosage of the drug is 50 mg of the active substance per tablet. The following compounds are contained in Nitroxoline tablets as auxiliary substances:
Is nitroxoline an antibiotic?No, Nitroxoline is not an antibiotic, although this drug has antimicrobial activity. Indeed, in practice, the range of drugs capable of detrimental effects on various microorganisms is very wide and is not limited to antibiotics. So, antimicrobial agents include antibiotics, antiseptics (for example, hydrogen peroxide, Chlorhexidine, Miramistin, alcohol, Uropimide, Urotractin, etc.), imidazole derivatives (Metronidazole, Ornidazole, etc.), sulfonamides (Biseptol, Chineceptol), (Nitroxoline, 5-NOK), etc. And Nitroxoline belongs to the derivatives of quinolones, that is, it is also included in the group of antimicrobial drugs, but is not an antibiotic.Pharmacological groupAll antimicrobial agents are divided into the following large groups:
Therefore, Nitroxoline belongs to the pharmacological group of antimicrobial agents, since it has a detrimental effect on various microorganisms. In this group, the drug is included in the subgroup of other synthetic antibacterial agents, derivatives of 8-hydroxyquinoline. Scope of application and therapeutic effect (from which Nitroxoline tablets)Nitroxoline is an antimicrobial drug that can have a detrimental effect on various pathogenic microorganisms that provoke infectious and inflammatory diseases of the genitourinary organs. The drug blocks the synthesis of nucleic acids (DNA) of microbial cells by forming complexes with enzymes that provide this process. Due to the blockage of DNA replication, microbes lose their ability to reproduce. A non-multiplying microbial cell lives its short term and dies.Due to certain differences in the structure of enzymes that ensure DNA replication in microbial and human cells, Nitroxoline has a selective action, destroying only pathogenic microorganisms and without negatively affecting the organs and tissues of the body. Nitroxoline has a detrimental effect on the following types of pathogenic microorganisms:
Nitroxoline, when taken orally, is very quickly absorbed into the bloodstream, after which it is excreted unchanged by the kidneys in the urine. Moreover, the accumulation of high concentrations of the drug occurs precisely in the urine, due to which Nitroxoline is a very effective remedy for the treatment of infectious and inflammatory diseases of the urinary and genital tract. Nitroxoline - indications for useIndications for the use of Nitroxoline are the following infections of the genitourinary organs:
In addition, the drug can be used to prevent infectious complications after surgical or diagnostic procedures on the kidneys and urinary tract (for example, bladder catheterization, cystoscopy, resectoscopy, etc.). Nitroxoline - instructions for useAgainst the background of taking Nitroxoline, the tongue, urine and feces may become saffron-red, which is a temporary transient reaction. After stopping the use of the drug, the color of urine, feces and tongue is normalized and completely restored.Dosages and duration of treatment for various diseasesNitroxoline must be taken orally four times a day. Receptions are distributed evenly throughout the day, so that the interval between successive tablets is 6 hours. A single dose of Nitroxoline is 100 mg, that is, two tablets. Thus, you need to take two tablets four times a day, for a total of eight pieces. If necessary, it is allowed to increase the daily dosage to 20 tablets (1000 mg of the active substance), which are also evenly divided into four doses per day.The duration of the course of treatment with Nitroxoline for acute diseases of the genitourinary organs is from 10 to 21 days, and depends on the speed of the onset of clinical and laboratory recovery. This means that the drug will have to be taken until all urine tests or vaginal swabs are normal. If therapy is necessary for any chronic, recurrent infectious and inflammatory disease of the genitourinary organs, then the total duration of the course of treatment can last for several months (up to six months). However, usually in such a situation, Nitroxoline is continuously taken in standard dosages (two tablets 4 times a day) for three weeks, after which they take a break for two weeks. Then, after a break, they again spend on drink a three-week course, take a break, etc. Thus, alternating three-week courses of taking Nitroxoline with two weekly breaks between them, it is necessary to drink the drug until the clinical symptoms disappear completely and urine tests normalize. For the prevention of infectious complications of diagnostic manipulations and surgical interventions on the organs of the urinary tract, Nitroxoline is taken two tablets (100 mg) 4 times a day, for 2 to 3 weeks. How to take Nitroxoline?The tablets should be swallowed whole without chewing or sucking on the shell. The tablets are washed down with at least 100 ml of water and taken with meals. In principle, Nitroxoline can be taken without regard to food, since its effectiveness does not depend on it. However, since the drug can cause nausea, vomiting and loss of appetite, it is recommended to take it with food in order to neutralize or reduce the severity of these side effects.Nitroxoline for cystitis - how to takeIf cystitis is acute and first-emerged, then the drug must be taken two tablets four times a day, for 10 - 14 days. In this case, you should observe equal six-hour intervals between each previous and subsequent receptions. This means that you need to take two tablets at 6-00 in the morning, then at 12-00 in the afternoon, at 18-00 in the evening and at 24-00 at night. Nitroxoline, even despite the disappearance of clinical symptoms, should be taken until the normalization of three urine tests taken for three consecutive days.If cystitis is chronic and its exacerbation is treated, then Nitroxoline should also be taken two tablets four times a day, at regular intervals. If two tablets do not lead to the disappearance of discomfort, then the dosage can be increased to 3 - 6 tablets at a time. The maximum daily dosage is 20 tablets (6 tablets per dose). In this case, the course of treatment should be extended to three weeks, after which a control urine test should be passed. If the analysis is normal, then the treatment can be considered complete. If the analysis does not correspond to the norm, then it is necessary to take a two-week break, and then repeat the three-week course of Nitroxoline therapy again. Instructions for use for childrenThe dosage of Nitroxoline in children is calculated individually, based on the ratio of 10 - 30 mg per 1 kg of body weight per day. Then the resulting dosage is evenly divided into 3 to 4 doses per day. For example, a child weighs 10 kg, which means that the daily dosage of Nitroxoline for him is 10 * 10 = 100 mg and 30 * 10 = 300 mg - from 100 to 300 mg, which corresponds to 2 to 6 tablets. We divide this amount into four doses per day - 2/4 = 0.5 and 6/4 = 1.5. That is, the child should take from half to one and a half tablets of Nitroxoline three times a day. However, it should be remembered that for a child under 5 years of age, the maximum daily dosage is 400 mg (8 tablets), and from 5 to 15 years, 600 - 800 mg (12 - 16 tablets).If the child does not have serious diseases of the digestive tract and nervous system, then you can not calculate the dosage individually, but use the following rules:
The duration of the course of using Nitroxoline in children is determined by the speed of recovery and ranges from 10 to 21 days. The tablets must be drunk not until the clinical symptoms disappear completely, but up to three normal urine tests taken within three consecutive days. That is, if the urine analysis does not correspond to the norm, and the clinical manifestations of the infection of the genitourinary organs have disappeared, then Nitroxoline must still continue to drink. Nitroxoline overdoseAn overdose of Nitroxoline is possible and manifests itself in the development of the following symptoms - tachycardia, nausea, vomiting, allergic rashes, headache and sensory impairment. Overdose treatment is carried out by temporary withdrawal of the drug and the use of symptomatic agents.Interaction with other medicationsWhen used simultaneously with any tetracycline antibiotics (Biomycin, Doxycycline, Tetracycline, etc.), Nystatin or Levorin, the therapeutic effects of both drugs are enhanced. Therefore, if it is necessary to simultaneously use tetracycline antibiotics, Nystatin, Levorin and Nitroxoline, their dosage should be halved.Nitroxoline in combination with nitrofuran derivatives (Furacilin, Furagin, Furadonin, Furazolidone, etc.) leads to increased side effects on the nervous system. Therefore, in order to avoid a negative neurotropic effect, these funds cannot be used together. Antacids containing magnesium (Maalox, Almagel), when taken simultaneously with Nitroxoline, reduce its absorption and effectiveness. Nitroxoline reduces the absorption of nalidixic acid, therefore, when they are used together, an increase in the dosage of the latter is necessary. Nitroxoline during pregnancyThe problem of using Nitroxoline during pregnancy cannot be assessed unambiguously, as it might seem at the first and "uninitiated" reading of the instructions. So, the instructions for use for the drug indicate that it is contraindicated in pregnancy and breastfeeding, but this does not mean that Nitroxoline can harm the fetus.So, the instructions indicate that Nitroxoline is contraindicated in pregnancy. This statement is based on the lack of accurate and scientifically reliable results of clinical studies of the drug in women "in position", which for obvious ethical reasons have not been conducted. In the absence of such studies, the manufacturer MUST indicate in the instructions for use that the drug is contraindicated in pregnancy. However, Nitroxoline has been used in clinical practice since about the 60s of the last century, and over the past 50 years, a wealth of experience has been accumulated in its use, including in pregnant women. For 50 years, gynecologists and obstetricians have been able to track that Nitroxoline does not have a negative effect on the fetus and does not increase the risk of miscarriage or premature birth, and therefore, if necessary, can be used during pregnancy. In the first trimester (up to the 12th week inclusive) and during the last 10 weeks of pregnancy (from the 30th to the 40th), Nitroxoline cannot be used, since during this period the fetus is especially sensitive to any drugs. And during the rest of the pregnancy, Nitroxoline can be taken if indicated. Nitroxoline for childrenNitroxoline is a drug with a high degree of safety for children, since it is excreted unchanged from the body by the kidneys (with urine) and does not undergo any metabolic transformation in the liver. This means that the drug does not in any way affect the child's liver, which is immature and weak, and therefore cannot absorb many drugs. It is because of the lack of effect on the liver that Nitroxoline can be used in infants from three months of age.For premature babies and infants under 3 months, Nitroxoline should not be used, since their kidneys are not yet sufficiently developed, as a result of which the drug can accumulate in the body, causing overdose and poisoning. Nitroxoline and alcoholIn principle, any treatment involves a complete rejection of alcoholic beverages, and this rule fully applies to Nitroxoline. However, in practice, in the life of each person there are different situations in which it is necessary to combine alcohol and drugs, including Nitroxoline.In general, Nitroxoline in combination with alcohol does not give any sharp, pronounced negative reaction, therefore, life-threatening conditions are unlikely to develop against the background of such a combination. However, it is impossible to predict in advance what will be the reaction of each individual person to the combination of alcohol and Nitroxoline, so their combined use is still not recommended. The potential danger of Nitroxoline in combination with alcohol is a strong negative effect and increased stress on the liver. Everyone knows about the negative effect of alcohol on the liver, and Nitroxoline in very rare cases can cause damage to this organ, which refers to its side effects. If this particular person develops this side effect of Nitroxoline while taking alcohol, then a lethal outcome cannot be ruled out. Contraindications for useNitroxoline is contraindicated for use if a person has the following diseases or conditions:
Side effects of NitroxolineNitroxoline is able to provoke the development of the following side effects from various organs and systems:1. Gastrointestinal tract:
5. Other: staining of urine in red-yellow color. Nitroxoline - analoguesCurrently, Nitroxoline has synonyms and analogues. Synonyms are drugs that, like Nitroxoline, contain nitroxoline (a derivative of 8-hydroxyquinolone) as an active active ingredient. Analogs of Nitroxoline are drugs that contain other active substances, but have similar therapeutic effects and spectrum of action.The synonyms for Nitroxoline include the following drugs:
Nitroxoline - reviewsMost of the reviews about Nitroxoline are positive, due to the properties of the drug. So, in positive reviews about Nitroxoline, men and women who used the drug note the following inherent advantages - efficiency, low cost, the ability to cure both cystitis and adnexitis in one course, as well as safety. In addition, almost all people in positive reviews note that Nitroxoline is effective for a wide range of both renal diseases and inflammation of the urinary tract and genitals. And since the inflammatory processes of the urinary and genital organs are often found together, Nitroxoline is a very convenient drug that allows them to be treated at the same time. It is thanks to these therapeutic effects that Nitroxoline receives positive reviews in most cases.In positive reviews, sometimes people indicate what, in their opinion, the disadvantages of the drug. Most often, the disadvantages of Nitroxoline are called the need for a long course of treatment, urine staining in an unpleasant red-yellow color, as well as side effects that can be very painful and uncomfortable. However, in the opinion of this category of people, against the background of the effectiveness, the possibility of simultaneously treating inflammation of both genital and urinary organs, as well as the low cost, these disadvantages do not reduce the overall quality of Nitroxoline. Negative reviews about Nitroxoline are very few. The reason for a negative review of a drug is most often its ineffectiveness in this particular situation, when a person has not received the desired effect. In addition, people who have left negative reviews note that the effect of Nitroxoline develops for too long, as a result of which unpleasant symptoms have to be endured for a long period of time. I also do not like the need for long-term use of Nitroxoline. It is the listed properties of Nitroxoline that some people do not like, and they leave a negative review of the drug. Nitroxoline for cystitis - reviewsPositive feedback on the use of Nitroxoline for cystitis is about 85 - 90%, which indicates the high efficacy of the drug. Women who have left positive reviews about Nitroxoline for cystitis, note that the drug allows you to very quickly relieve painful symptoms that go away literally after 1 - 2 receptions. In addition, many women suffering from chronic cystitis, having tried Nitroxoline, realized that they had found the very ideal drug for themselves, which quickly eliminates all symptoms and allows you to feel normal. People consider the need to take the drug 2 tablets 4 times a day for 2 - 3 weeks as a certain inconvenience, but this feature can be considered a lack of a good remedy. Women are ready to put up with this disadvantage, since there is nothing better, more effective and inexpensive at their disposal.Negative reviews about Nitroxoline for cystitis are about 10-15%. Usually negative reviews were left by women for whom Nitroxoline did not help cure cystitis or the symptoms did not go away instantly, after taking literally one dose of the drug. As a result, after taking 2 tablets of Nitroxoline, the women did not receive the immediate effect they had hoped for, the painful symptoms partially remained, which caused emotional disappointment in the drug, on the basis of which they left a negative review. It is noteworthy that among all the negative reviews about Nitroxoline, there is not a single one in which a woman would indicate that she had drunk the drug for a full two-week course, and it turned out to be ineffective. All negative reviews indicate that there is no effect after 1 - 2 days of using the drug, on the basis of which the woman made the decision to change the drug. It can be assumed that the negative reviews about Nitroxoline are due to the mismatch of expectations and the real effect of the drug. Nitroxoline - price in Russia and UkraineThe cost of Nitroxoline is low, which is explained by local production, as well as relatively cheap, domestic components of the drug. The difference in cost is usually insignificant and in most cases depends on the pricing policy of a particular pharmacy chain.In Russia, in various pharmacies, a package of Nitroxoline in 50 tablets costs from 43 to 67 rubles, and in Ukraine - from 6.95 to 10.55 hryvnia. In Russia, Nitroxoline in packs of 10 tablets is not sold, and in Ukraine, such a package costs from 1.88 to 2.45 hryvnia. Where to buy Nitroxoline?You can buy Nitroxoline at any regular pharmacy or through an online store. When buying, you need to pay attention to the shelf life of the drug, which is 4 years from the date of production. Immediately before use, the tablets must be carefully examined, and if they change color, crumble, break or have streaks on the surface, they should be considered damaged and, accordingly, unusable.The drug should be stored in a dry and dark place at an air temperature not exceeding 15 - 25 o С. Violation of storage conditions leads to the loss of the drug's properties, and therefore, its therapeutic efficacy decreases. Nitroxoline tablets: indications for use. With a bladder infection, patients resort to looking for effective drugs that can relieve excruciating pain and other unpleasant symptoms in the lower abdomen. Patients who have repeatedly encountered cystitis know for sure what the drug "Nitroxoline" is and what it helps from. The following is complete information about the drug and how it is used for cystitis. The drug "Nitroxoline" Nitroxoline tablets are used not only in the treatment of cystitis, urethritis, pyelonephritis, but also prostatitis in men. 1 tablet contains 50 mg of active synthetic substance nitroxoline and auxiliary components. The tablets have a convex shape and are covered with a bright orange shell. The drug belongs to uroantiseptics, to which many infectious agents are sensitive, causing an inflammatory process in the organs of the urinary system. The medicine suppresses the active activity of pathogens, which leads to their death. Uroantiseptic is well absorbed from the digestive tract and leaves the body almost unchanged by excretion through the kidneys. The medicine suppresses the active activity of pathogens, which leads to their death. How to take the drug?Tablets for cystitis are taken during or after meals with plenty of water. The daily dose for adults is 400 mg, divided into 4 doses. It is recommended to take the medication at regular intervals. If necessary, the dose can be doubled. In children aged 3 to 5 years, "Nitroxoline" is prescribed 200 mg per day, which are also divided into 4 doses. Children over 5 years of age are prescribed up to 400 mg per day. At the age of 12 years and older, the drug is used in the same dosage as shown for adults. On average, the course of treatment with Nitroxoline is 14-21 days. The treatment period can only be extended by a doctor. In the chronic course of the disease, tablets of this group are prescribed during an exacerbation. In some cases, the dosage and duration of admission is determined by the doctor, regardless of the indications of the instructions. Uroantiseptic has the following contraindications for use:
The use of "Nitroxoline" simultaneously with antibiotics of the tetracyclines group and "Nystatin" leads to an increase in the therapeutic effect of both drugs. Because of this, it is recommended that the dose of the latter drugs be halved. The use of "Nitroxoline" simultaneously with antibiotics of the tetracyclines group leads to an increase in the therapeutic effect of both drugs. During treatment with "Netroxolin" you should refuse to take medications containing magnesium, as they reduce the absorbing effect and effectiveness of the former. Uroantiseptic is able to reduce the absorption of drugs based on nalidixic acid. The most common side effects of antimicrobial medication are:
In isolated cases, there was a violation of liver function while taking "Nitroxoline". In case of headaches, nausea, vomiting and stool disorder, gastric lavage, the use of symptomatic medications and a temporary refusal to take uroantiseptic are necessary. Patients faced with cystitis know Nitroxoline tablets from what they are used and how quickly they help stop the inflammatory process in the bladder. But sometimes a drug can be replaced by an analogue by the attending physician. Drugs that have a similar effect include:
The drug "5-NOK" "5-Nok" refers to antibacterial agents of a number of 8-hydroxyquinolines, the active ingredient of which is the same nitroxoline. It has a similar treatment regimen, indications and contraindications. This also applies to the last two uroantiseptics. When nitroxoline-based drugs do not work properly or cause allergic reactions, the most effective medications may be prescribed. These include "Monural". It is a highly active uroantiseptic, the main active ingredient of which is fosfomycin trometamol. During the acute course of the disease, the drug is prescribed once. In case of recurrent forms, "Monural" is used repeatedly. The use of the drug is possible from the age of 5, provided there are no contraindications. It should not be used in patients with severe renal failure, as well as with individual intolerance to the components of the drug. The drug "Monural" As well as "Nitroxoline", "Monural" is not recommended for pregnant and lactating women. Which uroantiseptic to choose for the treatment of cystitis should be determined by the doctor. Self-administration of drugs increases the risk of complications and adverse reactions.
Article rating: estimates, average: is an antimicrobial drug with a wide spectrum of action, which allows it to effectively destroy not only pathogenic bacteria But other microbes, for example, kind of Candida, trichomonas etc. Therefore, Nitroxoline is effective in the treatment of infections of the genitourinary organs, such as cystitis, urethritis, pyelonephritis, epididymitis, prostatitis Infected prostate adenoma or carcinoma. The international non-proprietary name (INN) is the name of the active ingredient of a medicinal product. The same active ingredient can be contained in several medicinal products sold under different trade names. In reviews and other scientific or medical literature, it is often the INN of drugs that are used, so as not to list the commercial names of numerous generics and branded products. The INN of Nitroxoline coincides with its commercial name - Nitroxoline. However, to avoid confusion, the INN is usually written with a small letter (lowercase), and the commercial name with a capital (uppercase). These photographs show the packaging of Nitroxoline preparations produced by various pharmaceutical companies. Currently, Nitroxoline is available in a single dosage form - oral tablets... The tablets are coated in various shades of orange or yellow-orange. The shape of the tablets is biconvex, and three layers are clearly visible in the cut. Tablets are available and sold in packs of 10, 25, 30, 40, 50 or 100. As an active substance, each Nitroxoline tablet contains 50 mg nitroxoline... That is, the dosage of the drug is 50 mg of the active substance per tablet. The following compounds are contained in Nitroxoline tablets as auxiliary substances:
Some manufacturers add some more words to the name "Nitroxoline", wanting to emphasize that this particular drug was produced exactly at their facilities. An example of such drugs is Nitroxoline-UBF, Nitroxoline-AKOS, etc. Despite the letters "UBF" and "AKOS" in the names, this is exactly the same Nitroxoline produced by a certain pharmaceutical plant. No, Nitroxoline is not antibiotic Although this drug has antimicrobial activity. Indeed, in practice, the range of drugs capable of detrimental effects on various microorganisms is very wide and is not limited to antibiotics. So, antibiotics are referred to as antimicrobial agents, antiseptics (For example, hydrogen peroxide Chlorhexidine Miramistin Alcohol, Uropimide, Urotractin, etc.), imidazole derivatives ( Metronidazole Ornidazole, etc.), sulfonamides ( Biseptol Groseptol), quinolones (Nitroxoline, 5-NOK), etc. And Nitroxoline belongs to the derivatives of quinolones, that is, it is also included in the group of antimicrobial drugs, but is not an antibiotic. Therefore, Nitroxoline belongs to the pharmacological group of antimicrobial agents, since it has a detrimental effect on various microorganisms. In this group, the drug is included in the subgroup of other synthetic antibacterial agents, derivatives of 8-hydroxyquinoline. Nitroxoline is an antimicrobial drug that can have a detrimental effect on various pathogenic microorganisms that provoke infectious and inflammatory diseases of the genitourinary organs. The drug blocks the synthesis of nucleic acids (DNA) of microbial cells by forming complexes with enzymes that provide this process. Due to the blockage of DNA replication, microbes lose their ability to reproduce. A non-multiplying microbial cell lives its short term and dies. Due to certain differences in the structure of enzymes that ensure DNA replication in microbial and human cells, Nitroxoline has a selective action, destroying only pathogenic microorganisms and without negatively affecting the organs and tissues of the body. Nitroxoline has a detrimental effect on the following types of pathogenic microorganisms:
As can be seen from the above list, the spectrum of antimicrobial activity of Nitroxoline is wide and includes the vast majority of microbes that cause infectious and inflammatory diseases of the genitourinary organs. It is the poet who uses Nitroxoline to treat various infectious diseases of the genitourinary sphere. However, the drug can be used to treat any infection (for example, bronchitis, pneumonia, etc.) caused by any of the listed microbes. Nitroxoline, when taken orally, is very quickly absorbed into the bloodstream, after which it is excreted unchanged by the kidneys in the urine. Moreover, the accumulation of high concentrations of the drug occurs precisely in the urine, due to which Nitroxoline is a very effective remedy for the treatment of infectious and inflammatory diseases of the urinary and genital tract. Indications for the use of Nitroxoline are the following infections of the genitourinary organs:
Nitroxoline is effective in the treatment of the listed inflammatory processes, provided that they are provoked by microorganisms that are sensitive to it. In addition, the drug can be used to prevent infectious complications after surgical or diagnostic procedures on the kidneys and urinary tract (for example, bladder catheterization, cystoscopy, resectoscopy, etc.). Against the background of taking Nitroxoline, the tongue, urine and feces may become saffron-red, which is a temporary transient reaction. After stopping the use of the drug, the color of urine, feces and tongue is normalized and completely restored. Nitroxoline must be taken orally four times a day. Receptions are distributed evenly throughout the day, so that the interval between successive tablets is 6 hours. A single dose of Nitroxoline is 100 mg, that is, two tablets. Thus, you need to take two tablets four times a day, for a total of eight pieces. If necessary, it is allowed to increase the daily dosage to 20 tablets (1000 mg of the active substance), which are also evenly divided into four doses per day. The duration of the course of treatment with Nitroxoline for acute diseases of the genitourinary organs is from 10 to 21 days, and depends on the speed of the onset of clinical and laboratory recovery. This means that the drug will have to be taken until all urine tests or vaginal swabs are normal. If therapy is necessary for any chronic, recurrent infectious and inflammatory disease of the genitourinary organs, then the total duration of the course of treatment can last for several months (up to six months). However, usually in such a situation, Nitroxoline is continuously taken in standard dosages (two tablets 4 times a day) for three weeks, after which they take a break for two weeks. Then, after a break, they again spend on drink a three-week course, take a break, etc. Thus, alternating three-week courses of taking Nitroxoline with two weekly breaks between them, it is necessary to drink the drug until the clinical symptoms disappear completely and urine tests normalize. For the prevention of infectious complications of diagnostic manipulations and surgical interventions on the organs of the urinary tract, Nitroxoline is taken two tablets (100 mg) 4 times a day, for 2 to 3 weeks. The tablets should be swallowed whole without chewing or sucking on the shell. The tablets are washed down with at least 100 ml and taken with meals. In principle, Nitroxoline can be taken without regard to food, since its effectiveness does not depend on it. However, since the drug can cause nausea If cystitis is acute and first-emerged, then the drug must be taken two tablets four times a day, for 10 - 14 days. In this case, you should observe equal six-hour intervals between each previous and subsequent receptions. This means that you need to take two tablets at 6-00 in the morning, then at 12-00 in the afternoon, at 18-00 in the evening and at 24-00 at night. Nitroxoline, even despite the disappearance of clinical symptoms, should be taken until the normalization of three urine tests taken for three consecutive days. If cystitis is chronic and its exacerbation is treated, then Nitroxoline should also be taken two tablets four times a day, at regular intervals. If two tablets do not lead to the disappearance of discomfort, then the dosage can be increased to 3 - 6 tablets at a time. The maximum daily dosage is 20 tablets (6 tablets per dose). In this case, the course of treatment should be extended to three weeks, after which a control urine test should be passed. If the analysis is normal, then the treatment can be considered complete. If the analysis does not correspond to the norm, then it is necessary to take a two-week break, and then repeat the three-week course of Nitroxoline therapy again. More about cystitis If the child does not have serious diseases of the digestive tract and nervous system, then you can not calculate the dosage individually, but use the following rules:
Between the maximum and minimum daily dosage, one is chosen at which the unpleasant symptoms that prevent him from playing, sleeping, eating, etc. disappear in the child. That is, if a child complains of unpleasant and uncomfortable sensations for 0.5 tablets of Nitroxoline, then the dosage can be increased to a whole tablet. If after that the discomfort will pass, then it is necessary to stop at this dose. If the discomfort continues to bother the child, then the dosage is increased by another 0.5 tablets, etc. The duration of the course of using Nitroxoline in children is determined by the speed of recovery and ranges from 10 to 21 days. The tablets must be drunk not until the clinical symptoms disappear completely, but up to three normal urine tests taken within three consecutive days. That is, if the urine analysis does not correspond to the norm, and the clinical manifestations of the infection of the genitourinary organs have disappeared, then Nitroxoline must still continue to drink. An overdose of Nitroxoline is possible and manifests itself in the development of the following symptoms - tachycardia Nausea, vomiting, allergic headache and impaired sensitivity. Overdose treatment is carried out by temporary withdrawal of the drug and the use of symptomatic agents. When used simultaneously with any tetracycline antibiotics (Biomycin, Doxycycline Tetracycline Nystatin Levorin The therapeutic effects of both drugs are enhanced. Therefore, if it is necessary to simultaneously use tetracycline antibiotics, Nystatin, Levorin and Nitroxoline, their dosage should be halved. Nitroxoline in combination with nitrofuran derivatives (Furacilin, Furagin, Furadonin, Furazolidone, etc.) leads to increased side effects on the nervous system. Therefore, in order to avoid a negative neurotropic effect, these funds cannot be used together. Antacids containing magnesium (Maalox, Almagel), when taken simultaneously with Nitroxoline, reduce its absorption and effectiveness. Nitroxoline reduces the absorption of nalidixic acid, therefore, when they are used together, an increase in the dosage of the latter is necessary. The problem of using Nitroxoline for pregnancy cannot be assessed unambiguously, as it might seem at the first and "uninitiated" reading of the instructions. So, the instructions for use for the drug indicate that it is contraindicated in pregnancy and breastfeeding However, this does not mean that Nitroxoline can harm the fetus. So, the instructions indicate that Nitroxoline is contraindicated in pregnancy. This statement is based on the lack of accurate and scientifically reliable results of clinical studies of the drug on women "in position", which for obvious ethical reasons have not been conducted. In the absence of such studies, the manufacturer MUST indicate in the instructions for use that the drug is contraindicated in pregnancy. However, Nitroxoline has been used in clinical practice since about the 60s of the last century, and over the past 50 years, a wealth of experience has been accumulated in its use, including in pregnant women. For 50 years, gynecologists and obstetricians have been able to track that Nitroxoline does not have a negative effect on the fetus and does not increase the risk of miscarriage or premature birth, and therefore, if necessary, can be used during pregnancy. In the first trimester (up to the 12th week inclusive) and during the last 10 weeks of pregnancy (from the 30th to the 40th), Nitroxoline cannot be used, since during this period the fetus is especially sensitive to any drugs. And during the rest of the pregnancy, Nitroxoline can be taken if indicated. Thus, in principle, Nitroxoline, used in the second and early third trimester of pregnancy (from the 13th to the 30th week of gestation), does not cause any harm to the fetus, does not disrupt its growth and development, does not cause intrauterine malformations, and also does not increase the risk of miscarriages or premature birth, which is why many practicing gynecologists use this drug. Because of this, if the drug is prescribed by a gynecologist, then it can be taken without fear for the condition of your child. Nitroxoline is a drug with a high degree of safety for children, since it is excreted unchanged from the body by the kidneys (with urine) and does not undergo any metabolic transformation into This means that the drug does not in any way affect the child's liver, which is immature and weak, and therefore cannot absorb many drugs. It is because of the lack of effect on the liver that Nitroxoline can be used in babies already from three months of life. For premature babies and infants under 3 months, Nitroxoline should not be used, since their kidneys are not yet sufficiently developed, as a result of which the drug can accumulate in the body, causing overdose and poisoning. In principle, any treatment involves a complete rejection of alcoholic beverages, and this rule fully applies to Nitroxoline. However, in practice, in the life of each person there are different situations in which it is necessary to combine alcohol and drugs, including Nitroxoline. In general, Nitroxoline in combination with alcohol does not give any sharp, pronounced negative reaction, therefore, life-threatening conditions are unlikely to develop against the background of such a combination. However, it is impossible to predict in advance what will be the reaction of each individual person to the combination of alcohol and Nitroxoline, so their combined use is still not recommended. The potential danger of Nitroxoline in combination with alcohol is a strong negative effect and increased stress on the liver. Everyone knows about the negative effect of alcohol on the liver, and Nitroxoline in very rare cases can cause damage to this organ, which refers to its side effects. If this particular person develops this side effect of Nitroxoline while taking alcohol, then a lethal outcome cannot be ruled out. Nitroxoline is contraindicated for use if a person has the following diseases or conditions:
With moderate to mild chronic renal failure, Nitroxoline can be used with caution and under close medical supervision. In such a situation, a daily dosage of more than 800 mg (16 tablets) cannot be exceeded, since the drug can accumulate in the blood due to the low rate of excretion by the kidneys, and cause an overdose or poisoning. Nitroxoline is able to provoke the development of the following side effects from various organs and systems: 1. Gastrointestinal tract:
2. The immune system:
3. Central and peripheral nervous system:
The cardiovascular system: tachycardia (palpitations). Other: staining of urine in red-yellow color. Currently, Nitroxoline has synonyms and analogues. Synonyms are drugs that, like Nitroxoline, contain nitroxoline (a derivative of 8-hydroxyquinolone) as an active active ingredient. Analogs of Nitroxoline are drugs that contain other active substances, but have similar therapeutic effects and spectrum of action. The synonyms for Nitroxoline include the following drugs:
Nitroxoline analog drugs include the following:
In positive reviews, sometimes people indicate what, in their opinion, the disadvantages of the drug. Most often, the disadvantages of Nitroxoline are called the need for a long course of treatment, urine staining in an unpleasant red-yellow color, as well as side effects that can be very painful and uncomfortable. However, in the opinion of this category of people, against the background of the effectiveness, the possibility of simultaneously treating inflammation of both genital and urinary organs, as well as the low cost, these disadvantages do not reduce the overall quality of Nitroxoline. Negative reviews about Nitroxoline are very few. The reason for a negative review of a drug is most often its ineffectiveness in this particular situation, when a person has not received the desired effect. In addition, people who have left negative reviews note that the effect of Nitroxoline develops for too long, as a result of which unpleasant symptoms have to be endured for a long period of time. I also do not like the need for long-term use of Nitroxoline. It is the listed properties of Nitroxoline that some people do not like, and they leave a negative review of the drug. Positive feedback on the use of Nitroxoline for cystitis is about 85 - 90%, which indicates the high efficacy of the drug. Women who have left positive reviews about Nitroxoline for cystitis, note that the drug allows you to very quickly relieve painful symptoms that go away literally after 1 - 2 receptions. In addition, many women suffering from chronic cystitis, having tried Nitroxoline, realized that they had found the very ideal drug for themselves, which quickly eliminates all symptoms and allows you to feel normal. People consider the need to take the drug 2 tablets 4 times a day for 2 - 3 weeks as a certain inconvenience, but this feature can be considered a lack of a good remedy. Women are ready to put up with this disadvantage, since there is nothing better, more effective and inexpensive at their disposal. Negative reviews about Nitroxoline for cystitis are about 10-15%. Usually negative reviews were left by women for whom Nitroxoline did not help cure cystitis or the symptoms did not go away instantly, after taking literally one dose of the drug. As a result, after taking 2 tablets of Nitroxoline, the women did not receive the immediate effect they had hoped for, the painful symptoms partially remained, which caused emotional disappointment in the drug, on the basis of which they left a negative review. It is noteworthy that among all the negative reviews about Nitroxoline, there is not a single one in which a woman would indicate that she had drunk the drug for a full two-week course, and it turned out to be ineffective. All negative reviews indicate that there is no effect after 1 - 2 days of using the drug, on the basis of which the woman made the decision to change the drug. It can be assumed that the negative reviews about Nitroxoline are due to the mismatch of expectations and the real effect of the drug. The cost of Nitroxoline is low, which is explained by local production, as well as relatively cheap, domestic components of the drug. The difference in cost is usually insignificant and in most cases depends on the pricing policy of a particular pharmacy chain. In Russia, in various pharmacies, a package of Nitroxoline in 50 tablets costs from 43 to 67 rubles, and in Ukraine - from 6.95 to 10.55 hryvnia. In Russia, Nitroxoline in packs of 10 tablets is not sold, and in Ukraine, such a package costs from 1.88 to 2.45 hryvnia. You can buy Nitroxoline at any regular pharmacy or through an online store. When buying, you need to pay attention to the shelf life of the drug, which is 4 years from the date of production. Immediately before use, the tablets must be carefully examined, and if they change color, crumble, break or have streaks on the surface, they should be considered damaged and, accordingly, unusable. The drug should be stored in a dry and dark place at an air temperature not exceeding 15 - 25oС. Violation of storage conditions leads to the loss of the drug's properties, and therefore, its therapeutic efficacy decreases. The preparation contains an active ingredient - nitroxoline. Additional ingredients: sucrose, povidone, aerosil, basic water magnesium carbonate, talc, pigment titanium dioxide, paraffin, beeswax, yellow-orange dye. The main form of release of the drug is coated tablets, packaged in 10 pieces. in cell packs, 5 in a pack. Nitroxoline tablets have antibacterial action. This drug is antibacterial agent derived from 8-hydroxyquinoline. Its action is due to the selective inhibition of bacterial DNA production. The activity of Nitroxoline is manifested against known gram-positive bacteria and gram-negative bacteria, some types of fungi. As a result of oral administration, Nitroxoline-UBF is absorbed from the gastrointestinal tract to a fairly high degree. Excretion occurs with the help of the kidneys, almost unchanged. At the same time, high concentrations of the main substance are mainly determined in the composition of urine. The main indications for the use of Nitroxoline:
In most cases, the development of side effects occurs when patients take the drug without even knowing what these pills are helping from. In this case, there may be deviations in the activity of the digestive system, for example, nausea, vomiting, loss appetite, and sometimes abnormalities in the liver. Possible manifestation allergic reactions- skin rash and itching. Somewhat less often, disturbances in the activity of the nervous system occur, manifesting ataxia, headache, paresthesia, polyneuropathy... Long-term use can cause optic neuritis. In general, as you know, Nitroxoline is antibiotic, therefore, undesirable effects affecting the work of various organs and systems, including the cardiovascular system, are not excluded. According to the instructions for the use of Nitroxoline-UBF, the tablets are taken orally, preferably after a meal. The dosage of the drug is set by the attending physician. On average, adult patients are prescribed 0.1 g per day to 4 times a day. In this case, the duration of treatment can be 2-3 weeks. If necessary, repeated courses are carried out after 2 weeks. The appointment of tablets is also carried out to prevent postoperative infections in the kidney or urinary tract, and it is recommended to take 0.1 g of the drug 4 times a day for 2-3 weeks. Cases of drug overdose may be accompanied by symptoms such as vomiting, nausea, or general weakness. Treatment includes gastric lavage, taking enterosorbents and conducting symptomatic therapy. Taking Nitroxoline together with drugs from the tetracyclines group can enhance the effect of each drug. Simultaneous use Nystatin and Levorina is able to potentiate their action. The combination with nitrofurans causes a negative neurotropic effect, so it is better not to take them together. On prescription. The tablets are stored in a dry, dark place, protected from children. The main analogues are represented by drugs: 5-Nitrox, 5-NOK, Nibiol, Nikinol, Nikopet, Niuron, Noxibiol, Noxin, Urythrol. As the reviews of Nitroxoline show, many patients use this drug for cystitis. It should be noted that women are well aware of this remedy. However, some of them are interested in Nitroxoline tablets - what they are from and how to take the medicine correctly. In most cases, reviews of Nitroxoline with cystitis confirm the rather high effectiveness of these tablets. But there are also reports when the medicine did not help to quickly eliminate the unpleasant symptoms of the disease. Especially often there are discussions about how to take Nitroxoline during pregnancy, although it is contraindicated to use it during this period. Nevertheless, sometimes women are interested in whether it is possible to take these pills during pregnancy, and what are the consequences? At the same time, experts do not recommend self-medication, and if symptoms of the disease appear, immediately consult a doctor. Sometimes this medicine is prescribed to children, but most parents, after careful study of the annotation, doubt whether it is possible for patients to take pills at an early age. They also find out if Nitroxoline is an antibiotic or not, and at what age is it prescribed for cystitis? Experts recommend taking tests before taking these pills and finding out how sensitive the pathogen's microorganisms are to the effects of this antibiotic. Thanks to this, you can understand how effective this treatment will be. Until patients receive test results, antibiotics are not recommended. But you can use local antimicrobial agents, not forgetting about drinking plenty of water, for example, herbal decoctions. In addition, you should discuss with your doctor about possible replacement options, and if this drug is not suitable for treatment, find out how you can quickly find an effective treatment. Only with this approach can one hope that health will be restored fully and in a short time. The price of Nitroxoline in tablets is about 60 rubles. Nitroxoline-UBF tablets 0.05 g 50 pcs Uralbiopharm OJSC Nitroxoline 50mg No. 50 tablets Nitroxoline 50mg No. 50 tab Nitroxoline 50mg No. 50 tabl Anzhero-Sudzhensky KhFZ LLC Nitroxoline 50mg No. 50 tabl Biosynthesis JSC NitroxolineAnzhero-Sudzhensky KhFZ LLC, Russia Nitroxoline Kiev Vitamin Plant (Ukraine, Kiev) NitroxolineVitamins (Ukraine, Uman) Nitroxoline table. 0.05g No. 50Borschagovskiy KhFZ Nitroxoline table. 0.05g No. 50Borschagovskiy KhFZ Nitroxoline table. 0.05g No. 50Borschagovskiy KhFZ Nitroxoline table. 0.05g No. 50Borschagovskiy KhFZ Nitroxoline 50 mg No. 50 tab.p. Nitroxoline 50 mg No. 10 tab.p. To solve problems associated with inflammation in the urinary tract, doctors often prescribe nitroxoline tablets. It is a well-known drug in the pharmaceutical market and is produced by a large number of companies. How and when to take it correctly? If you have been prescribed nitroxoline, is it an antibiotic or not - the first question that you will probably have. The fact is that pharmaceutical companies that manufacture the drug often add the abbreviation of their production to the name to give the drug “credibility”. However, no matter what words are used, nitroxoline remains a drug with a fixed content:
Nitroxoline is not an antibiotic, although, like them, it has antimicrobial effects. The difference lies in the degree of influence on microorganisms: in antibiotics it is more radical, therefore, microbes necessary for the human body also fall under its influence. If you have been prescribed nitroxoline, you need to know what these tablets are from. This drug is indicated for patients:
The antimicrobial effect of nitroxoline is to block the DNA of pathogenic microorganisms, in connection with which the infected cells die and the further spread of the infection is blocked. A set of certain enzymes in the structure of the drug allows you to selectively approach the destruction of pathogenic cells without negatively affecting other tissues and systems of the human body. Here are the microorganisms that are "susceptible" to nitroxoline:
Due to the wide range of effects of the drug, nitroxoline is prescribed for any disease caused by a pathogen from this list. Nitroxoline is often prescribed for cystitis. It is imperative to take into account the severity of the form of the disease, because it determines the dosage of the drug and the effectiveness of treatment. If cystitis passes in an acute form and the symptoms appear for the first time, then it is enough to take a course of two weeks, while it is recommended to take two tablets every six hours. Treatment is considered complete if the patient's urinalysis is free of pathogenic microorganisms three times in a row. For the treatment of chronic cystitis, nitroxoline is taken according to the same scheme. But, if symptoms persist, the dose is increased up to six tablets in a single dose every 12 hours. Such treatment lasts three weeks, and then you need to pass a detailed urine test. If the infection is still there, antibiotics are given. Antibiotic nitroxoline or not - in any case, this is a drug that is considered an effective means of getting rid of ailments of the urinary and reproductive systems. As a rule, the problem is successfully solved in one stage of admission. However, a number of patients complain about a rather long course of therapy. In addition, changes in the color of the urine are sometimes noted. The attending physician should tell the patient in detail about the possible side effects, how to take nitroxoline, in each specific case. Few facts about the product: Instructions for useOnline pharmacy price website: from 82 Release form, composition and packagingThe drug is available in the form of tablets, the working substance is nitroxoline. The auxiliary composition is povidone, milk sugar, titanium dioxide, silica, stearic acid, starch, refined wax. The medicine is packaged in 10 tablets in a blister, five plates in a cardboard box. The standard price of the antibiotic Nitroxoline (50 pcs.) - 53-85 rubles. pharmachologic effectThe active ingredient has an antiprotozoal, antimicrobial effect, inhibits the biosynthesis of DNA nucleic acids, causing the death of bacteria and fungi. The substance is absorbed in the digestive tract and excreted by the kidneys, most of it in the urine. The antimicrobial drug Nitroxoline is available from the prescription department of pharmacies and healthcare providers. IndicationsThe medicine is indicated for the following pathologies:
ContraindicationsReception is contraindicated in serious liver and kidney diseases, hereditary G-6-PD deficiency, hypersensitivity, gestation and breastfeeding, with reduced sensitivity of peripheral nerves and cataracts. Nitroxoline has analogues in composition and indications - Uroxolin, Nitro, 5-Nok, Nitroxolin Forte. Method of administration and dosageFollowing the instructions, the tablets are taken after meals, the standard dosage is 0.1 g four times a day, the course is no more than 20 days. Possible dose adjustment and repetition of treatment, in accordance with the patient's condition. It is possible to order Nitroxoline on the Internet, first, by searching for funds in pharmacies, and by comparing prices. Side effectsIn some cases, the use of an antibiotic causes liver dysfunction, nausea and vomiting, rapid heart rate, headaches and skin rashes. With prolonged use, the development of neuritis of the optic nerves is likely. special instructionsPatients with diabetes are prescribed pills with caution because of the lactose content. There is no information about psychomotor dysfunctions. Before taking the patient, the patient must inform the doctor about all medications taken in order to exclude the incorrect effect of Nitroxoline. Terms and conditions of storageThe shelf life of the tablets is 4 years, storage provides for a dry place, protected from light. User reviews of Nitroxoline emphasize the special effectiveness of the drug in the treatment of cystitis, but the treatment does not help everyone, or you have to resume the course after a while. |
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